A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems

Jared A. Weisa, Thomas E. Yankeelov, Samantha A. Munoz, Rahul A. Sastry, Stephanie L. Barnes, Lori R. Arlinghaus, Xia Li, Michael I. Miga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Unlike many other experimental imaging methods, elastography has enjoyed a strong link to the standard diagnostic and interventional evaluation technique of soft tissue palpation. As a result, the initial excitement about elastography quickly translated to clinical use (e.g., [1-3]) which now includes commercially available ultrasound and magnetic resonance (MR) elastography products. However, despite these advances, understanding what these macroscopic clinical-scale tissue measurements indicate with respect to the underlying cellular and tissue-matrix scale phenomena is largely unclear. In this work, we present preliminary data towards a more systematic study of the elasticity biomarker in characterizing cancer for therapeutic design and monitoring. In addition, we demonstrate that we can conduct these studies with techniques that are consistent across both pre-clinical (i.e., mouse) and clinical length scales. The elastography method we use is called modality independent elastography (MIE) [4, 5] and can be described as a highly translatable model-based inverse image-analysis method that reconstructs elasticity images using two acquired image volumes in a pre-post state of deformation. Quantitative phantom results using independent testing methods report an elastic property contrast between the inclusion and background as a 14.9 to 1 stiffness ratio with MIE reconstructing the ratio as 13.1 to 1. Preliminary elasticity reconstructions in murine and human systems are reported and are consistent with literature findings.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2013
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
StatePublished - Jun 3 2013
EventMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 10 2013Feb 13 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8672
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/10/132/13/13

Fingerprint

Elasticity Imaging Techniques
Tumors
Elasticity
tumors
elastic properties
mechanical properties
Tissue
Mechanical properties
Neoplasms
Biomarkers
Magnetic resonance
Image analysis
biomarkers
Therapeutics
Ultrasonics
image analysis
Stiffness
mice
magnetic resonance
Imaging techniques

Keywords

  • Breast cancer
  • Elastography
  • Mechanical model
  • Mechanical properties
  • Parameter reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Weisa, J. A., Yankeelov, T. E., Munoz, S. A., Sastry, R. A., Barnes, S. L., Arlinghaus, L. R., ... Miga, M. I. (2013). A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems. In Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging [86721F] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8672). https://doi.org/10.1117/12.2007425

A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems. / Weisa, Jared A.; Yankeelov, Thomas E.; Munoz, Samantha A.; Sastry, Rahul A.; Barnes, Stephanie L.; Arlinghaus, Lori R.; Li, Xia; Miga, Michael I.

Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2013. 86721F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8672).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Weisa, JA, Yankeelov, TE, Munoz, SA, Sastry, RA, Barnes, SL, Arlinghaus, LR, Li, X & Miga, MI 2013, A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems. in Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging., 86721F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/10/13. https://doi.org/10.1117/12.2007425
Weisa JA, Yankeelov TE, Munoz SA, Sastry RA, Barnes SL, Arlinghaus LR et al. A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems. In Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2013. 86721F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2007425
Weisa, Jared A. ; Yankeelov, Thomas E. ; Munoz, Samantha A. ; Sastry, Rahul A. ; Barnes, Stephanie L. ; Arlinghaus, Lori R. ; Li, Xia ; Miga, Michael I. / A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems. Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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