Development of polymeric nanogels for tear biomarker detection

Marissa E. Wechsler, H. K.H. Jocelyn Dang, Susana P. Simmonds, Nicholas Peppas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Approximately 24 million people in the United States are currently living with at least one autoimmune disease. In the case of Sjögren's syndrome, lymphocytic infiltration of the exocrine glands (specifically salivary and lacrimal) are characteristic of this disease. Early diagnosis of Sjögren's syndrome remains a major clinical challenge largely due to signs and symptoms being invisible at the early stages. Patients with Sjögren's syndrome, are often unaware this disease may be present until they suffer from extreme dry mouth and eyes. However, before these symptoms present, changes at the molecular level are taking place before any major signs or symptoms are noticed. Diagnosing Sjögren's syndrome in the early stages of the disease could reduce the risk of vision loss or other life-threatening complications, yet it is often delayed by up to 10 years. Thus, there is a strong need to develop novel biosensor recognition agents to detect changes in disease specific protein biomarker expression for screening and diagnostic applications. For this purpose, polymeric nanogels were synthesized for detection of biomarkers indicative of dry eye, a major symptom of Sjögren's syndrome.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Biomarkers
Tears
Signs and Symptoms
Exocrine Glands
Biosensing Techniques
Infiltration
Biosensors
Autoimmune Diseases
Mouth
Early Diagnosis
Screening
NanoGel
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Wechsler, M. E., Jocelyn Dang, H. K. H., Simmonds, S. P., & Peppas, N. (2019). Development of polymeric nanogels for tear biomarker detection. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Development of polymeric nanogels for tear biomarker detection. / Wechsler, Marissa E.; Jocelyn Dang, H. K.H.; Simmonds, Susana P.; Peppas, Nicholas.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wechsler, ME, Jocelyn Dang, HKH, Simmonds, SP & Peppas, N 2019, Development of polymeric nanogels for tear biomarker detection. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Wechsler ME, Jocelyn Dang HKH, Simmonds SP, Peppas N. Development of polymeric nanogels for tear biomarker detection. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Wechsler, Marissa E. ; Jocelyn Dang, H. K.H. ; Simmonds, Susana P. ; Peppas, Nicholas. / Development of polymeric nanogels for tear biomarker detection. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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