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Research Output 1983 2019

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Article
2019
3 Citations (Scopus)

A corticotropin releasing factor network in the extended amygdala for anxiety

Pomrenze, M. B., Tovar-Diaz, J., Blasio, A., Maiya, R., Giovanetti, S. M., Lei, K., Morikawa, H., Woodward Hopf, F. & Messing, R. O., Feb 6 2019, In : Journal of Neuroscience. 39, 6, p. 1030-1043 14 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone
Amygdala
Septal Nuclei
Anxiety
Neurons
2 Citations (Scopus)

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

de Guglielmo, G., Kallupi, M., Pomrenze, M. B., Crawford, E., Simpson, S., Schweitzer, P., Koob, G. F., Messing, R. O. & George, O., Dec 1 2019, In : Nature Communications. 10, 1, 1238.

Research output: Contribution to journalArticle

Open Access
Corticotropin-Releasing Hormone
releasing
deactivation
rats
Rats
1 Citation (Scopus)

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice

Warden, A. S., Azzam, M., DaCosta, A., Mason, S., Blednov, Y. A., Messing, R. O., Mayfield, R. D. & Harris, R. A., Mar 1 2019, In : Brain, Behavior, and Immunity. 77, p. 55-65 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Poly I-C
Alcohol Drinking
Alcohols
Drinking Behavior

Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake

Warden, A. S., Azzam, M., DaCosta, A., Mason, S., Blednov, Y. A., Messing, R. O., Mayfield, R. D. & Harris, R. A., Mar 1 2019, In : Brain, Behavior, and Immunity. 77, p. 66-76 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Inbred C57BL Mouse
Alcohols
Drinking Behavior
Ethanol
2018
3 Citations (Scopus)

Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference

Blednov, Y. A., Da Costa, A. J., Tarbox, T., Ponomareva, O., Messing, R. O. & Harris, R. A., May 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 5, p. 926-938 13 p.

Research output: Contribution to journalArticle

Ethanol
Phosphodiesterase 4 Inhibitors
Drinking
Saccharin
Brain
4 Citations (Scopus)
Ethanol
Righting Reflex
Lithium Chloride
Anti-Anxiety Agents
Inbred C57BL Mouse
2 Citations (Scopus)

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

Blasio, A., Wang, J., Wang, D., Varodayan, F. P., Pomrenze, M. B., Miller, J., Lee, A. M., McMahon, T., Gyawali, S., Wang, H. Y., Roberto, M., McHardy, S., Pleiss, M. A. & Messing, R. O., Aug 1 2018, In : Biological Psychiatry. 84, 3, p. 193-201 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Ethanol
Alcohol Drinking
Sucrose
Phosphotransferases
2016
9 Citations (Scopus)

PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model

He, Y., Wilkie, D. J., Nazari, J., Wang, R., Messing, R. O., DeSimone, J., Molokie, R. E. & Wang, Z. J., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 3053-3057 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Chronic Pain
Pain
Hyperalgesia
GABAergic Neurons
2 Citations (Scopus)

Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice

Maiya, R., McMahon, T., Wang, D., Kanter, B., Gandhi, D., Chapman, H. L., Miller, J. & Messing, R. O., Aug 1 2016, In : Neuropharmacology. 107, p. 40-48 9 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Ethanol
Phosphotransferases
Adenosine Triphosphate
Inhibition (Psychology)
2015
3 Citations (Scopus)

A selective role for Lmo4 in cue–reward learning

Maiya, R., Mangieri, R. A., Morrisett, R. A., Heberlein, U. & Messing, R. O., Jul 1 2015, In : Journal of Neuroscience. 35, 26, p. 9638-9647 10 p.

Research output: Contribution to journalArticle

Learning
Aptitude
Dopamine D2 Receptors
Pyramidal Cells
Nucleus Accumbens
32 Citations (Scopus)

A transgenic rat for investigating the anatomy and function of corticotrophin releasing factor circuits

Pomrenze, M. B., Millan, E. Z., Hopf, F. W., Keiflin, R., Maiya, R., Blasio, A., Dadgar, J., Kharazia, V., De Guglielmo, G., Crawford, E., Janak, P. H., George, O., Rice, K. C. & Messing, R. O., Jan 1 2015, In : Frontiers in Neuroscience. 9, DEC, 487.

Research output: Contribution to journalArticle

Transgenic Rats
Corticotropin-Releasing Hormone
Anatomy
Neurons
R 121919
30 Citations (Scopus)

D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

Seif, T., Simms, J. A., Lei, K., Wegner, S., Bonci, A., Messing, R. O. & Hopf, F. W., Sep 14 2015, In : Neuropsychopharmacology. 40, 10, p. 2357-2367 11 p.

Research output: Contribution to journalArticle

Cycloserine
Serine
Quinine
Alcohols
Alcohol Drinking
6 Citations (Scopus)

Generation and characterization of ATP analog-specific protein kinase Cδ

Kumar, V., Weng, Y. C., Geldenhuys, W. J., Wang, D., Han, X., Messing, R. O. & Chou, W. H., Jan 23 2015, In : Journal of Biological Chemistry. 290, 4, p. 1936-1951 16 p.

Research output: Contribution to journalArticle

Protein Kinase C
Adenosine Triphosphate
Adenine
Phosphotransferases
Cell signaling
4 Citations (Scopus)

Identification of lipocalin-2 as a PKCδ phosphorylation substrate in neutrophils

Weng, Y. C., Wang, G., Messing, R. O. & Chou, W. H., Mar 20 2015, In : Journal of Biomedical Science. 22, 1, 21.

Research output: Contribution to journalArticle

Lipocalins
Phosphorylation
Neutrophils
Substrates
Reperfusion Injury
7 Citations (Scopus)

Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors

Schuster, D. J., Metcalf, M. D., Kitto, K. F., Messing, R. O., Fairbanks, C. A. & Wilcox, G. L., Jan 1 2015, In : British Journal of Pharmacology. 172, 2, p. 642-653 12 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Analgesics
Ligands
Knockout Mice
9 Citations (Scopus)

PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization

Lee, A. M., Wu, D. F., Dadgar, J., Wang, D., McMahon, T. & Messing, R. O., Sep 1 2015, In : British Journal of Pharmacology. 172, 17, p. 4430-4441 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Cholinergic Receptors
Phosphorylation
Induced Hypothermia
Synaptosomes
2014
10 Citations (Scopus)

Deletion of Prkcz Increases Intermittent Ethanol Consumption in Mice

Lee, A. M., Zou, M. E., Lim, J. P., Stecher, J., Mcmahon, T. & Messing, R. O., Jan 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Ethanol
Drinking
Proteins
PC12 Cells
2013
27 Citations (Scopus)

Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area

Sparta, D. R., Hopf, F. W., Gibb, S. L., Cho, S. L., Stuber, G. D., Messing, R. O., Ron, D. & Bonci, A., Oct 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 10, p. 1680-1687 8 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone Receptors
Binge Drinking
Ventral Tegmental Area
Corticotropin-Releasing Hormone
Ethanol
117 Citations (Scopus)

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

Seif, T., Chang, S. J., Simms, J. A., Gibb, S. L., Dadgar, J., Chen, B. T., Harvey, B. K., Ron, D., Messing, R. O., Bonci, A. & Hopf, F. W., Aug 1 2013, In : Nature Neuroscience. 16, 8, p. 1094-1100 7 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
N-Methyl-D-Aspartate Receptors
Alcohols
Medical Economics
Glutamate Receptors
153 Citations (Scopus)

Prkcz null mice show normal learning and memory

Lee, A. M., Kanter, B. R., Wang, D., Lim, J. P., Zou, M. E., Qiu, C., McMahon, T., Dadgar, J., Fischbach-Weiss, S. C. & Messing, R. O., Jan 17 2013, In : NATURE. 493, 7432, p. 416-419 4 p.

Research output: Contribution to journalArticle

Protein Kinase C
Learning
Peptides
Cocaine
Long-Term Memory
11 Citations (Scopus)

Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs

Schuster, D. J., Kitto, K. F., Overland, A. C., Messing, R. O., Stone, L. S., Fairbanks, C. A. & Wilcox, G. L., Aug 20 2013, In : Journal of Neuroscience. 33, 33, p. 13538-13546 9 p.

Research output: Contribution to journalArticle

Adrenergic alpha-2 Receptors
Adrenergic alpha-Agonists
Protein Kinase C
Opioid Analgesics
Analgesics
17 Citations (Scopus)

SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans

Jee, C., Lee, J., Lim, J. P., Parry, D., Messing, R. O. & Mcintire, S. L., Mar 1 2013, In : Genes, Brain and Behavior. 12, 2, p. 250-262 13 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone Receptors
Caenorhabditis elegans
Locomotion
Corticotropin-Releasing Hormone
Ethanol
2012
22 Citations (Scopus)

PKCε phosphorylation of the sodium channel Na V1.8 increases channel function and produces mechanical hyperalgesia in mice

Wu, D. F., Chandra, D., McMahon, T., Wang, D., Dadgar, J., Kharazia, V. N., Liang, Y. J., Waxman, S. G., Dib-Hajj, S. D. & Messing, R. O., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Hyperalgesia
Phosphorylation
Nociceptors
S 145
11 Citations (Scopus)

Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice

Lim, J. P., Zou, M. E., Janak, P. H. & Messing, R. O., Jan 1 2012, In : Brain and Behavior. 2, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

129 Strain Mouse
Ethanol
Inbred C57BL Mouse
Drinking
Righting Reflex
12 Citations (Scopus)

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein Kinase Cδ *

Shanmugasundararaj, S., Das, J., Sandberg, W. S., Zhou, X., Wang, D., Messing, R. O., Bruzik, K. S., Stehle, T. & Miller, K. W., Dec 5 2012, In : Biophysical Journal. 103, 11, p. 2331-2340 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Cysteine
Anesthetics
Binding Sites
Hydrogen
12 Citations (Scopus)

The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers

Mitchell, J. M., Grossman, L. E., Coker, A. R. & Messing, R. O., Apr 1 2012, In : Journal of Clinical Psychopharmacology. 32, 2, p. 269-272 4 p.

Research output: Contribution to journalArticle

etiracetam
Alcohol Drinking
Anticonvulsants
Alcohols
Drinking
2011
2 Citations (Scopus)

How should addiction-related research at the national institutes of health be reorganized?

Johnson, B. A., Messing, R. O., Charness, M. E., Crabbe, J. C., Goldman, M. S., Harris, R. A., Kranzler, H. R., Mitchell, M. C., Nixon, S. J., Riley, E. P., Schuckit, M. A., Sher, K. J. & Thomas, J. D., Dec 1 2011, In : Frontiers in Psychiatry. 2, MAY, Article 2.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Research
76 Citations (Scopus)

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

Pabla, N., Dong, G., Jiang, M., Huang, S., Kumar, M. V., Messing, R. O. & Dong, Z., Jul 1 2011, In : Journal of Clinical Investigation. 121, 7, p. 2709-2722 14 p.

Research output: Contribution to journalArticle

Cisplatin
Neoplasms
Kidney
Drug Therapy
Apoptosis

Mouse model of middle cerebral artery occlusion.

Chiang, T., Messing, R. O. & Chou, W. H., Dec 1 2011, In : Journal of visualized experiments : JoVE. 48

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Brain
Stroke
Middle Cerebral Artery
Blood vessels
16 Citations (Scopus)
Protein Kinase C-epsilon
Nucleus Accumbens
Nicotine
Reward
Dopamine
1 Citation (Scopus)

Should the Reorganization of Addiction-Related Research Across All the National Institutes of Health Be Structural?-The Devil Is Truly in the Details

Johnson, B. A., Messing, R. O., Charness, M. E., Crabbe, J. C., Goldman, M. S., Harris, R. A., Kranzler, H. R., Mitchell, M. C., Nixon, S. J., Riley, E. P., Schuckit, M. A., Sher, K. J. & Thomas, J. D., Apr 1 2011, In : Alcoholism: Clinical and Experimental Research. 35, 4, p. 572-580 9 p.

Research output: Contribution to journalArticle

National Institutes of Health (U.S.)
Alcohols
Health
Tobacco
Substance-Related Disorders
58 Citations (Scopus)

Signaling pathways mediating alcohol effects

Ron, D. & Messing, R. O., Aug 30 2011, In : Current Topics in Behavioral Neurosciences. 13, p. 87-126 40 p.

Research output: Contribution to journalArticle

Ethanol
Alcohols
Histone Code
Addictive Behavior
Gene Expression
2010
38 Citations (Scopus)

GABAA receptor trafficking is regulated by protein kinase Cε and the N-ethylmaleimide-sensitive factor

Chou, W. H., Wang, D., McMahon, T., Qi, Z. H., Song, M., Zhang, C., Shokat, K. M. & Messing, R. O., Oct 20 2010, In : Journal of Neuroscience. 30, 42, p. 13955-13965 11 p.

Research output: Contribution to journalArticle

N-Ethylmaleimide-Sensitive Proteins
GABA-A Receptors
Protein Kinase C
Down-Regulation
protein kinase N
29 Citations (Scopus)

Mouse model of middle cerebral artery occlusion

Chiang, T., Messing, R. O. & Chou, W. H., Jan 1 2010, In : Journal of Visualized Experiments. 48, e2761.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Brain
Stroke
Middle Cerebral Artery
Blood vessels
44 Citations (Scopus)

PKC-δ promotes renal tubular cell apoptosis associated with proteinuria

Li, X., Pabla, N., Wei, Q., Dong, G., Messing, R. O., Wang, C. Y. & Dong, Z., Jul 1 2010, In : Journal of the American Society of Nephrology. 21, 7, p. 1115-1124 10 p.

Research output: Contribution to journalArticle

Proteinuria
Albumins
Apoptosis
Kidney
Albuminuria
2009
39 Citations (Scopus)

Amygdala protein kinase C epsilon controls alcohol consumption

Lesscher, H. M. B., Wallace, M. J., Zeng, L., Wang, V., Deitchman, J. K., McMahon, T., Messing, R. O. & Newton, P. M., Jul 1 2009, In : Genes, Brain and Behavior. 8, 5, p. 493-499 7 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Amygdala
Alcohol Drinking
Ethanol
Reward
11 Citations (Scopus)

PKC regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2

Wallace, M. J., Newton, P. M., McMahon, T., Connolly, J., Huibers, A., Whistler, J. & Messing, R. O., Jun 1 2009, In : Neuropsychopharmacology. 34, 7, p. 1733-1742 10 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Protein Kinase C
rimonabant
Protein Kinase C-epsilon
Brain
9 Citations (Scopus)

The N-type calcium channel is a novel target for treating alcohol use disorders

Newton, P. M. & Messing, R. O., Jan 1 2009, In : Channels. 3, 2, p. 77-81 5 p.

Research output: Contribution to journalArticle

N-Type Calcium Channels
Alcohols
Ethanol
T-Type Calcium Channels
Calcium Channel Blockers
43 Citations (Scopus)

The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or ent1(-/-) mouse erythrocytes

Endres, C. J., Moss, A. M., Ke, B., Govindarajan, R., Choi, D. S., Messing, R. O. & Unadkat, J. D., Apr 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 1, p. 387-398 12 p.

Research output: Contribution to journalArticle

Equilibrative Nucleoside Transporter 1
Ribavirin
Erythrocytes
2008
31 Citations (Scopus)

A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement

Newton, P. M., Zeng, L., Wang, V., Connolly, J., Wallace, M. J., Kim, C., Shin, H. S., Belardetti, F., Snutch, T. P. & Messing, R. O., Nov 5 2008, In : Journal of Neuroscience. 28, 45, p. 11712-11719 8 p.

Research output: Contribution to journalArticle

Self Administration
Calcium Channels
Ethanol
T-Type Calcium Channels
N-Type Calcium Channels
30 Citations (Scopus)

Alcohol-induced stress in painful alcoholic neuropathy

Dina, O. A., Khasar, S. G., Alessandri-Haber, N., Green, P. G., Messing, R. O. & Levine, J. D., Jan 1 2008, In : European Journal of Neuroscience. 27, 1, p. 83-92 10 p.

Research output: Contribution to journalArticle

Alcoholic Neuropathy
Alcohol Drinking
Mifepristone
Glucocorticoid Receptors
Alcohols
31 Citations (Scopus)

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior

Lesscher, H. M. B., McMahon, T., Lasek, A. W., Chou, W. H., Connolly, J., Kharazia, V. & Messing, R. O., Apr 1 2008, In : Genes, Brain and Behavior. 7, 3, p. 323-333 11 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
Corticotropin-Releasing Hormone
Amygdala
Anxiety
RNA Interference
22 Citations (Scopus)

Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy

Dina, O. A., Khasar, S. G., Alessandri-Haber, N., Bogen, O., Chen, X., Green, P. G., Reichling, D. B., Messing, R. O. & Levine, J. D., Sep 1 2008, In : European Journal of Neuroscience. 28, 6, p. 1180-1190 11 p.

Research output: Contribution to journalArticle

Nociceptors
Peripheral Nervous System Diseases
Monoamine Oxidase
Catecholamines
Sensory Receptor Cells
86 Citations (Scopus)

Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala

Bajo, M., Cruz, M. T., Siggins, G. R., Messing, R. O. & Roberto, M., Jun 17 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8410-8415 6 p.

Research output: Contribution to journalArticle

Protein Kinase C-epsilon
gamma-Aminobutyric Acid
Ethanol
Anxiety
Alcohol Drinking
63 Citations (Scopus)

Protein kinase Cδ regulates ethanol intoxication and enhancement of GABA-stimulated tonic current

Choi, D. S., Wei, W., Deitchman, J. K., Kharazia, V. N., Lesscher, H. M. B., McMahon, T., Wang, D., Qi, Z. H., Sieghart, W., Zhang, C., Shokat, K. M., Mody, I. & Messing, R. O., Nov 12 2008, In : Journal of Neuroscience. 28, 46, p. 11890-11899 10 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Protein Kinase C
Ethanol
GABA-A Receptors
Pregnanolone
28 Citations (Scopus)

The identification and characterization of novel PKCε phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily

Durgan, J., Cameron, A. J., Saurin, A. T., Hanrahan, S., Totty, N., Messing, R. O. & Parker, P. J., Apr 15 2008, In : Biochemical Journal. 411, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinase C
Protein Isoforms
Protein-Serine-Threonine Kinases
Scaffolds
2007
39 Citations (Scopus)

Acute functional tolerance to ethanol mediated by protein kinase Cε

Wallace, M. J., Newton, P. M., Oyasu, M., McMahon, T., Chou, W. H., Connolly, J. & Messing, R. O., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Ethanol
Protein Kinase C-epsilon
GABA-A Receptors
Drinking
168 Citations (Scopus)

A semisynthetic epitope for kinase substrates

Allen, J. J., Li, M., Brinkworth, C. S., Paulson, J. L., Wang, D., Hübner, A., Chou, W. H., Davis, R. J., Burlingame, A. L., Messing, R. O., Katayama, C. D., Hedrick, S. M. & Shokat, K. M., Jun 1 2007, In : Nature Methods. 4, 6, p. 511-516 6 p.

Research output: Contribution to journalArticle

Epitopes
Phosphotransferases
Substrates
Mitogen-Activated Protein Kinase 8
Phosphorylation
31 Citations (Scopus)

Increased response to morphine in mice lacking protein kinase C epsilon

Newton, P. M., Kim, J. A., McGeehan, A. J., Paredes, J. P., Chu, K., Wallace, M. J., Roberts, A. J., Hodge, C. W. & Messing, R. O., Jun 1 2007, In : Genes, Brain and Behavior. 6, 4, p. 329-338 10 p.

Research output: Contribution to journalArticle

Morphine
Protein Kinase C
Opiate Alkaloids
Self Administration
Analgesics
20 Citations (Scopus)

Increased Sensitivity to the Aversive Effects of Ethanol in PKCε{lunate} Null Mice Revealed by Place Conditioning

Newton, P. M. & Messing, R. O., Apr 1 2007, In : Behavioral neuroscience. 121, 2, p. 439-442 4 p.

Research output: Contribution to journalArticle

Ethanol
Protein Kinase C-epsilon
Self Administration
Conditioning (Psychology)
Reward