Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer

Hohyeon Lee, Yongho Jang, Suhyun Park, Hyejin Jang, Eun Joo Park, Hyun Jung Kim, Hyuncheol Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metastasis is the leading cause of cancer-related deaths. A number of chemotherapeutic and early diagnosis strategies, including nanomedicine, have been developed to target metastatic tumor cells. However, simultaneous inhibition and imaging of metastasis is yet to be fully achieved. Methods: To overcome this limitation, we have developed human serum albumin-based nanoparticles (tHSA-NPs) with photoacoustic imaging capability, which target carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). CEACAM6 is highly expressed in metastatic anoikis-resistant tumor cells. Results: In vitro, the CEACAM6-targeting tHSA-NPs efficiently targeted CEACAM6-overexpressing metastatic anoikis-resistant tumor cells. In vivo, CEACAM6-targeting tHSA-NPs administered intravenously to BALB/c nude mice efficiently inhibited lung metastasis in circulating anoikis-resistant tumor cells compared to the controls. In addition, anoikis-resistant tumor cells can be successfully detected by photoacoustic imaging, both in vitro and in vivo, using the intrinsic indocyanine green-binding affinity of albumin. Conclusion: In summary, the CEACAM6-targeting albumin-based nanoparticles allowed the delivery of drugs and photoacoustic imaging to metastatic anoikis-resistant tumor cells in vitro and in vivo. Based on the expression of CEACAM6 in a variety of tumors, CEACAM6-targeting nanomedicine might be used to target various types of metastatic tumor cells.

Original languageEnglish (US)
Pages (from-to)4247-4261
Number of pages15
JournalTheranostics
Volume8
Issue number15
DOIs
StatePublished - Jan 1 2018

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Carcinoembryonic Antigen
Cell Adhesion Molecules
Anoikis
Drug Therapy
Neoplasms
Nanomedicine
Neoplasm Metastasis
Nanoparticles
Albumins
Indocyanine Green
Theranostic Nanomedicine
Neoplasm Antigens
Nude Mice
Serum Albumin
Early Diagnosis
Lung
Pharmaceutical Preparations

Keywords

  • Anoikis resistance
  • CEACAM6
  • Metastasis
  • Nanomedicine
  • Photoacoustic imaging

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer. / Lee, Hohyeon; Jang, Yongho; Park, Suhyun; Jang, Hyejin; Park, Eun Joo; Kim, Hyun Jung; Kim, Hyuncheol.

In: Theranostics, Vol. 8, No. 15, 01.01.2018, p. 4247-4261.

Research output: Contribution to journalArticle

Lee, Hohyeon ; Jang, Yongho ; Park, Suhyun ; Jang, Hyejin ; Park, Eun Joo ; Kim, Hyun Jung ; Kim, Hyuncheol. / Development and evaluation of a CEACAM6-targeting theranostic nanomedicine for photoacoustic-based diagnosis and chemotherapy of metastatic cancer. In: Theranostics. 2018 ; Vol. 8, No. 15. pp. 4247-4261.
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