A Case of Murine Typhus Presenting with Hemophagocytic Lymphohistiocytosis

Samuel Poulos, Brain Grundy, Mohammed Al Mouslmani, Sunil Bellur, Boone Goodgame, Eizabeth Douglass, Kristin Mondy

Research output: Contribution to journalArticle

Abstract

Murine typhus, also known as endemic typhus, is a rickettsial illness transmitted by the flea Xenopsylla cheopis, usually in contact with rats. Symptoms of the illness can be nonspecific, and murine typhus has been considered an underrecognized entity as it is sometimes confused with viral illnesses. Although hemophagocytic lymphohistiocytosis (HLH), a rare inflammatory condition characterized by activation of macrophages and phagocytosis of hematopoietic cells in the bone marrow, liver, and spleen, has been reported to occur in other rickettsial illnesses, to our knowledge it has not been reported as a complication of murine typhus. We report the case of a 39-year-old man for whom murine typhus was diagnosed with serological evaluation and HLH was diagnosed via bone marrow biopsy and other studies. Although HLH has been previously described with scrub typhus, and iron overload has been described with murine typhus infection, our case represents the first report of HLH diagnosed concurrently with a murine typhus infection.

Original languageEnglish (US)
Pages (from-to)298-300
Number of pages3
JournalInfectious Diseases in Clinical Practice
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2019

Fingerprint

Endemic Flea-Borne Typhus
Hemophagocytic Lymphohistiocytosis
Xenopsylla
Scrub Typhus
Siphonaptera
Iron Overload
Macrophage Activation
Infection
Phagocytosis
Bone Marrow Cells
Spleen
Bone Marrow
Biopsy
Liver

Keywords

  • HLH
  • endemic typhus
  • hemophagocytic lymphohistiocytosis
  • murine typhus
  • tick-borne illness
  • typhus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

A Case of Murine Typhus Presenting with Hemophagocytic Lymphohistiocytosis. / Poulos, Samuel; Grundy, Brain; Al Mouslmani, Mohammed; Bellur, Sunil; Goodgame, Boone; Douglass, Eizabeth; Mondy, Kristin.

In: Infectious Diseases in Clinical Practice, Vol. 27, No. 5, 01.09.2019, p. 298-300.

Research output: Contribution to journalArticle

Poulos, Samuel ; Grundy, Brain ; Al Mouslmani, Mohammed ; Bellur, Sunil ; Goodgame, Boone ; Douglass, Eizabeth ; Mondy, Kristin. / A Case of Murine Typhus Presenting with Hemophagocytic Lymphohistiocytosis. In: Infectious Diseases in Clinical Practice. 2019 ; Vol. 27, No. 5. pp. 298-300.
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