Diabetes negatively impacts the ten-year survival rates of people living with HIV

Jungmin Park, Julie A. Zuñiga, Alexandra A. García

Research output: Contribution to journalArticle

Abstract

People living with HIV (PLWH) are dying of non-AIDS associated conditions, including type 2 diabetes and chronic kidney disease (CKD), but the impact of diabetes and CKD on HIV survival rates is unknown. The purpose of this retrospective longitudinal study was to investigate the impact of diabetes and CKD on the survival rates of PLWH, using a secondary analysis of data from the Centers for AIDS Research Network of Integrated Clinical Systems (N = 10,043 PLWH). The sample was divided into three comorbidity groups: HIV alone, HIV with diabetes, and HIV with diabetes and CKD. Kaplan–Meier analysis was used to examine survival rates; Cox regression was used to assess relationships between variables. Overall mean survival time was 19.7 years (95% CI, 19.57–19.8). For HIV alone (n = 8266), the mortality rate was 3.6%; for HIV with diabetes (n = 1720), mortality was almost three times higher (12.0%); and for HIV with diabetes and CKD (n = 57), survival was less than three times higher (36.8%) than for HIV alone. Knowing that diabetes mellitus decreases survival rates, healthcare providers need to halt or delay the onset of type 2 diabetes by more aggressively assessing for prediabetes and treating it.

Original languageEnglish (US)
Pages (from-to)991-998
Number of pages8
JournalInternational Journal of STD and AIDS
Volume30
Issue number10
DOIs
StatePublished - Sep 1 2019

Fingerprint

Survival Rate
HIV
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Prediabetic State
Mortality
Health Personnel
Longitudinal Studies
Comorbidity
Diabetes Mellitus
Acquired Immunodeficiency Syndrome
Retrospective Studies
Research

Keywords

  • Antiretroviral therapy
  • HIV
  • chronic kidney disease
  • comorbid conditions
  • diabetes
  • survival rates

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Diabetes negatively impacts the ten-year survival rates of people living with HIV. / Park, Jungmin; Zuñiga, Julie A.; García, Alexandra A.

In: International Journal of STD and AIDS, Vol. 30, No. 10, 01.09.2019, p. 991-998.

Research output: Contribution to journalArticle

@article{e3a8d787219f4334b44f4d5a08065f4f,
title = "Diabetes negatively impacts the ten-year survival rates of people living with HIV",
abstract = "People living with HIV (PLWH) are dying of non-AIDS associated conditions, including type 2 diabetes and chronic kidney disease (CKD), but the impact of diabetes and CKD on HIV survival rates is unknown. The purpose of this retrospective longitudinal study was to investigate the impact of diabetes and CKD on the survival rates of PLWH, using a secondary analysis of data from the Centers for AIDS Research Network of Integrated Clinical Systems (N = 10,043 PLWH). The sample was divided into three comorbidity groups: HIV alone, HIV with diabetes, and HIV with diabetes and CKD. Kaplan–Meier analysis was used to examine survival rates; Cox regression was used to assess relationships between variables. Overall mean survival time was 19.7 years (95{\%} CI, 19.57–19.8). For HIV alone (n = 8266), the mortality rate was 3.6{\%}; for HIV with diabetes (n = 1720), mortality was almost three times higher (12.0{\%}); and for HIV with diabetes and CKD (n = 57), survival was less than three times higher (36.8{\%}) than for HIV alone. Knowing that diabetes mellitus decreases survival rates, healthcare providers need to halt or delay the onset of type 2 diabetes by more aggressively assessing for prediabetes and treating it.",
keywords = "Antiretroviral therapy, HIV, chronic kidney disease, comorbid conditions, diabetes, survival rates",
author = "Jungmin Park and Zu{\~n}iga, {Julie A.} and Garc{\'i}a, {Alexandra A.}",
year = "2019",
month = "9",
day = "1",
doi = "10.1177/0956462419857005",
language = "English (US)",
volume = "30",
pages = "991--998",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "10",

}

TY - JOUR

T1 - Diabetes negatively impacts the ten-year survival rates of people living with HIV

AU - Park, Jungmin

AU - Zuñiga, Julie A.

AU - García, Alexandra A.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - People living with HIV (PLWH) are dying of non-AIDS associated conditions, including type 2 diabetes and chronic kidney disease (CKD), but the impact of diabetes and CKD on HIV survival rates is unknown. The purpose of this retrospective longitudinal study was to investigate the impact of diabetes and CKD on the survival rates of PLWH, using a secondary analysis of data from the Centers for AIDS Research Network of Integrated Clinical Systems (N = 10,043 PLWH). The sample was divided into three comorbidity groups: HIV alone, HIV with diabetes, and HIV with diabetes and CKD. Kaplan–Meier analysis was used to examine survival rates; Cox regression was used to assess relationships between variables. Overall mean survival time was 19.7 years (95% CI, 19.57–19.8). For HIV alone (n = 8266), the mortality rate was 3.6%; for HIV with diabetes (n = 1720), mortality was almost three times higher (12.0%); and for HIV with diabetes and CKD (n = 57), survival was less than three times higher (36.8%) than for HIV alone. Knowing that diabetes mellitus decreases survival rates, healthcare providers need to halt or delay the onset of type 2 diabetes by more aggressively assessing for prediabetes and treating it.

AB - People living with HIV (PLWH) are dying of non-AIDS associated conditions, including type 2 diabetes and chronic kidney disease (CKD), but the impact of diabetes and CKD on HIV survival rates is unknown. The purpose of this retrospective longitudinal study was to investigate the impact of diabetes and CKD on the survival rates of PLWH, using a secondary analysis of data from the Centers for AIDS Research Network of Integrated Clinical Systems (N = 10,043 PLWH). The sample was divided into three comorbidity groups: HIV alone, HIV with diabetes, and HIV with diabetes and CKD. Kaplan–Meier analysis was used to examine survival rates; Cox regression was used to assess relationships between variables. Overall mean survival time was 19.7 years (95% CI, 19.57–19.8). For HIV alone (n = 8266), the mortality rate was 3.6%; for HIV with diabetes (n = 1720), mortality was almost three times higher (12.0%); and for HIV with diabetes and CKD (n = 57), survival was less than three times higher (36.8%) than for HIV alone. Knowing that diabetes mellitus decreases survival rates, healthcare providers need to halt or delay the onset of type 2 diabetes by more aggressively assessing for prediabetes and treating it.

KW - Antiretroviral therapy

KW - HIV

KW - chronic kidney disease

KW - comorbid conditions

KW - diabetes

KW - survival rates

UR - http://www.scopus.com/inward/record.url?scp=85070409490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070409490&partnerID=8YFLogxK

U2 - 10.1177/0956462419857005

DO - 10.1177/0956462419857005

M3 - Article

C2 - 31335273

AN - SCOPUS:85070409490

VL - 30

SP - 991

EP - 998

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 10

ER -