Catherine Aiken, MD, PhD

Clinical Assistant Professor

20042019
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Research Output 2004 2019

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Article
2019
3 Citations (Scopus)

A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats

Tarry-Adkins, J. L., Aiken, C. E., Ashmore, T. J., Fernandez-Twinn, D. S., Chen, J. H. & Ozanne, S. E., Jan 2019, In : FASEB Journal. 33, 1, p. 239-253 15 p.

Research output: Contribution to journalArticle

Open Access
Thymus
Nutrition
Thymus Gland
Rats
Telomere
1 Citation (Scopus)

Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats

Aiken, C. E., Tarry-Adkins, J. L., Spiroski, A. M., Nuzzo, A. M., Ashmore, T. J., Rolfo, A., Sutherland, M. J., Camm, E. J., Giussani, D. A. & Ozanne, S. E., May 1 2019, In : Journal of Physiology. 597, 9, p. 2391-2401 11 p.

Research output: Contribution to journalArticle

Open Access
Fetal Hypoxia
Oviducts
Telomere
Mitochondrial DNA
Social Responsibility

Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats

Aiken, C., Tarry-Adkins, J. L., Spiroski, A. M., Nuzzo, A. M., Ashmore, T. J., Rolfo, A., Sutherland, M. J., Camm, E. J., Giussani, D. A. & Ozanne, S. E., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7758-7766 9 p.

Research output: Contribution to journalArticle

Rats
Aging of materials
Fetal Hypoxia
DNA-Activated Protein Kinase
Oxidative stress

Early life environment influences the trajectory of post-partum weight loss in adult female rats

Aiken, C., Tarry-Adkins, J. L., Ashmore, T. J. & Ozanne, S. E., May 1 2019, In : Reproductive biomedicine online. 38, 5, p. 779-786 8 p.

Research output: Contribution to journalArticle

Open Access
Weight Loss
Pregnancy
Lactation
Intra-Abdominal Fat
Control Groups
2 Citations (Scopus)

Improving outcomes in gestational diabetes: does gestational weight gain matter?

Aiken, C. E. M., Hone, L., Murphy, H. R. & Meek, C. L., Feb 1 2019, In : Diabetic Medicine. 36, 2, p. 167-176 10 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Weight Gain
Confidence Intervals
Pregnancy Outcome
Odds Ratio
2018
6 Citations (Scopus)

Contributions of function-Altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty

Howard, S. R., Guasti, L., Poliandri, A., David, A., Cabrera, C. P., Barnes, M. R., Wehkalampi, K., O'Rahilly, S., Aiken, C., Coll, A. P., Ma, M., Rimmington, D., Yeo, G. S. H. & Dunkel, L., Feb 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 2, p. 649-659 11 p.

Research output: Contribution to journalArticle

Delayed Puberty
Genes
Puberty
Exome
Menarche
5 Citations (Scopus)

Insulin-signalling dysregulation and inflammation is programmed trans-generationally in a female rat model of poor maternal nutrition

Tarry-Adkins, J. L., Aiken, C. E., Ashmore, T. J. & Ozanne, S. E., Dec 1 2018, In : Scientific reports. 8, 1, 4014.

Research output: Contribution to journalArticle

Mothers
Insulin
Inflammation
Insulin Receptor Substrate Proteins
Protein-Restricted Diet
20 Citations (Scopus)

Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet

Loche, E., Blackmore, H. L., Carpenter, A. A., Beeson, J. H., Pinnock, A., Ashmore, T. J., Aiken, C., De Almeida-Faria, J., Schoonejans, J. M., Giussani, D. A., Fernandez-Twinn, D. S. & Ozanne, S. E., Aug 1 2018, In : Cardiovascular Research. 114, 10, p. 1372-1384 13 p.

Research output: Contribution to journalArticle

Weaning
Obesity
Mothers
Diet
Maternal Exposure
4 Citations (Scopus)

Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring

Beeson, J. H., Blackmore, H. L., Carr, S. K., Dearden, L., Duque-Guimarães, D. E., Kusinski, L. C., Pantaleão, L. C., Pinnock, A. G., Aiken, C. E., Giussani, D. A., Fernandez-Twinn, D. S. & Ozanne, S. E., Oct 2018, In : Molecular Metabolism. 16, p. 35-44 10 p.

Research output: Contribution to journalArticle

Adult Children
Mothers
Exercise
Pregnancy
Health
2017
2 Citations (Scopus)

Breaking the cycle of intergenerational obesity

Aiken, C. & Ozanne, S. E., Mar 1 2017, In : Journal of Physiology. 595, 5, p. 1443-1444 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
Consultants
Contraception
Pregnancy
Contraceptive Agents
Population
2016
37 Citations (Scopus)

Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth

Tarry-Adkins, J. L., Fernandez-Twinn, D. S., Hargreaves, I. P., Neergheen, V., Aiken, C., Martin-Gronert, M. S., McConnell, J. M. & Ozanne, S. E., Feb 1 2016, In : American Journal of Clinical Nutrition. 103, 2, p. 579-588 10 p.

Research output: Contribution to journalArticle

coenzyme Q10
Hyperinsulinism
Oxidative Stress
Fibrosis
Mothers
20 Citations (Scopus)

Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet

Aiken, C. E., Tarry-Adkins, J. L., Penfold, N. C., Dearden, L. & Ozanne, S. E., Apr 2016, In : FASEB Journal. 30, 4, p. 1548-1556 9 p.

Research output: Contribution to journalArticle

Organelle Biogenesis
Nutrition
Lipid Peroxidation
Mothers
Diet
16 Citations (Scopus)

Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats

Tarry-Adkins, J. L., Fernandez-Twinn, D. S., Chen, J. H., Hargreaves, I. P., Neergheen, V., Aiken, C. E. & Ozanne, S. E., Oct 1 2016, In : DMM Disease Models and Mechanisms. 9, 10, p. 1221-1229 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Nutrition
Muscle
Rats
Skeletal Muscle
4 Citations (Scopus)

The influence of hours worked prior to delivery on maternal and neonatal outcomes: a retrospective cohort study

Aiken, C. E., Aiken, A. R., Scott, J. G. & Brockelsby, J. C., Nov 1 2016, In : American journal of obstetrics and gynecology. 215, 5, p. 634.e1-634.e7

Research output: Contribution to journalArticle

Cohort Studies
Retrospective Studies
Mothers
Fatigue
Obstetric Delivery
6 Citations (Scopus)

Weekend working: A retrospective cohort study of maternal and neonatal outcomes in a large NHS delivery unit

Aiken, C. E., Aiken, A. R., Scott, J. G., Brockelsby, J. C. & Trussell, J., Apr 1 2016, In : European Journal of Obstetrics and Gynecology and Reproductive Biology. 199, p. 5-10 6 p.

Research output: Contribution to journalArticle

Consultants
Cohort Studies
Retrospective Studies
Mothers
Contracts
2015
5 Citations (Scopus)

Factors associated with adverse clinical outcomes among obstetrics trainees

Aiken, C. E., Aiken, A. R., Park, H., Brockelsby, J. C. & Prentice, A., Jul 1 2015, In : Medical Education. 49, 7, p. 674-683 10 p.

Research output: Contribution to journalArticle

obstetrics
trainee
supervision
recording
confidence
9 Citations (Scopus)

Influence of the duration of the second stage of labor on the likelihood of obstetric anal sphincter injury

Aiken, C., Aiken, A. R. & Prentice, A., Mar 1 2015, In : Birth. 42, 1, p. 86-93 8 p.

Research output: Contribution to journalArticle

Second Labor Stage
Anal Canal
Obstetrics
Wounds and Injuries
Birthing Centers
11 Citations (Scopus)

Management of fetal malposition in the second stage of labor: A propensity score analysis

Aiken, A. R., Aiken, C. E., Alberry, M. S., Brockelsby, J. C. & Scott, J. G., Mar 1 2015, In : American journal of obstetrics and gynecology. 212, 3, p. 355.e1-355.e7

Research output: Contribution to journalArticle

Second Labor Stage
Propensity Score
Odds Ratio
Selection Bias
Mothers
4 Citations (Scopus)

Maternal and fetal outcomes following unplanned conversion to general anesthetic at elective cesarean section

Aiken, C., Aiken, A. R., Cole, J. C., Brockelsby, J. C. & Bamber, J. H., Sep 28 2015, In : Journal of Perinatology. 35, 9, p. 695-699 5 p.

Research output: Contribution to journalArticle

General Anesthetics
Cesarean Section
Odds Ratio
Mothers
Maternal Age

Oxidative stress: Its role in regulating aging and longevity

Aiken, C., Tarry-Adkins, J. L. & Ozanne, S. E., Jan 1 2015, In : Biochemist. 37, 4, p. 16-19 4 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Aging of materials
Cell Aging
Pathologic Processes
25 Citations (Scopus)

Transgenerational developmental programming of ovarian reserve

Aiken, C. E., Tarry-Adkins, J. L. & Ozanne, S. E., Nov 3 2015, In : Scientific reports. 5, 16175.

Research output: Contribution to journalArticle

Diet
Reproductive Behavior
Protein-Restricted Diet
Intra-Abdominal Fat
Telomere
2014
15 Citations (Scopus)

Antenatal glucocorticoids prior to cesarean delivery at term

Aiken, C., Fowden, A. L. & Smith, G. C. S., Jan 1 2014, In : JAMA Pediatrics. 168, 6, p. 507-508 2 p.

Research output: Contribution to journalArticle

Fetal Organ Maturity
Term Birth
Betamethasone
Cesarean Section
Glucocorticoids
19 Citations (Scopus)

Factors influencing the likelihood of instrumental delivery success

Aiken, C. E., Aiken, A. R., Brockelsby, J. C. & Scott, J. G., Apr 1 2014, In : Obstetrics and gynecology. 123, 4, p. 796-803 8 p.

Research output: Contribution to journalArticle

Odds Ratio
Birth Weight
Second Labor Stage
Epidural Analgesia
Maternal Age
143 Citations (Scopus)

Transgenerational developmental programming

Aiken, C. E. & Ozanne, S. E., Jan 1 2014, In : Human Reproduction Update. 20, 1, p. 63-75 13 p., dmt043.

Research output: Contribution to journalArticle

Mothers
Epigenomics
Phenotype
Zygote
Maternal Age
2013
57 Citations (Scopus)

Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart

Tarry-Adkins, J. L., Martin-Gronert, M. S., Fernandez-Twinn, D. S., Hargreaves, I., Alfaradhi, M. Z., Land, J. M., Aiken, C. & Ozanne, S. E., Jan 1 2013, In : FASEB Journal. 27, 1, p. 379-390 12 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Nutrition
DNA Repair
DNA Glycosylases
DNA Damage
26 Citations (Scopus)

Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract

Aiken, C., Tarry-Adkins, J. L. & Ozanne, S. E., Oct 1 2013, In : FASEB Journal. 27, 10, p. 3959-3965 7 p.

Research output: Contribution to journalArticle

Oviducts
Nutrition
DNA Damage
Animals
Aging of materials
2012
2 Citations (Scopus)

Long-term effects of in utero Doppler ultrasound scanning - A developmental programming perspective

Aiken, C. & Lees, C. C., Apr 1 2012, In : Medical Hypotheses. 78, 4, p. 539-541 3 p.

Research output: Contribution to journalArticle

Doppler Ultrasonography
Fetus
Free Radicals
Pregnancy
Functional Laterality
2008
38 Citations (Scopus)

Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress

Aiken, C., Cindrova-Davies, T. & Johnson, M. H., Jan 1 2008, In : Reproductive biomedicine online. 17, 6, p. 806-813 8 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Fertilization
Oxidative Stress
Parturition
Embryonic Structures
2004
36 Citations (Scopus)

The direct measurement of embryogenic volume and nucleo-cytoplasmic ratio during mouse pre-implantation development

Aiken, C., Swoboda, P. P. L., Skepper, J. N. & Johnson, M. H., Nov 1 2004, In : Reproduction. 128, 5, p. 527-535 9 p.

Research output: Contribution to journalArticle

Trophoblasts
Germ Layers
Blastomeres
Interphase
Blastocyst