Cognitive decline secondary to therapeutic brain radiation—similarities and differences to traumatic brain injury

Andrew Jonathan Huang, David Kornguth, Steven Kornguth

Research output: Contribution to journalArticle

Abstract

Traumatic brain injury (TBI) resulting from forceful impacts on the torso and head has been of major interest because of the prevalence of such injuries in military personnel, contact sports and the elderly. Cognitive and behavioral changes associated with TBI are also seen following whole brain radiation treatment for cancer and chemotherapy for disseminated tumors. The biological mechanisms involved in the initiation of TBI from impact, radiation, and chemotherapy to loss of cognitive function have several shared characteristics including increases in blood brain barrier permeability, blood vessel density, increases in inflammatory and autoimmune responses, alterations in NMDA and glutamate receptor levels and release of proteins normally sequestered in the brain into the blood and spinal fluid. The development of therapeutic agents that mitigate the loss of cognition and development of behavioral disorders in patients experiencing radiation-induced injury may provide benefit to those with TBI when similar processes are involved on a cellular or molecular level. Increased collaborative efforts between the radiation oncology and the neurology and psychiatry communities may be of major benefit for the management of brain injury from varied environmental insults.

Original languageEnglish (US)
Article number97
JournalBrain Sciences
Volume9
Issue number5
DOIs
StatePublished - May 2019

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Brain
Cognition
Radiation
Community Psychiatry
Drug Therapy
Torso
Radiation Injuries
Radiation Oncology
Military Personnel
Glutamate Receptors
Therapeutics
Neurology
N-Methyl-D-Aspartate Receptors
Blood-Brain Barrier
Autoimmunity
Brain Injuries
Sports
Blood Vessels
Permeability
Neoplasms

Keywords

  • Blood brain barrier
  • Cognitive loss
  • Immune factors
  • Inflammatory response
  • Radiation induced brain injury
  • Receptor changes
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cognitive decline secondary to therapeutic brain radiation—similarities and differences to traumatic brain injury. / Huang, Andrew Jonathan; Kornguth, David; Kornguth, Steven.

In: Brain Sciences, Vol. 9, No. 5, 97, 05.2019.

Research output: Contribution to journalArticle

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