Donald Elbert, PhD

Associate Professor

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Personal profile


Professor Elbert received his PhD from the University of Texas at Austin in Chemical Engineering. He performed research at Caltech and ETH-Zurich before joining the faculty of the Department of Biomedical Engineering at Washington University in 2000. He has made pivotal contributions in the production of hydrogels for use as cell scaffolds. He introduced hydrogel crosslinking chemistries that have been adopted by many researchers in the field. Professor Elbert also introduced a bottom-up method to assemble enzymatically degradable microparticles into scaffolds in the presence of cells. The advantage of this method is that cells first degrade between microparticles and create their own pathways for migration. To make the method more practical, he introduced and patented a new method to produce cell-sized hydrogel microspheres. The materials have proven useful to promote peripheral nerve regeneration in vivo. Professor Elbert also has an interest in the self-assembly process that leads to the formation of senile plaques in Alzheimer's disease. He helped to develop a mathematical model that led to the discovery that the turnover of plaque-forming peptides slows tremendously with aging.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Polyethylene glycols Chemical Compounds
Ethylene Glycol Medicine & Life Sciences
Microspheres Chemical Compounds
Sphingosines Engineering & Materials Science
Amyloid Medicine & Life Sciences
Scaffolds Chemical Compounds
Hydrogels Chemical Compounds
Proteins Engineering & Materials Science

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Research Output 1994 2018

Amyloid-β Plaques in clinical Alzheimer's disease brain incorporate stable isotope tracer in vivo and exhibit nanoscale heterogeneity

Wildburger, N. C., Gyngard, F., Guillermier, C., Patterson, B. W., Elbert, D., Mawuenyega, K. G., Schneider, T., Green, K., Roth, R., Schmidt, R. E., Cairns, N. J., Benzinger, T. L. S., Steinhauser, M. L. & Bateman, R. J., Mar 22 2018, In : Frontiers in Neurology. 9, MAR, 169.

Research output: Contribution to journalArticle

Amyloid Plaques
Alzheimer Disease
Isotope Labeling
12 Citations

Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics

Lucey, B. P., Hicks, T. J., McLeland, J. S., Toedebusch, C. D., Boyd, J., Elbert, D., Patterson, B. W., Baty, J., Morris, J. C., Ovod, V., Mawuenyega, K. G. & Bateman, R. J., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 197-204 8 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Alzheimer Disease
Sodium Oxybate

Reply to “Excess amyloid beta can be degraded in healthy humans”

Lucey, B. P., Hicks, T. J., Elbert, D., Ovod, V., Mawuenyega, K. G., Morris, J. C. & Bateman, R. J., Mar 1 2018, In : Annals of Neurology. 83, 3, p. 650-651 2 p.

Research output: Contribution to journalLetter

14 Citations

Associations between β-amyloid kinetics and the β-amyloid diurnal pattern in the central nervous system

Lucey, B. P., Mawuenyega, K. G., Patterson, B. W., Elbert, D., Ovod, V., Kasten, T., Morris, J. C. & Bateman, R. J., Feb 1 2017, In : JAMA Neurology. 74, 2, p. 207-215 9 p.

Research output: Contribution to journalArticle

Central Nervous System
Cerebrospinal Fluid
44 Citations

Age and amyloid effects on human central nervous system amyloid-beta kinetics

Patterson, B. W., Elbert, D., Mawuenyega, K. G., Kasten, T., Ovod, V., Ma, S., Xiong, C., Chott, R., Yarasheski, K., Sigurdson, W., Zhang, L., Goate, A., Benzinger, T., Morris, J. C., Holtzman, D. & Bateman, R. J., Sep 1 2015, In : Annals of Neurology. 78, 3, p. 439-453 15 p.

Research output: Contribution to journalArticle

Central Nervous System
Alzheimer Disease