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Linda Noble is a professor in the Department of Neurology, and a professor in the Department of Psychology in the College of Natural Sciences.

Noble's research lab is focused on translational neuroscience research in the field of neurotrauma. Her team's overarching long-term objective is to develop targeted therapeutics that will improve recovery after traumatic spinal cord and pediatric brain injuries. This research relies on cellular, molecular and behavioral tools to identify key mechanisms underlying early cell injury that impair recovery processes in preclinical models of neurotrauma. This multifaceted approach has led to the discovery of new pharmacologic and stem-cell based therapeutics that ameliorate several key features of spinal cord injury; namely, bladder and locomotor dysfunction and central neuropathic pain.

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  • 2 Similar Profiles
Spinal Cord Injuries Medicine & Life Sciences
Wounds and Injuries Medicine & Life Sciences
Spinal Cord Medicine & Life Sciences
Brain Medicine & Life Sciences
Heme Oxygenase-1 Medicine & Life Sciences
Neuroglia Medicine & Life Sciences
Brain Injuries Medicine & Life Sciences
Matrix Metalloproteinase 9 Medicine & Life Sciences

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Research Output 1983 2019

2 Citations (Scopus)

Matrix metalloproteinase signals following neurotrauma are right on cue

Trivedi, A., Noble, L., Levine, J. M., Santucci, A. D., Reeves, T. M. & Phillips, L. L., Aug 1 2019, In : Cellular and Molecular Life Sciences. 76, 16, p. 3141-3156 16 p.

Research output: Contribution to journalReview article

Matrix Metalloproteinases
Cues
Spinal Cord Injuries
Brain
Olfactory Bulb

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Munji, R. N., Soung, A. L., Weiner, G. A., Sohet, F., Semple, B. D., Trivedi, A., Gimlin, K., Kotoda, M., Korai, M., Aydin, S., Batugal, A., Cabangcala, A. C., Schupp, P. G., Oldham, M. C., Hashimoto, T., Noble-Haeusslein, L. J. & Daneman, R., Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1892-1902 11 p.

Research output: Contribution to journalArticle

Transcriptome
Endothelial Cells
Health
Brain
Gene Expression

The emerging role of neutrophils as modifiers of recovery after traumatic injury to the developing brain

von Leden, R. E., Parker, K. N., Bates, A. A., Noble-Haeusslein, L. J. & Donovan, M. H., Jul 2019, In : Experimental Neurology. 317, p. 144-154 11 p.

Research output: Contribution to journalReview article

Neutrophils
Wounds and Injuries
Brain
Leukocytes
Cytokines
7 Citations (Scopus)

Early targeting of L-selectin on leukocytes promotes recovery after spinal cord injury, implicating novel mechanisms of pathogenesis

McCreedy, D. A., Lee, S., Sontag, C. J., Weinstein, P., Olivas, A. D., Martinez, A. F., Fandel, T. M., Trivedi, A., Lowell, C. A., Rosen, S. D. & Noble-Haeusslein, L. J., Jul 1 2018, In : eNeuro. 5, 4, e0101-18.2018.

Research output: Contribution to journalArticle

L-Selectin
Spinal Cord Injuries
Leukocytes
Diclofenac
Myeloid Cells
15 Citations (Scopus)

Pre-clinical testing of therapies for traumatic brain injury

DeWitt, D. S., Hawkins, B. E., Dixon, C. E., Kochanek, P. M., Armstead, W., Bass, C. R., Bramlett, H. M., Buki, A., Dietrich, W. D., Ferguson, A. R., Hall, E. D., Hayes, R. L., Hinds, S. R., Laplaca, M. C., Long, J. B., Meaney, D. F., Mondello, S., Noble-Haeusslein, L. J., Poloyac, S. M., Prough, D. S. & 8 others, Robertson, C. S., Saatman, K. E., Shultz, S. R., Shear, D. A., Smith, D. H., Valadka, A. B., Vandevord, P. & Zhang, L., Dec 1 2018, In : Journal of neurotrauma. 35, 23, p. 2737-2754 18 p.

Research output: Contribution to journalArticle

Therapeutics
Consensus
Research Personnel
Guidelines
Investigational Therapies