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Research Output 1973 2019

2019

110th Anniversary: Nanoparticle Mediated Drug Delivery for the Treatment of Alzheimer's Disease: Crossing the Blood-Brain Barrier

Wechsler, M. E., Vela Ramirez, J. E. & Peppas, N., Jan 1 2019, (Accepted/In press) In : Industrial and Engineering Chemistry Research.

Research output: Contribution to journalArticle

Drug delivery
Nanoparticles
Pharmaceutical Preparations
Brain
Pharmacodynamics
3 Citations (Scopus)

3D cell-laden polymers to release bioactive products in the eye

Orive, G., Santos-Vizcaino, E., Pedraz, J. L., Hernandez, R. M., Vela Ramirez, J. E., Dolatshahi-Pirouz, A., Khademhosseini, A., Peppas, N. & Emerich, D. F., Jan 1 2019, In : Progress in Retinal and Eye Research. 68, p. 67-82 16 p.

Research output: Contribution to journalReview article

Polymers
Equipment Design
Aptitude
Genetic Engineering
Biocompatible Materials

Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization

Clegg, J. R., Sun, J. A., Ander, E. W., Venkataraman, A. & Peppas, N., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanostructures
Emulsion polymerization
Emulsions
Nanostructured materials
Polymerization
Open Access
Regenerative Medicine
Translational Medical Research
Medicine
Polymers
Financial Support
Open Access
Atom transfer radical polymerization
Emulsion polymerization
Polyethylene glycols
Polymers
Cytology
National Institute of Biomedical Imaging and Bioengineering (U.S.)
National Institutes of Health (U.S.)
Emotions
Vaccines
Research
2 Citations (Scopus)

Cytoplasmic delivery of functional siRNA using pH-Responsive nanoscale hydrogels

Liechty, W. B., Scheuerle, R. L., Vela Ramirez, J. E. & Peppas, N., May 1 2019, In : International journal of pharmaceutics. 562, p. 249-257 9 p.

Research output: Contribution to journalArticle

Hydrogels
Small Interfering RNA
Nanoparticles
Gene Knockdown Techniques
Virus Diseases

Development of polymeric nanogels for tear biomarker detection

Wechsler, M. E., Jocelyn Dang, H. K. H., Simmonds, S. P. & Peppas, N., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biomarkers
Tears
Signs and Symptoms
Exocrine Glands
Biosensing Techniques
3 Citations (Scopus)

Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing

Wechsler, M. E., Stephenson, R. E., Murphy, A. C., Oldenkamp, H. F., Singh, A. & Peppas, N., Jun 1 2019, In : Biomedical Microdevices. 21, 2, 31.

Research output: Contribution to journalArticle

Hydrogels
Cell- and Tissue-Based Therapy
Drug delivery
Pharmaceutical Preparations
Drug Carriers
1 Citation (Scopus)

Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices

Clegg, J. R., Wagner, A. M., Shin, S. R., Hassan, S., Khademhosseini, A. & Peppas, N., Jan 1 2019, In : Progress in Materials Science. 100589.

Research output: Contribution to journalReview article

Intelligent materials
Biomimetics
Tissue
Fabrication
Printing

Ph-responsive polymeric nanoparticles for the oral delivery of high isoelectric point therapeutic proteins

Oldenkamp, H. F., Koetting, M. C. & Peppas, N., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Isoelectric Point
Nanoparticles
Proteins
Therapeutics
Small Intestine
7 Citations (Scopus)

Quantum dots in biomedical applications

Wagner, A. M., Knipe, J. M., Orive, G. & Peppas, N., Aug 1 2019, In : Acta Biomaterialia. 94, p. 44-63 20 p.

Research output: Contribution to journalReview article

Quantum Dots
Semiconductor quantum dots
Imaging techniques
Drug delivery
Nanoparticles
2 Citations (Scopus)

Re-evaluating the importance of carbohydrates as regenerative biomaterials

Oldenkamp, H. F., Vela Ramirez, J. E. & Peppas, N. A., Jan 1 2019, In : Regenerative Biomaterials. 6, 1, p. 1-12 12 p., rby023.

Research output: Contribution to journalArticle

Open Access
Biocompatible Materials
Polysaccharides
Carbohydrates
Tissue engineering
Biomaterials
1 Citation (Scopus)

Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury, K., Russell, C. S., Sanchez-Gonzalez, L., Mostafavi, A., Williams, T. J., Kahn, C., Peppas, N. A., Arab-Tehrany, E. & Tamayol, A., Sep 1 2019, In : Advanced Healthcare Materials. 8, 18, 1900506.

Research output: Contribution to journalReview article

Hydrogels
Tissue Engineering
Tissue engineering
Nanoparticles
Scaffolds (biology)
1 Citation (Scopus)

Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications

Clegg, J. R., Irani, A. S., Ander, E. W., Ludolph, C. M., Venkataraman, A. K., Zhong, J. X. & Peppas, N. A., Sep 27 2019, In : Science Advances. 5, 9, eaax7946.

Research output: Contribution to journalArticle

Open Access
biodegradation
medicine
biomarkers
methylene blue
disulfides
1 Citation (Scopus)

Transport and delivery of interferon-α through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles

Caldorera-Moore, M., Vela Ramirez, J. E. & Peppas, N., Jul 3 2019, In : Journal of Drug Targeting. 27, 5-6, p. 582-589 8 p.

Research output: Contribution to journalArticle

Tight Junctions
Interferon-alpha
Nanoparticles
Interferons
Neoplasms
2 Citations (Scopus)

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Richbourg, N. R., Peppas, N. & Sikavitsas, V. I., Jan 1 2019, In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journalReview article

Biomimetics
Regenerative Medicine
Tissue Engineering
Scaffolds (biology)
Tissue engineering
2018
12 Citations (Scopus)

Advanced architectures in the design of responsive polymers for cancer nanomedicine

Wagner, A. M., Spencer, D. S. & Peppas, N. A., Jun 20 2018, In : Journal of Applied Polymer Science. 135, 24, 46154.

Research output: Contribution to journalReview article

Medical nanotechnology
Oncology
Polymers
Nanoparticles
Functional materials
48 Citations (Scopus)

Bone tissue engineering via growth factor delivery: From scaffolds to complex matrices

De Witte, T. M., Fratila-Apachitei, L. E., Zadpoor, A. A. & Peppas, N. A., Jan 1 2018, In : Regenerative Biomaterials. 5, 4, p. 197-211 15 p.

Research output: Contribution to journalArticle

Open Access
Scaffolds (biology)
Tissue engineering
Intercellular Signaling Peptides and Proteins
Bone
Scaffolds
8 Citations (Scopus)

Combination strategy with complexation hydrogels and cell-penetrating peptides for oral delivery of insulin

Fukuoka, Y., Khafagy, E. S., Goto, T., Kamei, N., Takayama, K., Peppas, N. A. & Takeda-Morishita, M., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 5, p. 811-814 4 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Hydrogels
Insulin
Ethylene Glycol
Arginine
3 Citations (Scopus)

Control of cationic nanogel PEGylation in heterogeneous ARGET ATRP emulsion polymerization with PEG macromonomers

Spencer, D. S., Luu, B. C., Beckman, D. W. & Peppas, N. A., Jul 15 2018, In : Journal of Polymer Science, Part A: Polymer Chemistry. 56, 14, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

Atom transfer radical polymerization
Emulsion polymerization
Polyethylene glycols
Surface active agents
Surface-Active Agents

Correction to: PH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles (Biomacromolecules (2018) 19:3 (793-802) DOI: 10.1021/acs.biomac.7b01590)

Sharpe, L. A., Vela Ramirez, J. E., Haddadin, O. M., Ross, K. A., Narasimhan, B. & Peppas, N. A., Sep 10 2018, In : Biomacromolecules. 19, 9, 1 p.

Research output: Contribution to journalComment/debate

Polyanhydrides
Microencapsulation
Nanoparticles
Polymers
Health
Proteins
25 Citations (Scopus)

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

Wagner, A. M., Gran, M. P. & Peppas, N., Mar 1 2018, In : Acta Pharmaceutica Sinica B. 8, 2, p. 147-164 18 p.

Research output: Contribution to journalReview article

Carrier Proteins
Peptides
Injections
Patient Compliance
Gastrointestinal Tract

Erratum: PH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Sharpe, L. A., Vela Ramirez, J. E., Haddadin, O. M., Ross, K. A., Narasimhan, B. & Peppas, N. A., Jan 1 2018, (Accepted/In press) In : Biomacromolecules.

Research output: Contribution to journalArticle

Microencapsulation
Nanoparticles
1 Citation (Scopus)
Hydrogels
Intelligent materials
Drug delivery
12 Citations (Scopus)

Label-Free Detection of Tear Biomarkers Using Hydrogel-Coated Gold Nanoshells in a Localized Surface Plasmon Resonance-Based Biosensor

Culver, H. R., Wechsler, M. E. & Peppas, N. A., Sep 25 2018, In : ACS Nano. 12, 9, p. 9342-9354 13 p.

Research output: Contribution to journalArticle

Nanoshells
biomarkers
Hydrogel
Surface plasmon resonance
Biomarkers
12 Citations (Scopus)

PH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Sharpe, L. A., Vela Ramirez, J. E., Haddadin, O. M., Ross, K. A., Narasimhan, B. & Peppas, N. A., Jan 1 2018, In : Biomacromolecules. 19, 3, p. 793-802 10 p.

Research output: Contribution to journalArticle

Polyanhydrides
Microencapsulation
Nanoparticles
Ovalbumin
Encapsulation
9 Citations (Scopus)

Synthesis and characterization of poly(N-isopropyl methacrylamide) core/shell nanogels for controlled release of chemotherapeutics

Peters, J. T., Hutchinson, S. S., Lizana, N., Verma, I. & Peppas, N., May 15 2018, In : Chemical Engineering Journal. 340, p. 58-65 8 p.

Research output: Contribution to journalArticle

drug
shell
Drug delivery
coating
Coatings
6 Citations (Scopus)

Tunable poly(methacrylic acid-co-acrylamide) nanoparticles through inverse emulsion polymerization

Zhong, J. X., Clegg, J. R., Ander, E. W. & Peppas, N., Jun 1 2018, In : Journal of Biomedical Materials Research - Part A. 106, 6, p. 1677-1686 10 p.

Research output: Contribution to journalArticle

Acrylamide
Emulsion polymerization
Nanoparticles
Acids
Hydrogel
6 Citations (Scopus)

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

Sainz, V., Moura, L. I. F., Peres, C., Matos, A. I., Viana, A. S., Wagner, A. M., Vela Ramirez, J. E., S. Barata, T., Gaspar, M., Brocchini, S., Zloh, M., Peppas, N. A., Satchi-Fainaro, R. & F. Florindo, H., Aug 2018, In : Acta Biomaterialia. 76, p. 193-207 15 p.

Research output: Contribution to journalArticle

Galactosylceramides
Vaccines
Peptides
Tumors
Melanoma
2017
124 Citations (Scopus)

Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Culver, H. R., Clegg, J. R. & Peppas, N. A., Feb 21 2017, In : Accounts of Chemical Research. 50, 2, p. 170-178 9 p.

Research output: Contribution to journalArticle

Hydrogels
Intelligent materials
Drug delivery
Molecular recognition
Biomolecules
8 Citations (Scopus)

Characterization of protein interactions with molecularly imprinted hydrogels that possess engineered affinity for high isoelectric point biomarkers

Clegg, J. R., Zhong, J. X., Irani, A. S., Gu, J., Spencer, D. S. & Peppas, N. A., Jun 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 6, p. 1565-1574 10 p.

Research output: Contribution to journalArticle

Hydrogels
Biomarkers
Proteins
Polymers
Cytochromes c
13 Citations (Scopus)

Charged poly(: N -isopropylacrylamide) nanogels for use as differential protein receptors in a turbidimetric sensor array

Culver, H. R., Sharma, I., Wechsler, M. E., Anslyn, E. V. & Peppas, N. A., Sep 7 2017, In : Analyst. 142, 17, p. 3183-3193 11 p.

Research output: Contribution to journalArticle

Sensor arrays
Turbidity
sensor
Proteins
turbidity
12 Citations (Scopus)

Complexation hydrogels as potential carriers in oral vaccine delivery systems

Yoshida, M., Kamei, N., Muto, K., Kunisawa, J., Takayama, K., Peppas, N. A. & Takeda-Morishita, M., Mar 1 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 112, p. 138-142 5 p.

Research output: Contribution to journalArticle

Hydrogels
Cholera Toxin
Hydrogel
Vaccines
Ovalbumin
44 Citations (Scopus)

Current state and challenges in developing oral vaccines

Vela Ramirez, J. E., Sharpe, L. A. & Peppas, N. A., May 15 2017, In : Advanced Drug Delivery Reviews. 114, p. 116-131 16 p.

Research output: Contribution to journalReview article

Vaccines
Humoral Immunity
Cellular Immunity
Compliance
Communicable Diseases
9 Citations (Scopus)
Hydrogels
Hydrogel
Proteins
Chemical analysis
Polyethylene glycols
13 Citations (Scopus)

Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications

Neves, M. I., Wechsler, M. E., Gomes, M. E., Reis, R. L., Granja, P. L. & Peppas, N. A., Feb 2017, In : Tissue Engineering - Part B: Reviews. 23, 1, p. 27-43 17 p.

Research output: Contribution to journalReview article

Molecular Imprinting
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Hydrogels
23 Citations (Scopus)

Protein-Imprinted Polymers: The Shape of Things to Come?

Culver, H. R. & Peppas, N. A., Jul 25 2017, In : Chemistry of Materials. 29, 14, p. 5753-5761 9 p.

Research output: Contribution to journalArticle

Polymers
Proteins
Molecular recognition
Hydrogel
Free radical polymerization
3 Citations (Scopus)

Recent advances in hemophilia B therapy

Horava, S. D. & Peppas, N. A., Jun 1 2017, In : Drug Delivery and Translational Research. 7, 3, p. 359-371 13 p.

Research output: Contribution to journalReview article

Hemophilia B
Factor IX
Therapeutics
Drug Delivery Systems
Patient Compliance
1 Citation (Scopus)

Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide) based nanogels

Peters, J. T., Verghese, S., Subramanian, D. & Peppas, N. A., Oct 1 2017, In : Regenerative Biomaterials. 4, 5, p. 281-287 7 p.

Research output: Contribution to journalArticle

Open Access
Hydrolysis
Proteins
Adsorption
Gels
Hydrogels
8 Citations (Scopus)

Vision for Functionally Decorated and Molecularly Imprinted Polymers in Regenerative Engineering

Clegg, J. R., Wechsler, M. E. & Peppas, N. A., Sep 1 2017, In : Regenerative Engineering and Translational Medicine. 3, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

Polymers
Molecular Imprinting
Developmental Biology
Nerve Regeneration
Bone Regeneration
2016
18 Citations (Scopus)

A Closer Look at the Impact of Molecular Imprinting on Adsorption Capacity and Selectivity for Protein Templates

Culver, H. R., Steichen, S. D. & Peppas, N. A., Dec 12 2016, In : Biomacromolecules. 17, 12, p. 4045-4053 9 p.

Research output: Contribution to journalArticle

Polymers
Muramidase
Proteins
Adsorption
Enzymes
10 Citations (Scopus)

Biodegradable hydrophilic carriers for the oral delivery of hematological factor IX for hemophilia B treatment

Horava, S. D., Moy, K. J. & Peppas, N. A., Nov 30 2016, In : International journal of pharmaceutics. 514, 1, p. 220-228 9 p.

Research output: Contribution to journalArticle

Hemophilia B
Factor IX
Peptides
Polymers
Therapeutics
10 Citations (Scopus)

Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX

Horava, S. D. & Peppas, N., Jun 1 2016, In : Annals of Biomedical Engineering. 44, 6, p. 1970-1982 13 p.

Research output: Contribution to journalArticle

Biomaterials
Hydrogels
Polyethylene glycols
Acids
Ionic strength
45 Citations (Scopus)

Enzyme- and pH-Responsive Microencapsulated Nanogels for Oral Delivery of siRNA to Induce TNF-α Knockdown in the Intestine

Knipe, J. M., Strong, L. E. & Peppas, N. A., Mar 14 2016, In : Biomacromolecules. 17, 3, p. 788-797 10 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Enzymes
Acids
Degradation
Macrophages
40 Citations (Scopus)

Hydrogel-based biosensors and sensing devices for drug delivery

Peppas, N. & Van Blarcom, D. S., Oct 28 2016, In : Journal of Controlled Release. 240, p. 142-150 9 p.

Research output: Contribution to journalArticle

Hydrogel
Biosensing Techniques
Equipment and Supplies
Hydrogels
Drug Delivery Systems
8 Citations (Scopus)

In Vitro Evaluation of pH-Responsive Nanoscale Hydrogels for the Oral Delivery of Hydrophobic Therapeutics

Puranik, A. S., Pao, L. P., White, V. M. & Peppas, N. A., Oct 12 2016, In : Industrial and Engineering Chemistry Research. 55, 40, p. 10576-10590 15 p.

Research output: Contribution to journalArticle

Hydrogels
Doxorubicin
Glycoproteins
Solubility
Polyethylene glycols