Bile Acids in Hepatic Encephalopathy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hepatic encephalopathy describes the array of neurological complications that arise due to liver insufficiency and/or portal-systemic shunt. The pathogenesis of hepatic encephalopathy shares a longstanding association with hyperammonemia and inflammation. Recently, aberrant bile acid signaling has been implicated in the development of key features of hepatic encephalopathy due to acute liver failure including neuronal dysfunction, neuroinflammation and blood–brain barrier permeability. This review summarizes the findings of recent studies demonstrating a role for bile acids in hepatic encephalopathy and speculates on the possible downstream consequences of bile acid signaling.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Clinical and Experimental Hepatology
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Hepatic Encephalopathy
Bile Acids and Salts
Hepatic Insufficiency
Hyperammonemia
Acute Liver Failure
Permeability
Inflammation

Keywords

  • blood–brain barrier
  • farnesoid X receptor
  • neuroinflammation
  • sphingosine-1-phosphate receptor 2
  • Takeda G-protein coupled receptor 5 (TGR5)

ASJC Scopus subject areas

  • Hepatology

Cite this

Bile Acids in Hepatic Encephalopathy. / DeMorrow, Sharon.

In: Journal of Clinical and Experimental Hepatology, Vol. 9, No. 1, 01.01.2019, p. 117-124.

Research output: Contribution to journalArticle

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