Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein

A clinicopathologic study of 26 cases

C. Cameron Yin, Pei Lin, Dennis A. Carney, Beverly C. Handy, George Z. Rassidakis, Joan Admirand, Michael J. Keating, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We studied the clinicopathologic, immunophenotypic, and cytogenetic features of 26 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with serum IgM paraprotein. The study group (16 men; 10 women; median age, 64 years; range, 40-82 years) represents approximately 2.5% of CLL/SLL cases at our institution. The paraprotein level ranged from 1 to 14 g/L (median, 4 g/L). Neoplasms in bone marrow were composed of small round lymphocytes arranged in nodular (n = 6), diffuse (n = 5), interstitial (n = 5), or mixed (n = 10) patterns. All cases were positive for monotypic surface immunoglobulin light chain, IgM/IgD, CD5, CD19, CD20, and CD23. CD11c (14/20 [70%]), CD79b (11/19 [58%]), FMC-7 (11/26 [42%]), CD22 (8/20 [40%]), and ZAP-70 (6/19 [32%]) were expressed in subsets of cases. Of 17 bone marrow specimens assessed by conventional cytogenetics, 6 were abnormal and 11 were diploid. The overall survival of this group (median follow-up, 24 months) was not significantly different from that for an age-, sex-, and stage-matched group of 52 CLL/SLL patients without IgM paraprotein (P = .60). We conclude that CLL/SLL cases with serum IgM paraprotein are similar to other CLL/SLL cases in their clinicopathologic and immunophenotypic features.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume123
Issue number4
DOIs
StatePublished - Jan 1 2005

Fingerprint

Paraproteins
B-Cell Chronic Lymphocytic Leukemia
Immunoglobulin M
Cytogenetics
Bone Marrow Neoplasms
Immunoglobulin Light Chains
Immunoglobulin D
B-Cell Antigen Receptors
Serum
Diploidy
Research Design
Bone Marrow
Lymphocytes

Keywords

  • Chronic lymphocytic leukemia/small lymphocytic lymphoma
  • Plasmacytoid lymphocytes
  • Serum IgM
  • ZAP-70

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein : A clinicopathologic study of 26 cases. / Yin, C. Cameron; Lin, Pei; Carney, Dennis A.; Handy, Beverly C.; Rassidakis, George Z.; Admirand, Joan; Keating, Michael J.; Medeiros, L. Jeffrey.

In: American Journal of Clinical Pathology, Vol. 123, No. 4, 01.01.2005, p. 594-602.

Research output: Contribution to journalArticle

Yin, C. Cameron ; Lin, Pei ; Carney, Dennis A. ; Handy, Beverly C. ; Rassidakis, George Z. ; Admirand, Joan ; Keating, Michael J. ; Medeiros, L. Jeffrey. / Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein : A clinicopathologic study of 26 cases. In: American Journal of Clinical Pathology. 2005 ; Vol. 123, No. 4. pp. 594-602.
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