Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization

John R. Clegg, Jessie A. Sun, Eric W. Ander, Abhijeet Venkataraman, Nicholas Peppas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Currently, a very limited diversity of hydrophilic nanomaterials have been fabricated for drug delivery applications. Herein, we sought to increase the diversity and tunability of hydrophilic nanomaterials by designing an inverse emulsion polymerization schema with orthogonal modifications by bioconjugation. We generated 19 unique nanogel formulations by inverse emulsion polymerization, which differ in their pH-responsiveness due to differences in ionizable monomer identity and crosslinking. Two bioconjugation schema where employed to modify pendant acid groups with functional small molecules, fluorophores, and peptides. As proof-of-concept, we demonstrate the conservation of conjugated peptide activity, enhancement of nanomaterial uptake by tumor cells, and tunability of model drug partitioning via composition and environmental response.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Nanostructures
Emulsion polymerization
Emulsions
Nanostructured materials
Polymerization
Peptides
Fluorophores
Drug delivery
Pharmaceutical Preparations
Crosslinking
Tumors
Conservation
Monomers
Cells
Molecules
Acids
Chemical analysis
NanoGel
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Clegg, J. R., Sun, J. A., Ander, E. W., Venkataraman, A., & Peppas, N. (2019). Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization. / Clegg, John R.; Sun, Jessie A.; Ander, Eric W.; Venkataraman, Abhijeet; Peppas, Nicholas.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Clegg, JR, Sun, JA, Ander, EW, Venkataraman, A & Peppas, N 2019, Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Clegg JR, Sun JA, Ander EW, Venkataraman A, Peppas N. Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Clegg, John R. ; Sun, Jessie A. ; Ander, Eric W. ; Venkataraman, Abhijeet ; Peppas, Nicholas. / Biological characterization of intelligent nanogels synthesized by inverse emulsion polymerization. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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