Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness

William Schwartz, Elizabeth B. Klerman

Research output: Contribution to journalReview article

Abstract

Endogenous central and peripheral circadian oscillators are key to organizing multiple aspects of mammalian physiology; this clock tracks the day-night cycle and governs behavioral and physiologic rhythmicity. Flexibility in the timing and duration of sleep and wakefulness, critical to the survival of species, is the result of a complex, dynamic interaction between 2 regulatory processes: the clock and a homeostatic drive that increases with wake duration and decreases during sleep. When circadian rhythmicity and sleep homeostasis are misaligned—as in shifted schedules, time zone transitions, aging, or disease—sleep, metabolic, and other disorders may ensue.

Original languageEnglish (US)
Pages (from-to)475-486
Number of pages12
JournalNeurologic Clinics
Volume37
Issue number3
DOIs
StatePublished - Aug 1 2019

Fingerprint

Neurobiology
Wakefulness
Sleep
Periodicity
Appointments and Schedules
Homeostasis

Keywords

  • Circadian rhythms
  • Homeostasis
  • Physiology
  • Sleep
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness. / Schwartz, William; Klerman, Elizabeth B.

In: Neurologic Clinics, Vol. 37, No. 3, 01.08.2019, p. 475-486.

Research output: Contribution to journalReview article

@article{fd1f4441583642b0b5d03f839c13f8d7,
title = "Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness",
abstract = "Endogenous central and peripheral circadian oscillators are key to organizing multiple aspects of mammalian physiology; this clock tracks the day-night cycle and governs behavioral and physiologic rhythmicity. Flexibility in the timing and duration of sleep and wakefulness, critical to the survival of species, is the result of a complex, dynamic interaction between 2 regulatory processes: the clock and a homeostatic drive that increases with wake duration and decreases during sleep. When circadian rhythmicity and sleep homeostasis are misaligned—as in shifted schedules, time zone transitions, aging, or disease—sleep, metabolic, and other disorders may ensue.",
keywords = "Circadian rhythms, Homeostasis, Physiology, Sleep, Suprachiasmatic nucleus",
author = "William Schwartz and Klerman, {Elizabeth B.}",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.ncl.2019.03.001",
language = "English (US)",
volume = "37",
pages = "475--486",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness

AU - Schwartz, William

AU - Klerman, Elizabeth B.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Endogenous central and peripheral circadian oscillators are key to organizing multiple aspects of mammalian physiology; this clock tracks the day-night cycle and governs behavioral and physiologic rhythmicity. Flexibility in the timing and duration of sleep and wakefulness, critical to the survival of species, is the result of a complex, dynamic interaction between 2 regulatory processes: the clock and a homeostatic drive that increases with wake duration and decreases during sleep. When circadian rhythmicity and sleep homeostasis are misaligned—as in shifted schedules, time zone transitions, aging, or disease—sleep, metabolic, and other disorders may ensue.

AB - Endogenous central and peripheral circadian oscillators are key to organizing multiple aspects of mammalian physiology; this clock tracks the day-night cycle and governs behavioral and physiologic rhythmicity. Flexibility in the timing and duration of sleep and wakefulness, critical to the survival of species, is the result of a complex, dynamic interaction between 2 regulatory processes: the clock and a homeostatic drive that increases with wake duration and decreases during sleep. When circadian rhythmicity and sleep homeostasis are misaligned—as in shifted schedules, time zone transitions, aging, or disease—sleep, metabolic, and other disorders may ensue.

KW - Circadian rhythms

KW - Homeostasis

KW - Physiology

KW - Sleep

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85065124322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065124322&partnerID=8YFLogxK

U2 - 10.1016/j.ncl.2019.03.001

DO - 10.1016/j.ncl.2019.03.001

M3 - Review article

C2 - 31256784

AN - SCOPUS:85065124322

VL - 37

SP - 475

EP - 486

JO - Neurologic Clinics

JF - Neurologic Clinics

SN - 0733-8619

IS - 3

ER -