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Research Output 1973 2019

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2019

110th Anniversary: Nanoparticle Mediated Drug Delivery for the Treatment of Alzheimer's Disease: Crossing the Blood-Brain Barrier

Wechsler, M. E., Vela Ramirez, J. E. & Peppas, N., Jan 1 2019, (Accepted/In press) In : Industrial and Engineering Chemistry Research.

Research output: Contribution to journalArticle

Drug delivery
Nanoparticles
Pharmaceutical Preparations
Brain
Pharmacodynamics
2 Citations (Scopus)

Cytoplasmic delivery of functional siRNA using pH-Responsive nanoscale hydrogels

Liechty, W. B., Scheuerle, R. L., Vela Ramirez, J. E. & Peppas, N., May 1 2019, In : International journal of pharmaceutics. 562, p. 249-257 9 p.

Research output: Contribution to journalArticle

Hydrogels
Small Interfering RNA
Nanoparticles
Gene Knockdown Techniques
Virus Diseases
3 Citations (Scopus)

Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing

Wechsler, M. E., Stephenson, R. E., Murphy, A. C., Oldenkamp, H. F., Singh, A. & Peppas, N., Jun 1 2019, In : Biomedical Microdevices. 21, 2, 31.

Research output: Contribution to journalArticle

Hydrogels
Cell- and Tissue-Based Therapy
Drug delivery
Pharmaceutical Preparations
Drug Carriers
2 Citations (Scopus)

Re-evaluating the importance of carbohydrates as regenerative biomaterials

Oldenkamp, H. F., Vela Ramirez, J. E. & Peppas, N. A., Jan 1 2019, In : Regenerative Biomaterials. 6, 1, p. 1-12 12 p., rby023.

Research output: Contribution to journalArticle

Open Access
Biocompatible Materials
Polysaccharides
Carbohydrates
Tissue engineering
Biomaterials
1 Citation (Scopus)

Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications

Clegg, J. R., Irani, A. S., Ander, E. W., Ludolph, C. M., Venkataraman, A. K., Zhong, J. X. & Peppas, N. A., Sep 27 2019, In : Science Advances. 5, 9, eaax7946.

Research output: Contribution to journalArticle

Open Access
biodegradation
medicine
biomarkers
methylene blue
disulfides
1 Citation (Scopus)

Transport and delivery of interferon-α through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles

Caldorera-Moore, M., Vela Ramirez, J. E. & Peppas, N., Jul 3 2019, In : Journal of Drug Targeting. 27, 5-6, p. 582-589 8 p.

Research output: Contribution to journalArticle

Tight Junctions
Interferon-alpha
Nanoparticles
Interferons
Neoplasms
2018
48 Citations (Scopus)

Bone tissue engineering via growth factor delivery: From scaffolds to complex matrices

De Witte, T. M., Fratila-Apachitei, L. E., Zadpoor, A. A. & Peppas, N. A., Jan 1 2018, In : Regenerative Biomaterials. 5, 4, p. 197-211 15 p.

Research output: Contribution to journalArticle

Open Access
Scaffolds (biology)
Tissue engineering
Intercellular Signaling Peptides and Proteins
Bone
Scaffolds
8 Citations (Scopus)

Combination strategy with complexation hydrogels and cell-penetrating peptides for oral delivery of insulin

Fukuoka, Y., Khafagy, E. S., Goto, T., Kamei, N., Takayama, K., Peppas, N. A. & Takeda-Morishita, M., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 5, p. 811-814 4 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Hydrogels
Insulin
Ethylene Glycol
Arginine
3 Citations (Scopus)

Control of cationic nanogel PEGylation in heterogeneous ARGET ATRP emulsion polymerization with PEG macromonomers

Spencer, D. S., Luu, B. C., Beckman, D. W. & Peppas, N. A., Jul 15 2018, In : Journal of Polymer Science, Part A: Polymer Chemistry. 56, 14, p. 1536-1544 9 p.

Research output: Contribution to journalArticle

Atom transfer radical polymerization
Emulsion polymerization
Polyethylene glycols
Surface active agents
Surface-Active Agents

Erratum: PH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Sharpe, L. A., Vela Ramirez, J. E., Haddadin, O. M., Ross, K. A., Narasimhan, B. & Peppas, N. A., Jan 1 2018, (Accepted/In press) In : Biomacromolecules.

Research output: Contribution to journalArticle

Microencapsulation
Nanoparticles
12 Citations (Scopus)

Label-Free Detection of Tear Biomarkers Using Hydrogel-Coated Gold Nanoshells in a Localized Surface Plasmon Resonance-Based Biosensor

Culver, H. R., Wechsler, M. E. & Peppas, N. A., Sep 25 2018, In : ACS Nano. 12, 9, p. 9342-9354 13 p.

Research output: Contribution to journalArticle

Nanoshells
biomarkers
Hydrogel
Surface plasmon resonance
Biomarkers
12 Citations (Scopus)

PH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Sharpe, L. A., Vela Ramirez, J. E., Haddadin, O. M., Ross, K. A., Narasimhan, B. & Peppas, N. A., Jan 1 2018, In : Biomacromolecules. 19, 3, p. 793-802 10 p.

Research output: Contribution to journalArticle

Polyanhydrides
Microencapsulation
Nanoparticles
Ovalbumin
Encapsulation
9 Citations (Scopus)

Synthesis and characterization of poly(N-isopropyl methacrylamide) core/shell nanogels for controlled release of chemotherapeutics

Peters, J. T., Hutchinson, S. S., Lizana, N., Verma, I. & Peppas, N., May 15 2018, In : Chemical Engineering Journal. 340, p. 58-65 8 p.

Research output: Contribution to journalArticle

drug
shell
Drug delivery
coating
Coatings
6 Citations (Scopus)

Tunable poly(methacrylic acid-co-acrylamide) nanoparticles through inverse emulsion polymerization

Zhong, J. X., Clegg, J. R., Ander, E. W. & Peppas, N., Jun 1 2018, In : Journal of Biomedical Materials Research - Part A. 106, 6, p. 1677-1686 10 p.

Research output: Contribution to journalArticle

Acrylamide
Emulsion polymerization
Nanoparticles
Acids
Hydrogel
6 Citations (Scopus)

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

Sainz, V., Moura, L. I. F., Peres, C., Matos, A. I., Viana, A. S., Wagner, A. M., Vela Ramirez, J. E., S. Barata, T., Gaspar, M., Brocchini, S., Zloh, M., Peppas, N. A., Satchi-Fainaro, R. & F. Florindo, H., Aug 2018, In : Acta Biomaterialia. 76, p. 193-207 15 p.

Research output: Contribution to journalArticle

Galactosylceramides
Vaccines
Peptides
Tumors
Melanoma
2017
124 Citations (Scopus)

Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Culver, H. R., Clegg, J. R. & Peppas, N. A., Feb 21 2017, In : Accounts of Chemical Research. 50, 2, p. 170-178 9 p.

Research output: Contribution to journalArticle

Hydrogels
Intelligent materials
Drug delivery
Molecular recognition
Biomolecules
8 Citations (Scopus)

Characterization of protein interactions with molecularly imprinted hydrogels that possess engineered affinity for high isoelectric point biomarkers

Clegg, J. R., Zhong, J. X., Irani, A. S., Gu, J., Spencer, D. S. & Peppas, N. A., Jun 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 6, p. 1565-1574 10 p.

Research output: Contribution to journalArticle

Hydrogels
Biomarkers
Proteins
Polymers
Cytochromes c
13 Citations (Scopus)

Charged poly(: N -isopropylacrylamide) nanogels for use as differential protein receptors in a turbidimetric sensor array

Culver, H. R., Sharma, I., Wechsler, M. E., Anslyn, E. V. & Peppas, N. A., Sep 7 2017, In : Analyst. 142, 17, p. 3183-3193 11 p.

Research output: Contribution to journalArticle

Sensor arrays
Turbidity
sensor
Proteins
turbidity
12 Citations (Scopus)

Complexation hydrogels as potential carriers in oral vaccine delivery systems

Yoshida, M., Kamei, N., Muto, K., Kunisawa, J., Takayama, K., Peppas, N. A. & Takeda-Morishita, M., Mar 1 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 112, p. 138-142 5 p.

Research output: Contribution to journalArticle

Hydrogels
Cholera Toxin
Hydrogel
Vaccines
Ovalbumin
9 Citations (Scopus)
Hydrogels
Hydrogel
Proteins
Chemical analysis
Polyethylene glycols
23 Citations (Scopus)

Protein-Imprinted Polymers: The Shape of Things to Come?

Culver, H. R. & Peppas, N. A., Jul 25 2017, In : Chemistry of Materials. 29, 14, p. 5753-5761 9 p.

Research output: Contribution to journalArticle

Polymers
Proteins
Molecular recognition
Hydrogel
Free radical polymerization
1 Citation (Scopus)

Surface hydrolysis-mediated PEGylation of poly(N-isopropyl acrylamide) based nanogels

Peters, J. T., Verghese, S., Subramanian, D. & Peppas, N. A., Oct 1 2017, In : Regenerative Biomaterials. 4, 5, p. 281-287 7 p.

Research output: Contribution to journalArticle

Open Access
Hydrolysis
Proteins
Adsorption
Gels
Hydrogels
8 Citations (Scopus)

Vision for Functionally Decorated and Molecularly Imprinted Polymers in Regenerative Engineering

Clegg, J. R., Wechsler, M. E. & Peppas, N. A., Sep 1 2017, In : Regenerative Engineering and Translational Medicine. 3, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

Polymers
Molecular Imprinting
Developmental Biology
Nerve Regeneration
Bone Regeneration
2016
18 Citations (Scopus)

A Closer Look at the Impact of Molecular Imprinting on Adsorption Capacity and Selectivity for Protein Templates

Culver, H. R., Steichen, S. D. & Peppas, N. A., Dec 12 2016, In : Biomacromolecules. 17, 12, p. 4045-4053 9 p.

Research output: Contribution to journalArticle

Polymers
Muramidase
Proteins
Adsorption
Enzymes
10 Citations (Scopus)

Biodegradable hydrophilic carriers for the oral delivery of hematological factor IX for hemophilia B treatment

Horava, S. D., Moy, K. J. & Peppas, N. A., Nov 30 2016, In : International journal of pharmaceutics. 514, 1, p. 220-228 9 p.

Research output: Contribution to journalArticle

Hemophilia B
Factor IX
Peptides
Polymers
Therapeutics
10 Citations (Scopus)

Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX

Horava, S. D. & Peppas, N., Jun 1 2016, In : Annals of Biomedical Engineering. 44, 6, p. 1970-1982 13 p.

Research output: Contribution to journalArticle

Biomaterials
Hydrogels
Polyethylene glycols
Acids
Ionic strength
45 Citations (Scopus)

Enzyme- and pH-Responsive Microencapsulated Nanogels for Oral Delivery of siRNA to Induce TNF-α Knockdown in the Intestine

Knipe, J. M., Strong, L. E. & Peppas, N. A., Mar 14 2016, In : Biomacromolecules. 17, 3, p. 788-797 10 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Enzymes
Acids
Degradation
Macrophages
40 Citations (Scopus)

Hydrogel-based biosensors and sensing devices for drug delivery

Peppas, N. & Van Blarcom, D. S., Oct 28 2016, In : Journal of Controlled Release. 240, p. 142-150 9 p.

Research output: Contribution to journalArticle

Hydrogel
Biosensing Techniques
Equipment and Supplies
Hydrogels
Drug Delivery Systems
8 Citations (Scopus)

In Vitro Evaluation of pH-Responsive Nanoscale Hydrogels for the Oral Delivery of Hydrophobic Therapeutics

Puranik, A. S., Pao, L. P., White, V. M. & Peppas, N. A., Oct 12 2016, In : Industrial and Engineering Chemistry Research. 55, 40, p. 10576-10590 15 p.

Research output: Contribution to journalArticle

Hydrogels
Doxorubicin
Glycoproteins
Solubility
Polyethylene glycols
52 Citations (Scopus)
Hydrogel
salmon calcitonin
Therapeutic Uses
Proteolysis
Proteins
17 Citations (Scopus)

Synthesis and characterization of pH-responsive nanoscale hydrogels for oral delivery of hydrophobic therapeutics

Puranik, A. S., Pao, L. P., White, V. M. & Peppas, N. A., Nov 1 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 108, p. 196-213 18 p.

Research output: Contribution to journalArticle

Hydrogels
Polymers
P-Glycoprotein
Fourier Transform Infrared Spectroscopy
Therapeutics
12 Citations (Scopus)

Versatile Route to Colloidal Stability and Surface Functionalization of Hydrophobic Nanomaterials

Culver, H. R., Steichen, S. D., Herrera-Alonso, M. & Peppas, N., Jun 7 2016, In : Langmuir. 32, 22, p. 5629-5636 8 p.

Research output: Contribution to journalArticle

Nanostructured materials
Methacrylates
routes
Nanoparticles
nanoparticles
2015
9 Citations (Scopus)

Complexation Hydrogels as Oral Delivery Vehicles of Therapeutic Antibodies: An in Vitro and ex Vivo Evaluation of Antibody Stability and Bioactivity

Carrillo-Conde, B. R., Brewer, E., Lowman, A. & Peppas, N. A., Oct 28 2015, In : Industrial and Engineering Chemistry Research. 54, 42, p. 10197-10205 9 p.

Research output: Contribution to journalArticle

Hydrogels
Bioactivity
Complexation
Antibodies
Hydrogel
10 Citations (Scopus)

Dynamic swelling behavior of interpenetrating polymer networks in response to temperature and pH

Slaughter, B. V., Blanchard, A. T., Maass, K. F. & Peppas, N. A., Jun 1 2015, In : Journal of Applied Polymer Science. 132, 24, 42076.

Research output: Contribution to journalArticle

Interpenetrating polymer networks
Hydrogels
Swelling
carbopol 940
Temperature
36 Citations (Scopus)

Enzymatic Biodegradation of Hydrogels for Protein Delivery Targeted to the Small Intestine

Knipe, J. M., Chen, F. & Peppas, N. A., Mar 9 2015, In : Biomacromolecules. 16, 3, p. 962-972 11 p.

Research output: Contribution to journalArticle

Hydrogels
Biodegradation
Proteins
Degradation
Trypsin
6 Citations (Scopus)

Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents

Caldorera-Moore, M., Maass, K., Hegab, R., Fletcher, G. & Peppas, N., Dec 1 2015, In : Journal of Drug Delivery Science and Technology. 30, p. 352-359 8 p.

Research output: Contribution to journalArticle

Hydrogel
Molecular Weight
Hydrogels
Methacrylates
Therapeutics
2014
13 Citations (Scopus)

Multiresponsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nanogels

Knipe, J. M., Chen, F. & Peppas, N. A., Apr 5 2014, In : Journal of Applied Polymer Science. 131, 7, 40098.

Research output: Contribution to journalArticle

Hydrogels
Encapsulation
Swelling
Hydrogel
Titration
418 Citations (Scopus)

Nanocomposite hydrogels for biomedical applications

Gaharwar, A. K., Peppas, N. A. & Khademhosseini, A., Mar 1 2014, In : Biotechnology and Bioengineering. 111, 3, p. 441-453 13 p.

Research output: Contribution to journalArticle

Nanocomposites
Hydrogels
Hydrogel
Nanoparticles
Nanostructures
48 Citations (Scopus)
Hydrogels
Isoelectric Point
Osmolar Concentration
salmon calcitonin
Hydrogel
37 Citations (Scopus)

Polycationic nanoparticles for siRNA delivery: Comparing ARGET ATRP and UV-initiated formulations

Forbes, D. C. & Peppas, N. A., Mar 25 2014, In : ACS Nano. 8, 3, p. 2908-2917 10 p.

Research output: Contribution to journalArticle

Atom transfer radical polymerization
RNA
Small Interfering RNA
delivery
Nanoparticles
13 Citations (Scopus)

Polymeric nanocarriers for siRNA delivery to murine macrophages

Forbes, D. C. & Peppas, N., Jan 1 2014, In : Macromolecular Bioscience. 14, 8, p. 1096-1105 10 p.

Research output: Contribution to journalArticle

Macrophages
Small Interfering RNA
Atom transfer radical polymerization
Nanoparticles
Flow cytometry
38 Citations (Scopus)

Surface-modified P(HEMA-co-MAA) nanogel carriers for oral vaccine delivery: Design, characterization, and in vitro targeting evaluation

Durán-Lobato, M., Carrillo-Conde, B., Khairandish, Y. & Peppas, N., Jul 14 2014, In : Biomacromolecules. 15, 7, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

Mannans
Vaccines
Antigens
Macrophages
Carbohydrates
2013
5 Citations (Scopus)

Amphiphilic Interpenetrating Polymer Networks for the Oral Delivery of Chemotherapeutics

Schoener, C. A., Hutson, H. N. & Peppas, N. A., May 1 2013, In : AIChE Journal. 59, 5, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Interpenetrating polymer networks
Polymers
Small Intestine
Ethylene Glycol
Ethylene glycol
8 Citations (Scopus)

An inulin and doxorubicin conjugate for improving cancer therapy

Schoener, C. A., Carillo-Conde, B., Hutson, H. N. & Peppas, N., Jan 1 2013, In : Journal of Drug Delivery Science and Technology. 23, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

Inulin
Doxorubicin
Drug Therapy
Neoplasms
Confocal Microscopy
6 Citations (Scopus)

Differences in molecular structure in cross-linked polycationic nanoparticles synthesized using ARGET ATRP or UV-initiated polymerization

Forbes, D. C. & Peppas, N., Aug 2 2013, In : Polymer. 54, 17, p. 4486-4492 7 p.

Research output: Contribution to journalArticle

Atom transfer radical polymerization
Molecular structure
Polymerization
Nanoparticles
Methacrylates
15 Citations (Scopus)

Insulin release dynamics from poly(diethylaminoethyl methacrylate) hydrogel systems

Marek, S. R. & Peppas, N. A., Oct 1 2013, In : AIChE Journal. 59, 10, p. 3578-3585 8 p.

Research output: Contribution to journalArticle

Hydrogel
Insulin
Hydrogels
Crosslinking
Glucose
7 Citations (Scopus)

Investigation of the swelling behavior of dome matrix drug delivery modules by high-resolution x-ray computed tomography

Losi, E., Peppas, N., Ketcham, R. A., Colombo, G., Bettini, R., Sonvico, F. & Colombo, P., Jan 1 2013, In : Journal of Drug Delivery Science and Technology. 23, 2, p. 165-170 6 p.

Research output: Contribution to journalArticle

Gels
Tomography
X-Rays
Pharmaceutical Preparations
Polymers
7 Citations (Scopus)
Hydrogels
Polymethyl Methacrylate
Nanoparticles
Doxorubicin
Transport properties
34 Citations (Scopus)

PH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics

Schoener, C. A., Hutson, H. N. & Peppas, N., Aug 1 2013, In : Journal of Biomedical Materials Research - Part A. 101 A, 8, p. 2229-2236 8 p.

Research output: Contribution to journalArticle

Hydrogels
Polymers
Nanoparticles
Doxorubicin
Polymethyl Methacrylate