3D cell-laden polymers to release bioactive products in the eye

Gorka Orive, Edorta Santos-Vizcaino, Jose Luis Pedraz, Rosa Maria Hernandez, Julia E. Vela Ramirez, Alireza Dolatshahi-Pirouz, Ali Khademhosseini, Nicholas Peppas, Dwaine F. Emerich

Research output: Contribution to journalReview article

Abstract

Millions of people worldwide suffer from debilitating, progressive, and often permanent loss of vision without any viable treatment options. The complex physiological barriers of the eye contribute to the difficulty in developing novel therapies by limiting our ability to deliver therapeutics in a sustained and controlled manner; especially when attempting to deliver drugs to the posterior eye or trying to regenerate the diseased retina. Cell-based therapies offer a significant potential advancement in these situations. In particular, encapsulating, or immunoisolating, cells within implantable, semi-permeable membranes has emerged as a clinically viable means of delivering therapeutic molecules to the eye for indefinite periods of time. The optimization of encapsulation device designs is occurring together with refinements in biomaterials, genetic engineering, and stem-cell production, yielding, for the first time, the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored iteration of cell encapsulation with an eye toward translating the potential of this technological approach to the medical reality.

Original languageEnglish (US)
Pages (from-to)67-82
Number of pages16
JournalProgress in Retinal and Eye Research
Volume68
DOIs
StatePublished - Jan 1 2019

Fingerprint

Polymers
Equipment Design
Aptitude
Genetic Engineering
Biocompatible Materials
Therapeutic Uses
Therapeutics
Cell- and Tissue-Based Therapy
Retina
Stem Cells
Technology
Membranes
Pharmaceutical Preparations

Keywords

  • Cell therapy
  • Drug delivery
  • Encapsulated cell technology
  • Encapsulation
  • Ophthalmic diseases
  • Protein

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Orive, G., Santos-Vizcaino, E., Pedraz, J. L., Hernandez, R. M., Vela Ramirez, J. E., Dolatshahi-Pirouz, A., ... Emerich, D. F. (2019). 3D cell-laden polymers to release bioactive products in the eye. Progress in Retinal and Eye Research, 68, 67-82. https://doi.org/10.1016/j.preteyeres.2018.10.002

3D cell-laden polymers to release bioactive products in the eye. / Orive, Gorka; Santos-Vizcaino, Edorta; Pedraz, Jose Luis; Hernandez, Rosa Maria; Vela Ramirez, Julia E.; Dolatshahi-Pirouz, Alireza; Khademhosseini, Ali; Peppas, Nicholas; Emerich, Dwaine F.

In: Progress in Retinal and Eye Research, Vol. 68, 01.01.2019, p. 67-82.

Research output: Contribution to journalReview article

Orive, G, Santos-Vizcaino, E, Pedraz, JL, Hernandez, RM, Vela Ramirez, JE, Dolatshahi-Pirouz, A, Khademhosseini, A, Peppas, N & Emerich, DF 2019, '3D cell-laden polymers to release bioactive products in the eye', Progress in Retinal and Eye Research, vol. 68, pp. 67-82. https://doi.org/10.1016/j.preteyeres.2018.10.002
Orive G, Santos-Vizcaino E, Pedraz JL, Hernandez RM, Vela Ramirez JE, Dolatshahi-Pirouz A et al. 3D cell-laden polymers to release bioactive products in the eye. Progress in Retinal and Eye Research. 2019 Jan 1;68:67-82. https://doi.org/10.1016/j.preteyeres.2018.10.002
Orive, Gorka ; Santos-Vizcaino, Edorta ; Pedraz, Jose Luis ; Hernandez, Rosa Maria ; Vela Ramirez, Julia E. ; Dolatshahi-Pirouz, Alireza ; Khademhosseini, Ali ; Peppas, Nicholas ; Emerich, Dwaine F. / 3D cell-laden polymers to release bioactive products in the eye. In: Progress in Retinal and Eye Research. 2019 ; Vol. 68. pp. 67-82.
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