John Kuo, MD, PhD

Chair of the Department of Neurosurgery; Surgical Director of the Mulva Clinic; Professor of Neurosurgery

1991 …2019
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Research Output 1991 2019

2019

[124I]CLR1404 PET/CT in High-Grade Primary and Metastatic Brain Tumors

Hall, L. T., Titz, B., Baidya, N., van der Kolk, A. G., Robins, H. I., Otto, M., Perlman, S. B., Weichert, J. P. & Kuo, J., Jan 1 2019, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Brain Neoplasms
Positron-Emission Tomography
Magnetic Resonance Imaging
Neoplasms
CLR1404

An investigation into the challenges of using metal additive manufacturing for the production of patient-specific aneurysm clips

Walker, B. J., Cox, B. L., Cikla, U., De Bellefon, G. M., Rankouhi, B., Steiner, L. J., Mahadumrongkul, P., Petry, G., Thevamaran, M., Swader, R., Kuo, J., Suresh, K., Thoma, D. & Eliceiri, K. W., Sep 1 2019, In : Journal of Medical Devices, Transactions of the ASME. 13, 3, 031009.

Research output: Contribution to journalArticle

3D printers
Surgical Instruments
Aneurysm
Metals
Stainless steel
4 Citations (Scopus)

A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment

Basic Science Committee of the Society of University Surgeons, Jan 1 2019, In : Annals of surgery. 269, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

Delivery of Health Care
Mentors
Translational Medical Research
Investigational Therapies
Expert Testimony

Combined Nivolumab and Ipilimumab Is an Effective Treatment for Melanoma Brain Metastases

Traylor, J. I. & Kuo, J., Mar 1 2019, In : Clinical Neurosurgery. 84, 3, p. E134-E135

Research output: Contribution to journalComment/debate

Open Access
Melanoma
Neoplasm Metastasis
Brain
ipilimumab
nivolumab
23 Citations (Scopus)

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Steroids in the Treatment of Adults with Metastatic Brain Tumors

Ryken, T. C., Kuo, J., Prabhu, R. S., Sherman, J. H., Kalkanis, S. N. & Olson, J. J., Mar 1 2019, In : Clinical Neurosurgery. 84, 3, p. E189-E191

Research output: Contribution to journalReview article

Brain Neoplasms
Steroids
Guidelines
Adrenal Cortex Hormones
Intracranial Pressure
23 Citations (Scopus)

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Surgery in the Management of Adults with Metastatic Brain Tumors

Nahed, B. V., Alvarez-Breckenridge, C., Brastianos, P. K., Shih, H., Sloan, A., Ammirati, M., Kuo, J., Ryken, T. C., Kalkanis, S. N. & Olson, J. J., Mar 1 2019, In : Clinical Neurosurgery. 84, 3, p. E152-E155

Research output: Contribution to journalReview article

Brain Neoplasms
Radiosurgery
Guidelines
Radiotherapy
Brain

Delta-24-RGD adenoviral therapy directs oncolytic and immune-mediated anti-tumor effects in recurrent malignant glioma patients

Traylor, J. I. & Kuo, J., Jan 1 2019, In : Clinical Neurosurgery. 84, 1, p. E11-E12

Research output: Contribution to journalComment/debate

Open Access
Glioma
Neoplasms
Therapeutics

Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix

Umlauf, B. J., Clark, P. A., Lajoie, J. M., Georgieva, J. V., Bremner, S., Herrin, B. R., Kuo, J. & Shusta, E. V., May 15 2019, In : Science Advances. 5, 5, eaau4245.

Research output: Contribution to journalArticle

Open Access
lymphocytes
brain
blood-brain barrier
matrices
mannitol
2018

Extracellular Vesicles Containing PD-L1 Contribute to Immune Evasion in Glioblastoma

Lubin, J. A., Zhang, R. R. & Kuo, J., Sep 1 2018, In : Neurosurgery. 83, 3, p. E98-E100

Research output: Contribution to journalArticle

Open Access
Immune Evasion
Glioblastoma
Extracellular Vesicles
6 Citations (Scopus)

Gallium maltolate disrupts tumor iron metabolism and retards the growth of glioblastoma by inhibiting mitochondrial function and ribonucleotide reductase

Chitambar, C. R., Al-Gizawiy, M. M., Alhajala, H. S., Pechman, K. R., Wereley, J. P., Wujek, R., Clark, P. A., Kuo, J., Antholine, W. E. & Schmainda, K. M., Jun 1 2018, In : Molecular cancer therapeutics. 17, 6, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Glioblastoma
Iron
Gallium
Growth
1 Citation (Scopus)

Minimally-invasive approach to posterior fossa decompression: Initial experience in Adult Chiari Type 1 Malformation patients

Teo, K. A., Yang, L., Leow, R., Lwin, S. & Kuo, J., Oct 1 2018, In : Journal of Clinical Neuroscience. 56, p. 90-94 5 p.

Research output: Contribution to journalArticle

Arnold-Chiari Malformation
Decompression
Minimally Invasive Surgical Procedures
Safety

Potential CAR T Cell Immunotherapy Against Diffuse Midline Gliomas

Lubin, J. A., Clark, P. A. & Kuo, J., Nov 1 2018, In : Clinical Neurosurgery. 83, 5, p. E198-E199

Research output: Contribution to journalShort survey

Glioma
Immunotherapy
T-Lymphocytes

Predicting primary outcomes of brain tumor patients with advanced neuroimaging MRI measures

Vergun, S., Suhonen, J. I., Nair, V. A., Kuo, J., Baskaya, M. K., Garcia-Ramos, C., Meyerand, E. E. & Prabhakaran, V., Sep 1 2018, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 13, p. 109-118 10 p.

Research output: Contribution to journalArticle

Neuroimaging
Brain Neoplasms
Language
Magnetic Resonance Imaging
Demography
3 Citations (Scopus)

Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients

Vysotski, S., Madura, C., Swan, B., Holdsworth, R., Lin, Y., Munoz Del Rio, A., Wood, J., Kundu, B., Penwarden, A., Voss, J., Gallagher, T., Nair, V. A., Field, A., Garcia-Ramos, C., Meyerand, M. E., Baskaya, M., Prabhakaran, V. & Kuo, J., Sep 1 2018, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 13, p. 40-45 6 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Magnetic Resonance Imaging
Morbidity
Mortality
Electric Stimulation
9 Citations (Scopus)

Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

Hsu, S. P. C., Kuo, J., Chiang, H. C., Wang, H. E., Wang, Y. S., Huang, C. C., Huang, Y. C., Chi, M. S., Mehta, M. P. & Chi, K. H., Jan 1 2018, In : Oncotarget. 9, 6, p. 6883-6896 14 p.

Research output: Contribution to journalArticle

temozolomide
Chloroquine
Sirolimus
Glioblastoma
Autophagy
1 Citation (Scopus)

Zika virus has oncolytic activity against glioblastoma stem cells

Lubin, J. A., Zhang, R. R. & Kuo, J., Jan 1 2018, In : Clinical Neurosurgery. 82, 5, p. E113-E114

Research output: Contribution to journalShort survey

Glioblastoma
Stem Cells
Zika Virus
2017

3K3A-Activated protein c and implanted neural stem cells stimulate repair and functional recovery after ischemic stroke

Strebe, J. K., Lubin, J. A. & Kuo, J., Sep 1 2017, In : Clinical Neurosurgery. 81, 3, p. N20-N21

Research output: Contribution to journalComment/debate

Neural Stem Cells
Stroke
Proteins
9 Citations (Scopus)

Acid ceramidase and its inhibitors: A de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency

Doan, N. B., Alhajala, H., Al-Gizawiy, M. M., Mueller, W. M., Rand, S. D., Connelly, J. M., Cochran, E. J., Chitambar, C. R., Clark, P., Kuo, J., Schmainda, K. M. & Mirza, S. P., Jan 1 2017, In : Oncotarget. 8, 68, p. 112662-112674 13 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Neoplastic Stem Cells
Glioblastoma
Pharmaceutical Preparations
Stem Cells
5 Citations (Scopus)

Administration of non-torsadogenic human Ether-à-go-go-Related Gene inhibitors is associated with better survival for high hERG-expressing glioblastoma patients

Pointer, K. B., Clark, P. A., Eliceiri, K. W., Salamat, M. S., Robertson, G. A. & Kuo, J., Jan 1 2017, In : Clinical Cancer Research. 23, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Ether
Survival
Genes
Gene Expression
Programmed Cell Death 1 Receptor
Glioblastoma
Immunotherapy
Drug Therapy
9 Citations (Scopus)

Association of collagen architecture with glioblastoma patient survival

Pointer, K. B., Clark, P. A., Schroeder, A. B., Salamat, M. S., Eliceiri, K. W. & Kuo, J., Jun 1 2017, In : Journal of neurosurgery. 126, 6, p. 1812-1821 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Collagen
Survival
Heterografts
Brain Neoplasms
80 Citations (Scopus)

Beyond the margins: Real-time detection of cancer using targeted fluorophores

Zhang, R. R., Schroeder, A. B., Grudzinski, J. J., Rosenthal, E. L., Warram, J. M., Pinchuk, A. N., Eliceiri, K. W., Kuo, J. & Weichert, J. P., Jun 1 2017, In : Nature Reviews Clinical Oncology. 14, 6, p. 347-364 18 p.

Research output: Contribution to journalReview article

Optical Imaging
Technology
Neoplasms
Biomarkers
Fluorescence

Chronic D609 treatment interferes with cell cycle and targets the expression of Olig2 in Glioma Stem like Cells

Kalluri, H. S. G., Kuo, J. & Dempsey, R. J., Nov 5 2017, In : European Journal of Pharmacology. 814, p. 81-86 6 p.

Research output: Contribution to journalArticle

Glioma
Cell Cycle
Stem Cells
Intercellular Signaling Peptides and Proteins
G1 Phase
4 Citations (Scopus)

Human cytomegalovirus-infected glioblastoma cells display stem cell-like phenotypes

Liu, C., Clark, P. A., Kuo, J. & Kalejta, R. F., May 1 2017, In : mSphere. 2, 3, e00137-17.

Research output: Contribution to journalArticle

Glioblastoma
Cytomegalovirus
Stem Cells
temozolomide
Phenotype
3 Citations (Scopus)

Impact of PET and MRI threshold-based tumor volume segmentation on patient-specific targeted radionuclide therapy dosimetry using CLR1404

Besemer, A. E., Titz, B., Grudzinski, J. J., Weichert, J. P., Kuo, J., Robins, H. I., Hall, L. T. & Bednarz, B. P., Jul 6 2017, In : Physics in Medicine and Biology. 62, 15, p. 6008-6025 18 p.

Research output: Contribution to journalArticle

Tumor Burden
Radioisotopes
Neoplasms
Brain Neoplasms
Therapeutics

Intracortical microstimulation of human somatosensory cortex reproduces touch in spinal cord injury patient

Lubin, J. A., Strebe, J. K. & Kuo, J., Jan 1 2017, In : Clinical Neurosurgery. 80, 5, p. N29-N30

Research output: Contribution to journalShort survey

Somatosensory Cortex
Touch
Spinal Cord Injuries

Reduced H3K27me3 is a New Epigenetic Biomarker for Pediatric Posterior Fossa Ependymomas

Zhang, R. R. & Kuo, J., Jul 1 2017, In : Neurosurgery. 81, 1, p. N7-N8

Research output: Contribution to journalComment/debate

Ependymoma
Epigenomics
Biomarkers
Pediatrics
16 Citations (Scopus)

Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration

Clark, P. A., Bhattacharya, S., Elmayan, A., Darjatmoko, S. R., Thuro, B. A., Yan, M. B., Van Ginkel, P. R., Polans, A. S. & Kuo, J., May 1 2017, In : Journal of neurosurgery. 126, 5, p. 1448-1460 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Growth
Glioma
Injections
10 Citations (Scopus)

The effects of tumor treating fields and temozolomide in MGMT expressing and non-expressing patient-derived glioblastoma cells

Clark, P. A., Gaal, J. T., Strebe, J. K., Pasch, C. A., Deming, D. A., Kuo, J. & Robins, H. I., Feb 1 2017, In : Journal of Clinical Neuroscience. 36, p. 120-124 5 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Transferases
DNA
Neoplasms
24 Citations (Scopus)

The future of basic science in academic surgery

Keswani, S. G., Moles, C. M., Morowitz, M., Zeh, H., Kuo, J., Levine, M. H., Cheng, L. S., Hackam, D. J., Ahuja, N. & Goldstein, A. M., Jun 1 2017, In : Annals of Surgery. 265, 6, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Surgeons
Aptitude
Research
Pressure
1 Citation (Scopus)

The impact of intracranial tumor proximity to white matter tracts on morbidity and mortality: A retrospective diffusion tensor imaging study

Meyer, E. J., Gaggl, W., Gilloon, B., Swan, B., Greenstein, M., Voss, J., Hussain, N., Holdsworth, R. L., Nair, V. A., Meyerand, M. E., Kuo, J., Baskaya, M. K., Field, A. S. & Prabhakaran, V., Feb 1 2017, In : Neurosurgery. 80, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Morbidity
Mortality
Pyramidal Tracts
Neoplasms
3 Citations (Scopus)

Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells

Zorniak, M., Clark, P. A., Umlauf, B. J., Cho, Y., Shusta, E. V. & Kuo, J., Dec 1 2017, In : Scientific reports. 7, 1, 15840.

Research output: Contribution to journalArticle

Glioblastoma
Stem Cells
Yeasts
Antibodies
Single-Domain Antibodies
2016
11 Citations (Scopus)

Analysis of cancer-targeting alkylphosphocholine analogue permeability characteristics using a human induced pluripotent stem cell blood-brain barrier model

Clark, P. A., Al-Ahmad, A. J., Qian, T., Zhang, R. R., Wilson, H. K., Weichert, J. P., Palecek, S. P., Kuo, J. & Shusta, E. V., Sep 6 2016, In : Molecular Pharmaceutics. 13, 9, p. 3341-3349 9 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Blood-Brain Barrier
Permeability
Neoplasms
Fluorescence
3 Citations (Scopus)

Bioresorbable Silicon Electronic Sensors for the Brain

Zhang, R. R., Lubin, J. A. & Kuo, J., Oct 1 2016, In : Neurosurgery. 79, 4, p. N19

Research output: Contribution to journalComment/debate

Silicon
Brain

Chemical Control of Grafted Human Pluripotent Stem Cell-Derived Neurons in a Mouse Parkinson Disease Model

Lubin, J. A., Strebe, J. & Kuo, J., Oct 1 2016, In : Neurosurgery. 79, 4, p. N18-N19

Research output: Contribution to journalComment/debate

Pluripotent Stem Cells
Parkinson Disease
Neurons

Comment

Zhang, R. R., Weichert, J. P. & Kuo, J., Dec 1 2016, In : Neurosurgery. 79, 6, 1 p.

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Management of Patients with Nonfunctioning Pituitary Adenomas: Executive Summary

Aghi, M. K., Chen, C. C., Fleseriu, M., Newman, S. A., Lucas, J. W., Kuo, J., Barkhoudarian, G., Farrell, C. J., Sheehan, J., Ziu, M. & Dunn, I. F., Oct 1 2016, In : Neurosurgery. 79, 4, p. 521-523 3 p.

Research output: Contribution to journalReview article

Pituitary Neoplasms
Guidelines
Advisory Committees
Residual Neoplasm
Neuronavigation
16 Citations (Scopus)

CSF1 overexpression promotes high-grade glioma formation without impacting the polarization status of glioma-associated microglia and macrophages

De, I., Steffen, M. D., Clark, P. A., Patros, C. J., Sokn, E., Bishop, S. M., Litscher, S., Maklakova, V. I., Kuo, J., Rodriguez, F. J. & Collier, L. S., May 1 2016, In : Cancer Research. 76, 9, p. 2552-2560 9 p.

Research output: Contribution to journalArticle

Microglia
Glioma
Macrophages
Glioblastoma
Cell Line
1 Citation (Scopus)

Detection of human brain tumor infiltration with quantitative stimulated raman scattering microscopy

Zhang, R. R. & Kuo, J., Apr 1 2016, In : Neurosurgery. 78, 4, p. N9-N11

Research output: Contribution to journalComment/debate

Raman Spectrum Analysis
Brain Neoplasms
Microscopy
6 Citations (Scopus)
Brain
Neoplasms
Multimodal Imaging
Therapeutics
Diagnostic Imaging
6 Citations (Scopus)

Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies

Zhang, R. R., Swanson, K. I., Hall, L. T., Weichert, J. P. & Kuo, J. S., Oct 1 2016, In : CNS oncology. 5, 4, p. 223-231 9 p.

Research output: Contribution to journalArticle

Brain
Neoplasms
Multimodal Imaging
Therapeutics
Diagnostic Imaging
3 Citations (Scopus)

Effect of D609 on the expression of GADD45β protein: Potential inhibitory role in the growth of glioblastoma cancer stem like cells

Kalluri, H. S. G., Kuo, J. & Dempsey, R. J., Jan 1 2016, In : European Journal of Pharmacology. 791, p. 510-517 8 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioblastoma
Glioma
Stem Cells
p38 Mitogen-Activated Protein Kinases
27 Citations (Scopus)

Focused ultrasound enhances central nervous system delivery of Bevacizumab for malignant glioma treatment

Liu, H. L., Hsu, P. H., Lin, C. Y., Huang, C. W., Chai, W. Y., Chu, P. C., Huang, C. Y., Chen, P. Y., Yang, L. Y., Kuo, J. & Wei, K. C., Oct 1 2016, In : Radiology. 281, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

Glioma
Central Nervous System
Magnetic Resonance Imaging
Therapeutics
Bevacizumab
24 Citations (Scopus)

Glioma-mediated microglial activation promotes glioma proliferation and migration: Roles of Na + /H + exchanger isoform

Zhu, W., Carney, K. E., Pigott, V. M., Falgoust, L. M., Clark, P. A., Kuo, J. & Sun, D., Sep 1 2016, In : Carcinogenesis. 37, 9, p. 839-851 13 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Glioma
Protein Isoforms
Microglia
Up-Regulation
19 Citations (Scopus)

Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Surgical Techniques and Technologies for the Management of Patients with Nonfunctioning Pituitary Adenomas

Kuo, J., Barkhoudarian, G., Farrell, C. J., Bodach, M. E., Tumialan, L. M., Oyesiku, N. M., Litvack, Z., Zada, G., Patil, C. G. & Aghi, M. K., Oct 1 2016, In : Neurosurgery. 79, 4, p. E536-E538

Research output: Contribution to journalReview article

Pituitary Neoplasms
Neuronavigation
Guidelines
Technology
Cerebrospinal Fluid
2 Citations (Scopus)

Heparan sulfates promote amyloid pathology in Alzheimer disease

Zhang, R. R., Strebe, J. K. & Kuo, J., Aug 1 2016, In : Neurosurgery. 79, 2, p. N12-N13

Research output: Contribution to journalShort survey

Heparitin Sulfate
Amyloid
Alzheimer Disease
Pathology

Iatrogenic intracranial placement of nasopharyngeal airway after trauma

Swanson, K. I., Nickele, C. M. & Kuo, J., Jul 3 2016, In : British Journal of Neurosurgery. 30, 4, p. 448-449 2 p.

Research output: Contribution to journalArticle

Craniocerebral Trauma
Decompressive Craniectomy
Skull Fractures
Diabetes Insipidus
Skull Base

"Inhibiting the Inhibitors" to support axonal regeneration

Sharma, T., Alves, G. C. P. & Kuo, J., Feb 1 2016, In : Neurosurgery. 78, 2, p. N14-N16

Research output: Contribution to journalArticle

Class 2 Receptor-Like Protein Tyrosine Phosphatases
Chondroitin Sulfate Proteoglycans
Nerve Regeneration
Spinal Cord Injuries
Regeneration
4 Citations (Scopus)

"tag Team" Glioblastoma Therapy: Results from a Phase 1 Trial of Toca 511 and 5-Fluorocytosine for Recurrent High-Grade Glioma

Strebe, J. K., Lubin, J. A. & Kuo, J., Dec 1 2016, In : Neurosurgery. 79, 6, p. N18-N20

Research output: Contribution to journalComment/debate

Flucytosine
Glioblastoma
Glioma
Therapeutics

The enduring legacy of pioneering neuroscientist Dr. Jerzy Edwin Rose

Gaal, J. T., Stenerson, M. & Kuo, J., Nov 1 2016, In : Journal of Clinical Neuroscience. 33, p. 69-72 4 p.

Research output: Contribution to journalArticle

Nervous System
Auditory Cortex
Exploratory Behavior
Electrophysiology
Neurosciences