Hitoshi Morikawa, MD, PhD

Associate Professor

19942019
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Research Output 1994 2019

2019
5 Citations (Scopus)

A corticotropin releasing factor network in the extended amygdala for anxiety

Pomrenze, M. B., Tovar-Diaz, J., Blasio, A., Maiya, R., Giovanetti, S. M., Lei, K., Morikawa, H., Woodward Hopf, F. & Messing, R. O., Feb 2019, In : Journal of Neuroscience. 39, 6, p. 1030-1043 14 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone
Amygdala
Septal Nuclei
Anxiety
Neurons
2018
6 Citations (Scopus)

Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning

Tovar-Díaz, J., Pomrenze, M. B., Kan, R., Pahlavan, B. & Morikawa, H., Mar 6 2018, In : Cell Reports. 22, 10, p. 2756-2766 11 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Corticotropin-Releasing Hormone
N-Methylaspartate
Cocaine
Adrenergic Agents
16 Citations (Scopus)

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

Gantz, S. C., Ford, C. P., Morikawa, H. & Williams, J. T., Feb 10 2018, In : Annual Review of Physiology. 80, p. 219-241 23 p.

Research output: Contribution to journalReview article

Ventral Tegmental Area
Dopaminergic Neurons
Substantia Nigra
Population
Neurochemistry
2017
6 Citations (Scopus)

Junk food diet-induced obesity increases D2 receptor autoinhibition in the ventral tegmental area and reduces ethanol drinking

Cook, J. B., Hendrickson, L. M., Garwood, G. M., Toungate, K. M., Nania, C. V. & Morikawa, H., Aug 2017, In : PloS one. 12, 8, e0183685.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Nutrition
drinking
Drinking
obesity
11 Citations (Scopus)

Mechanistic insights into epigenetic modulation of ethanol consumption

Ponomarev, I., Stelly, C. E., Morikawa, H., Blednov, Y. A., Mayfield, R. D. & Harris, R. A., May 1 2017, In : Alcohol. 60, p. 95-101 7 p.

Research output: Contribution to journalArticle

decitabine
Epigenomics
Ethanol
Modulation
Ventral Tegmental Area
2016
7 Citations (Scopus)

Differential Dopamine Regulation of Ca2+ Signaling and Its Timing Dependence in the Nucleus Accumbens

Swapna, I., Bondy, B. & Morikawa, H., Apr 19 2016, In : Cell Reports. 15, 3, p. 563-573 11 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Dopamine
Neurons
Metabotropic Glutamate Receptors
Neuronal Plasticity
17 Citations (Scopus)

L-type Ca 2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory

Degoulet, M., Stelly, C. E., Ahn, K. C. & Morikawa, H., Mar 1 2016, In : Molecular psychiatry. 21, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Neuronal Plasticity
Antihypertensive Agents
Cues
Isradipine
19 Citations (Scopus)

Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning

Stelly, C. E., Pomrenze, M. B., Cook, J. B. & Morikawa, H., Jul 4 2016, In : eLife. 5, 2016JULY, e15448.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Neuronal Plasticity
Long-Term Potentiation
Cocaine
Cues
2014

Neural Plasticity in the Ventral Tegmental Area and Alcohol Addiction

Whitaker, L. R., Hendrickson, L. M. & Morikawa, H., Jan 1 2014, Neurobiology of Alcohol Dependence. Elsevier Inc., p. 227-249 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ventral Tegmental Area
Neuronal Plasticity
Alcoholism
Ethanol
Dopaminergic Neurons
2013
13 Citations (Scopus)

Inositol 1,4,5-triphosphate drives glutamatergic and cholinergic inhibition selectively in spiny projection neurons in the striatum

Clements, M. A., Swapna, I. & Morikawa, H., Feb 6 2013, In : Journal of Neuroscience. 33, 6, p. 2697-2708 12 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Cholinergic Agents
Corpus Striatum
Ryanodine Receptor Calcium Release Channel
Neurons
51 Citations (Scopus)

New insights on neurobiological mechanisms underlying alcohol addiction

Cui, C., Noronha, A., Morikawa, H., Alvarez, V. A., Stuber, G. D., Szumlinski, K. K., Kash, T. L., Roberto, M. & Wilcox, M. V., Apr 1 2013, In : Neuropharmacology. 67, p. 223-232 10 p.

Research output: Contribution to journalReview article

Alcoholism
Binge Drinking
Drinking Behavior
Neuropeptides
Reward
72 Citations (Scopus)

Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning

Whitaker, L. R., Degoulet, M. & Morikawa, H., Jan 23 2013, In : Neuron. 77, 2, p. 335-345 11 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Neuronal Plasticity
Learning
Social Isolation
Amphetamine
2012
45 Citations (Scopus)

Complex autonomous firing patterns of striatal low-threshold spike interneurons

Beatty, J. A., Sullivan, M. A., Morikawa, H. & Wilson, C. J., Aug 1 2012, In : Journal of neurophysiology. 108, 3, p. 771-781 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Interneurons
Neurons
Cholinergic Agents
Calcium
2011
140 Citations (Scopus)

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

Blednov, Y. A., Benavidez, J. M., Geil, C., Perra, S., Morikawa, H. & Harris, R. A., Jun 1 2011, In : Brain, Behavior, and Immunity. 25, SUPPL. 1, p. S92-S105

Research output: Contribution to journalArticle

Lipopolysaccharides
Alcohol Drinking
Alcohols
Ethanol
Ventral Tegmental Area
81 Citations (Scopus)

Dynamic regulation of midbrain dopamine neuron activity: Intrinsic, synaptic, and plasticity mechanisms

Morikawa, H. & Paladini, C. A., Dec 15 2011, In : Neuroscience. 198, p. 95-111 17 p.

Research output: Contribution to journalReview article

Neuronal Plasticity
Dopaminergic Neurons
Mesencephalon
Hope
Basal Ganglia
44 Citations (Scopus)

GABAergic transmission modulates ethanol excitation of ventral tegmental area dopamine neurons

Theile, J. W., Morikawa, H., Gonzales, R. A. & Morrisett, R. A., Jan 13 2011, In : Neuroscience. 172, p. 94-103 10 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Dopaminergic Neurons
Ethanol
Inhibitory Postsynaptic Potentials
Picrotoxin
34 Citations (Scopus)

In vivo ethanol experience increases D 2 autoinhibition in the ventral tegmental area

Perra, S., Clements, M. A., Bernier, B. E. & Morikawa, H., Apr 1 2011, In : Neuropsychopharmacology. 36, 5, p. 993-1002 10 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Ethanol
Dopaminergic Neurons
GABA-B Receptors
Calcium-Calmodulin-Dependent Protein Kinase Type 2
50 Citations (Scopus)

Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area

Bernier, B. E., Whitaker, L. R. & Morikawa, H., Apr 6 2011, In : Journal of Neuroscience. 31, 14, p. 5205-5212 8 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
Ethanol
Alcoholism

Small K channels: Big targets for treating alcoholism?

Morikawa, H. & Harris, R. A., Apr 1 2011, In : Biological Psychiatry. 69, 7, p. 614-615 2 p.

Research output: Contribution to journalComment/debate

Small-Conductance Calcium-Activated Potassium Channels
Calcium Channel Agonists
Large-Conductance Calcium-Activated Potassium Channels
Biological Models
Alcoholism
2010
63 Citations (Scopus)

Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area. Interaction with Intrinsic Ion Channels and Neurotransmitter Inputs

Morikawa, H. & Morrisett, R. A., Jan 1 2010, International Review of Neurobiology. C ed. Academic Press Inc., p. 235-288 54 p. (International Review of Neurobiology; vol. 91, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ventral Tegmental Area
Dopaminergic Neurons
Ion Channels
Neurotransmitter Agents
Ethanol
37 Citations (Scopus)

IP3 receptor sensitization during in vivo amphetamine experience enhances NMDA receptor plasticity in dopamine neurons of the ventral tegmental area

Ahn, K. C., Bernier, B. E., Harnett, M. T. & Morikawa, H., May 12 2010, In : Journal of Neuroscience. 30, 19, p. 6689-6699 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Ventral Tegmental Area
Dopaminergic Neurons
Amphetamine
N-Methyl-D-Aspartate Receptors
2009
70 Citations (Scopus)

Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons

Harnett, M. T., Bernier, B. E., Ahn, K. C. & Morikawa, H., Jun 25 2009, In : Neuron. 62, 6, p. 826-838 13 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Glutamate Receptors
Mesencephalon
N-Methyl-D-Aspartate Receptors
Reward
40 Citations (Scopus)

Role of 5-hydroxytryptamine 2C receptors in Ca 2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons

Theile, J. W., Morikawa, H., Gonzales, R. A. & Morrisett, R. A., May 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 2, p. 625-633 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Serotonin Receptors
Dopaminergic Neurons
gamma-Aminobutyric Acid
Ethanol
2008
70 Citations (Scopus)

Ethanol enhances GABAergic transmission onto dopamine neurons in the ventral tegmental area of the rat

Theile, J. W., Morikawa, H., Gonzales, R. A. & Morrisett, R. A., Jun 1 2008, In : Alcoholism: Clinical and Experimental Research. 32, 6, p. 1040-1048 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Dopaminergic Neurons
Neurons
Rats
Dopamine
86 Citations (Scopus)

Recurrent inhibitory network among striatal cholinergic interneurons

Sullivan, M. A., Chen, H. & Morikawa, H., Aug 27 2008, In : Journal of Neuroscience. 28, 35, p. 8682-8690 9 p.

Research output: Contribution to journalArticle

Corpus Striatum
Interneurons
Cholinergic Agents
Cholinergic Fibers
Nicotinic Receptors
2007
45 Citations (Scopus)

Differential regulation of action potential- and metabotropic glutamate receptor-induced Ca2+ signals by inositol 1,4,5-trisphosphate in dopaminergic neurons

Cui, G., Bernier, B. E., Harnett, M. T. & Morikawa, H., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4776-4785 10 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Inositol 1,4,5-Trisphosphate
Dopaminergic Neurons
Action Potentials
Inositol 1,4,5-Trisphosphate Receptors
2006

Erratum: Transcriptional signatures of cellular plasticity in mice lacking the α1 subunit of GABAA receptors (Journal of Neuroscience (May 24, 2006) (5673-5683))

Ponomarev, I., Maiya, R., Harnett, M. T., Schafer, G. L., Ryabinin, A. E., Blednov, Y. A., Morikawa, H., Boehm, S. L., Homanics, G. E., Berman, A., Lodowski, K. H., Bergeson, S. E. & Harris, R. A., Sep 8 2006, In : Journal of Neuroscience. 26, 24

Research output: Contribution to journalComment/debate

GABA-A Receptors
Neurosciences
Cell Plasticity
129 Citations (Scopus)

Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice

Okamoto, T., Harnett, M. T. & Morikawa, H., Feb 1 2006, In : Journal of neurophysiology. 95, 2, p. 619-626 8 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Mesencephalon
Cations
Ethanol
Alcohol Drinking
47 Citations (Scopus)

Transcriptional signatures of cellular plasticity in mice lacking the α1 subunit of GABAA receptors

Ponomarev, I., Maiya, R., Harnett, M. T., Schafer, G. L., Ryabinin, A. E., Blednov, Y. A., Morikawa, H., Boehm, S. L., Homanics, G. E., Berman, A., Lodowski, K. H., Bergeson, S. E. & Adron Harris, R., Sep 7 2006, In : Journal of Neuroscience. 26, 21, p. 5673-5683 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Neuronal Plasticity
Synaptic Transmission
Neuroglia
Neurogranin
2004
Neurobiology
Electrophysiology
Neurosciences
Alcoholism
Research
46 Citations (Scopus)

Spontaneous opening of T-Type Ca2+ channels contributes to the irregular firing of dopamine neurons in neonatal rats

Cui, G., Okamoto, T. & Morikawa, H., Dec 8 2004, In : Journal of Neuroscience. 24, 49, p. 11079-11087 9 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Amphetamine
Mibefradil
Ruthenium Red
Ryanodine
2003
47 Citations (Scopus)

Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism

Paladini, C. A., Robinson, S., Morikawa, H., Williams, J. T. & Palmiter, R. D., Mar 4 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 5, p. 2866-2871 6 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Dopamine
Neuronal Plasticity
Electrophysiology
Patch-Clamp Techniques
132 Citations (Scopus)

Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons

Morikawa, H., Khodakhah, K. & Williams, J. T., Jan 1 2003, In : Journal of Neuroscience. 23, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

Cyclic ADP-Ribose
Metabotropic Glutamate Receptors
Dopaminergic Neurons
Ryanodine Receptor Calcium Release Channel
Neurotransmitter Agents
2001
24 Citations (Scopus)

Activation of μ-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade

Shoda, T., Fukuda, K., Uga, H., Mima, H. & Morikawa, H., Jan 1 2001, In : Anesthesiology. 95, 4, p. 983-989 7 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Opioid Receptors
Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
fos Genes
99 Citations (Scopus)

Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons

Paladini, C. A., Fiorillo, C. D., Morikawa, H. & Williams, J. T., Mar 17 2001, In : Nature Neuroscience. 4, 3, p. 275-281 7 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Amphetamine
Glutamic Acid
Dopamine
Metabotropic Glutamate Receptors
2000
67 Citations (Scopus)

Inositol 1,4,5-triphosphate-evoked responses in midbrain dopamine neurons.

Morikawa, H., Imani, F., Khodakhah, K. & Williams, J. T., Oct 15 2000, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 20, 20, p. RC103

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Inositol 1,4,5-Trisphosphate
Dopaminergic Neurons
Mesencephalon
Ruthenium Red
70 Citations (Scopus)

Regulation of central synaptic transmission by 5-HT(1B) auto- and Heteroreceptors

Morikawa, H., Manzoni, O. J., Crabbe, J. C. & Williams, J. T., Jan 1 2000, In : Molecular pharmacology. 58, 6, p. 1271-1278 8 p.

Research output: Contribution to journalShort survey

Receptor, Serotonin, 5-HT1B
Autoreceptors
Synaptic Transmission
Serotonin
Inhibitory Postsynaptic Potentials
1999
8 Citations (Scopus)

Opioid potentiation of N-type Ca2+ channel currents via pertussis- toxin-sensitive G proteins in NG108-15 cells

Morikawa, H., Mima, H., Uga, H., Shoda, T. & Fukuda, K., Aug 11 1999, In : Pflugers Archiv European Journal of Physiology. 438, 3, p. 423-426 4 p.

Research output: Contribution to journalArticle

Enkephalins
Pertussis Toxin
GTP-Binding Proteins
Opioid Analgesics
Conotoxins
1998
17 Citations (Scopus)

Activation of phospholipase A2 by the nociceptin receptor expressed in Chinese hamster ovary cells

Fukuda, K., Shoda, T., Morikawa, H., Kato, S., Mima, H. & Mori, K., Nov 1 1998, In : Journal of Neurochemistry. 71, 5, p. 2186-2192 7 p.

Research output: Contribution to journalArticle

Phospholipase A2 Receptors
Phospholipases A2
Cricetulus
Ovary
Chemical activation
19 Citations (Scopus)

Adaptations to chronic agonist exposure of μ-opioid receptor- expressing Chinese hamster ovary cells

Kato, S., Fukuda, K., Morikawa, H., Shoda, T., Mima, H. & Mori, K., Mar 19 1998, In : European Journal of Pharmacology. 345, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Cricetulus
Ovary
Down-Regulation
Enkephalins
20 Citations (Scopus)

Desensitization and resensitization of δ-opioid receptor-mediated Ca2+ channel inhibition in NG108-15 cells

Morikawa, H., Fukuda, K., Mima, H., Shoda, T., Kato, S. & Mori, K., Mar 30 1998, In : British Journal of Pharmacology. 123, 6, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Phosphoprotein Phosphatases
Protein Kinase C
Okadaic Acid
Hybrid Cells
28 Citations (Scopus)

Nociceptin receptor-mediated Ca2+ channel inhibition and its desensitization in NG108-15 cells

Morikawa, H., Fukuda, K., Mima, H., Shoda, T., Kato, S. & Mori, K., Jun 19 1998, In : European Journal of Pharmacology. 351, 2, p. 247-252 6 p.

Research output: Contribution to journalArticle

Pertussis Toxin
Conotoxins
Neuroblastoma
GTP-Binding Proteins
Glioma
17 Citations (Scopus)

Partial agonistic activity of naloxone on the opioid receptors expressed from complementary deoxyribonucleic acids in Chinese hamster ovary cells

Fukuda, K., Kato, S., Shoda, T., Morikawa, H., Mima, H. & Mori, K., Aug 19 1998, In : Anesthesia and analgesia. 87, 2, p. 450-455 6 p.

Research output: Contribution to journalArticle

Opioid Receptors
Naloxone
Cricetulus
Ovary
DNA
18 Citations (Scopus)

Tyrosine kinase inhibitors suppress N-type and T-type Ca2+ channel currents in NG108-15 cells

Morikawa, H., Fukuda, K., Mima, H., Shoda, T., Kato, S. & Mori, K., Jan 1 1998, In : Pflugers Archiv European Journal of Physiology. 436, 1, p. 127-132 6 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Genistein
Modulation
Protein Kinase Inhibitors
Hybrid Cells
1997
39 Citations (Scopus)

Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells

Fukuda, K., Shoda, T., Morikawa, H., Kato, S. & Mori, K., Jul 28 1997, In : FEBS Letters. 412, 2, p. 290-294 5 p.

Research output: Contribution to journalArticle

Cricetulus
Mitogen-Activated Protein Kinases
Ovary
Chemical activation
Cells
22 Citations (Scopus)

Ca2+ channel inhibition by endomorphins via the cloned μ-opioid receptor expressed in NG108-15 cells

Mima, H., Morikawa, H., Fukuda, K., Kato, S., Shoda, T. & Mori, K., Dec 11 1997, In : European Journal of Pharmacology. 340, 2-3, p. R1-R2

Research output: Contribution to journalShort survey

Opioid Receptors
Peptides
endomorphin 2
endomorphin 1
1996
171 Citations (Scopus)

Functional coupling of the δ-, μ-, and κ-opioid receptors to mitogen- activated protein kinase and arachidonate release in Chinese hamster ovary cells

Fukuda, K., Kato, S., Morikawa, H., Shoda, T. & Mori, K., Sep 1 1996, In : Journal of Neurochemistry. 67, 3, p. 1309-1316 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Cricetulus
Mitogen-Activated Protein Kinases
Ovary
Cells
15 Citations (Scopus)

Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells

Noda, M., Ishizaka, N., Yokoyama, S., Hoshi, N., Kimura, Y., Hashii, M., Taketo, M., Egorova, A., Knijnik, R., Fukuda, K., Morikawa, H., Brown, D. A. & Higashida, H., Jan 1 1996, In : Journal of Lipid Mediators and Cell Signalling. 14, 1-3, p. 175-185 11 p.

Research output: Contribution to journalArticle

Hybrid Cells
Type C Phospholipases
Bradykinin
Muscarinic Receptors
Inositol
1995
28 Citations (Scopus)

Coupling of the Cloned μ‐Opioid Receptor with the ω‐Conotoxin‐Sensitive Ca2+ Current in NG108‐15 Cells

Morikawa, H., Fukuda, K., Kato, S., Mori, K. & Higashida, H., Jan 1 1995, In : Journal of Neurochemistry. 65, 3, p. 1403-1406 4 p.

Research output: Contribution to journalArticle

Enkephalins
Opioid Receptors
Opioid Analgesics
Conotoxins
Pertussis Toxin