A corticotropin releasing factor network in the extended amygdala for anxiety

Matthew B. Pomrenze, Jorge Tovar-Diaz, Angelo Blasio, Rajani Maiya, Simone M. Giovanetti, Kelly Lei, Hitoshi Morikawa, F. Woodward Hopf, Robert O Messing

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings indicate that the CeA also contributes to states of sustained apprehension that characterize anxiety, although little is known about the neural circuitry involved. The stress neuropeptide corticotropin releasing factor (CRF) is anxiogenic and is produced by subpopulations of neurons in the lateral CeA and the dorsolateral bed nucleus of the stria terminalis (dlBST). Here we investigated the function of these CRF neurons in stress-induced anxiety using chemogenetics in male rats that express Cre recombinase from a Crh promoter. Anxiety-like behavior was mediated by CRF projections from the CeA to the dlBST and depended on activation of CRF1 receptors and CRF neurons within the dlBST. Our findings identify a CRF CeA →CRF dlBST circuit for generating anxiety-like behavior and provide mechanistic support for recent human and primate data suggesting that the CeA and BST act together to generate states of anxiety.

Original languageEnglish (US)
Pages (from-to)1030-1043
Number of pages14
JournalJournal of Neuroscience
Volume39
Issue number6
DOIs
StatePublished - Feb 6 2019

Fingerprint

Corticotropin-Releasing Hormone
Amygdala
Septal Nuclei
Anxiety
Neurons
Neuropeptides
Primates
Fear
Cues
Central Amygdaloid Nucleus

Keywords

  • Amygdala
  • Anxiety
  • Bed nucleus of the stria terminals
  • Chemogenetics
  • Corticotropin releasing factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pomrenze, M. B., Tovar-Diaz, J., Blasio, A., Maiya, R., Giovanetti, S. M., Lei, K., ... Messing, R. O. (2019). A corticotropin releasing factor network in the extended amygdala for anxiety. Journal of Neuroscience, 39(6), 1030-1043. https://doi.org/10.1523/JNEUROSCI.2143-18.2018

A corticotropin releasing factor network in the extended amygdala for anxiety. / Pomrenze, Matthew B.; Tovar-Diaz, Jorge; Blasio, Angelo; Maiya, Rajani; Giovanetti, Simone M.; Lei, Kelly; Morikawa, Hitoshi; Woodward Hopf, F.; Messing, Robert O.

In: Journal of Neuroscience, Vol. 39, No. 6, 06.02.2019, p. 1030-1043.

Research output: Contribution to journalArticle

Pomrenze, MB, Tovar-Diaz, J, Blasio, A, Maiya, R, Giovanetti, SM, Lei, K, Morikawa, H, Woodward Hopf, F & Messing, RO 2019, 'A corticotropin releasing factor network in the extended amygdala for anxiety', Journal of Neuroscience, vol. 39, no. 6, pp. 1030-1043. https://doi.org/10.1523/JNEUROSCI.2143-18.2018
Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K et al. A corticotropin releasing factor network in the extended amygdala for anxiety. Journal of Neuroscience. 2019 Feb 6;39(6):1030-1043. https://doi.org/10.1523/JNEUROSCI.2143-18.2018
Pomrenze, Matthew B. ; Tovar-Diaz, Jorge ; Blasio, Angelo ; Maiya, Rajani ; Giovanetti, Simone M. ; Lei, Kelly ; Morikawa, Hitoshi ; Woodward Hopf, F. ; Messing, Robert O. / A corticotropin releasing factor network in the extended amygdala for anxiety. In: Journal of Neuroscience. 2019 ; Vol. 39, No. 6. pp. 1030-1043.
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