Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness

Jared A. Weis, Allison M. Johnsen, Geoffrey E. Wile, Thomas Yankeelov, Richard G. Abramson, Michael I. Miga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Evaluation of mechanical stiffness imaging biomarkers, through magnetic resonance elastography (MRE), has shown considerable promise for non-invasive assessment of liver stiffness to monitor hepatic fibrosis. MRE typically requires specialized externally-applied vibratory excitation and scanner-specific motion-sensitive pulse sequences. In this work, we have developed an elasticity imaging approach that utilizes natural diaphragmatic respiratory motion to induce deformation and eliminates the need for external deformation excitation hardware and specialized pulse sequences. Our approach uses clinically-available standard of care volumetric imaging acquisitions, combined with offline model-based post-processing to generate volumetric estimates of stiffness within the liver and surrounding tissue structures. We have previously developed a novel methodology for non-invasive elasticity imaging which utilizes a model-based elasticity reconstruction algorithm and MR image volumes acquired under different states of deformation. In prior work, deformation was external applied through inflation of an air bladder placed within the MR radiofrequency coil. In this work, we extend the methodology with the goal of determining the feasibility of assessing liver mechanical stiffness using diaphragmatic respiratory motion between end-inspiration and end-expiration breath-holds as a source of deformation. We present initial investigations towards applying this methodology to assess liver stiffness in healthy volunteers and cirrhotic patients. Our preliminary results suggest that this method is capable of non-invasive image-based assessment of liver stiffness using natural diaphragmatic respiratory motion and provides considerable enthusiasm for extension of our approach towards monitoring liver stiffness in cirrhotic patients with limited impact to standard-of-care clinical imaging acquisition workflow.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Robert C. Molthen
PublisherSPIE
ISBN (Electronic)9781628415070
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9417
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

Fingerprint

Elasticity Imaging Techniques
liver
Liver
stiffness
Stiffness
Elasticity
Imaging techniques
elastic properties
methodology
Magnetic resonance
Standard of Care
magnetic resonance
acquisition
expiration
Air Sacs
inspiration
fibrosis
Workflow
bladder
biomarkers

Keywords

  • Elastography
  • Liver
  • Mechanical model
  • Mechanical properties
  • Parameter reconstruction

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Weis, J. A., Johnsen, A. M., Wile, G. E., Yankeelov, T., Abramson, R. G., & Miga, M. I. (2015). Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness. In B. Gimi, & R. C. Molthen (Eds.), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging [941703] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417). SPIE. https://doi.org/10.1117/12.2081257

Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness. / Weis, Jared A.; Johnsen, Allison M.; Wile, Geoffrey E.; Yankeelov, Thomas; Abramson, Richard G.; Miga, Michael I.

Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Robert C. Molthen. SPIE, 2015. 941703 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Weis, JA, Johnsen, AM, Wile, GE, Yankeelov, T, Abramson, RG & Miga, MI 2015, Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness. in B Gimi & RC Molthen (eds), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging., 941703, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9417, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/24/15. https://doi.org/10.1117/12.2081257
Weis JA, Johnsen AM, Wile GE, Yankeelov T, Abramson RG, Miga MI. Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness. In Gimi B, Molthen RC, editors, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2015. 941703. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2081257
Weis, Jared A. ; Johnsen, Allison M. ; Wile, Geoffrey E. ; Yankeelov, Thomas ; Abramson, Richard G. ; Miga, Michael I. / Development of a diaphragmatic motion-based elastography framework for assessment of liver stiffness. Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Robert C. Molthen. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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