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Personal profile

Research Interests

Cardiovascular biomechanics; computational simulation of the behavior of the cardiovascular system; advanced constitutive models, biomechanical interactions of cell, tissue, and organ in native and engineered heart valves and myocardium.


Professor Michael Sacks is the W. A. "Tex" Moncrief, Jr. Simulation-Based Engineering Science Chair and a world authority on cardiovascular biomechanics. His research focuses on modeling and simulation on the mechanical behavior and function of the heart and native and replacement heart valves He is also active in the biomechanics of engineered tissues, and in understanding the in-vitro and in-vivo remodeling processes from a functional biomechanical perspective. Dr. Sacks is currently director of the ICES Center for Cardiovascular Simulation and Professor of Biomedical Engineering. His research includes multi-scale studies of cell/tissue/organ mechanical interactions in heart valves and is particularly interested in determining the local stress environment for heart valve interstitial cells. Recent research has included developing novel multi-scale models of the mitral and bioprosthetic heart valves, as well as ventricular myocardium that allow for the separation of the individual contributions of the myocyte and connective tissue networks. His work is built on the structure-mechanical properties of native and engineered cardiovascular soft tissues, including scaffolds and multi-scale tissue-continuum cell models.

Selected Recognitions:
Fellow, American Society of Mechanical Engineers
Fellow (Inaugural), Biomedical Engineering Society
Fellow, American Institute for Medical and Biological Engineering
Van C. Mow Medal, American Society for Mechanical Engineers Bioengineering
Chancellor's Distinguished Research Award, University of Pittsburgh
Former Editor of the Journal of Biomechanical Engineering

Ph.D., Biomedical Engineering, UT Southwestern Medical Center at Dallas
M.S., Engineering Mechanics, Michigan State University
B.S. Engineering Mechanics, Michigan State University

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  • 4 Similar Profiles
Tissue Engineering & Materials Science
Heart Valves Medicine & Life Sciences
Collagen Engineering & Materials Science
Fibers Engineering & Materials Science
Constitutive models Engineering & Materials Science
Scaffolds Engineering & Materials Science
Aortic Valve Medicine & Life Sciences
Mitral Valve Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1983 2019

2 Citations (Scopus)

A Computational Cardiac Model for the Adaptation to Pulmonary Arterial Hypertension in the Rat

Avazmohammadi, R., Mendiola, E. A., Soares, J. S., Li, D. S., Chen, Z., Merchant, S., Hsu, E. W., Vanderslice, P., Dixon, R. A. F. & Sacks, M. S., Jan 15 2019, In : Annals of Biomedical Engineering. 47, 1, p. 138-153 16 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A Contemporary Look at Biomechanical Models of Myocardium

Avazmohammadi, R., Soares, J. S., Li, D. S., Raut, S. S., Gorman, R. C. & Sacks, M. S., Jan 1 2019, In : Annual Review of Biomedical Engineering. 21, p. 417-442 26 p.

Research output: Contribution to journalReview article

Constitutive models
4 Citations (Scopus)

A material modeling approach for the effective response of planar soft tissues for efficient computational simulations

Zhang, W., Zakerzadeh, R., Zhang, W. & Sacks, M. S., Jan 1 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 89, p. 168-198 31 p.

Research output: Contribution to journalArticle

Constitutive models
Parameter estimation
Computational efficiency

Analyzing valve interstitial cell mechanics and geometry with spatial statistics

Lejeune, E. & Sacks, M. S., Aug 27 2019, In : Journal of Biomechanics. 93, p. 159-166 8 p.

Research output: Contribution to journalArticle

Atomic force microscopy

A preliminary study of the local biomechanical environment of liver tumors in vivo

Ma, S., Zhu, M., Xia, X., Guo, L., Genin, G. M., Sacks, M. S., Gao, M., Mutic, S., Hu, Y., Hu, C. H. & Feng, Y., Apr 1 2019, In : Medical Physics. 46, 4, p. 1728-1739 12 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Tumor Biomarkers