A Contemporary Look at Biomechanical Models of Myocardium

Reza Avazmohammadi, João S. Soares, David S. Li, Samarth S. Raut, Robert C. Gorman, Michael S Sacks

Research output: Contribution to journalReview article

Abstract

Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural observations, and specific test conditions to which they are fitted. We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium. We further explore the experimental and numerical techniques used to identify the model parameters. Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior. We conclude by pointing to future directions in the areas of optimal form as well as new approaches for constitutive modeling of myocardium.

Original languageEnglish (US)
Pages (from-to)417-442
Number of pages26
JournalAnnual Review of Biomedical Engineering
Volume21
DOIs
StatePublished - Jan 1 2019

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Myocardium
Constitutive models
Therapeutics

Keywords

  • constitutive behavior
  • electromechanics
  • growth and remodeling
  • myocardial tissue
  • structural models

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

A Contemporary Look at Biomechanical Models of Myocardium. / Avazmohammadi, Reza; Soares, João S.; Li, David S.; Raut, Samarth S.; Gorman, Robert C.; Sacks, Michael S.

In: Annual Review of Biomedical Engineering, Vol. 21, 01.01.2019, p. 417-442.

Research output: Contribution to journalReview article

Avazmohammadi, Reza ; Soares, João S. ; Li, David S. ; Raut, Samarth S. ; Gorman, Robert C. ; Sacks, Michael S. / A Contemporary Look at Biomechanical Models of Myocardium. In: Annual Review of Biomedical Engineering. 2019 ; Vol. 21. pp. 417-442.
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