Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography

Juntao Li, Hengwei Zhang, Hui Jiang, Xuhui Guo, Yinli Zhang, Dan Qi, Jitian Guan, Zhenzhen Liu, Erxi Wu, Suxia Luo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) for breast suspicious calcifications from various populations is unclear. The objective of this study is to determine whether DBT exhibits the diagnostic advantage for breast suspicious calcifications from various populations compared with FFDM. Three hundred and five patients were enrolled (of which seven patients with bilateral lesions) and 312 breasts images were retrospectively analyzed by three radiologists independently. The postoperative pathology of breast calcifications was the gold standard. Breast cancer was diagnosed utilizing DBT and FFDM with sensitivities of 92.9% and 88.8%, specificities of 87.9% and 75.2%, positive predictive values of 77.8% and 62.1%, negative predictive values of 96.4% and 93.6%, respectively. DBT exhibited significantly higher diagnostic accuracy for benign calcifications compared with FFDM (87.9% vs 75.2%), and no advantage in the diagnosis of malignant calcifications. DBT diagnostic accuracy was notably higher than FFDM in premenopausal (88.4% vs 78.8%), postmenopausal (90.2% vs 77.2%), and dense breast cases (89.4% vs 81.9%). There was no significant difference in non-dense breast cases. In our study, DBT exhibited a superior advantage in dense breasts and benign calcifications cases compared to FFDM, while no advantage was observed in non-dense breasts or malignant calcifications cases. Thus, in the breast cancer screening for young women with dense breasts, DBT may be recommended for accurate diagnosis. Our findings may assist the clinicians in applying the optimal techniques for different patients and provide a theoretical basis for the update of breast cancer screening guideline.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalComputational and Structural Biotechnology Journal
Volume17
DOIs
StatePublished - Jan 1 2019

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Mammography
Breast
Population
Screening
Pathology
Breast Neoplasms
Early Detection of Cancer

Keywords

  • Breast suspicious calcification
  • Digital breast tomosynthesis
  • Full-field digital mammography

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

Cite this

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations : A Comparison With Full-field Digital Mammography. / Li, Juntao; Zhang, Hengwei; Jiang, Hui; Guo, Xuhui; Zhang, Yinli; Qi, Dan; Guan, Jitian; Liu, Zhenzhen; Wu, Erxi; Luo, Suxia.

In: Computational and Structural Biotechnology Journal, Vol. 17, 01.01.2019, p. 82-89.

Research output: Contribution to journalArticle

Li, Juntao ; Zhang, Hengwei ; Jiang, Hui ; Guo, Xuhui ; Zhang, Yinli ; Qi, Dan ; Guan, Jitian ; Liu, Zhenzhen ; Wu, Erxi ; Luo, Suxia. / Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations : A Comparison With Full-field Digital Mammography. In: Computational and Structural Biotechnology Journal. 2019 ; Vol. 17. pp. 82-89.
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abstract = "The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) for breast suspicious calcifications from various populations is unclear. The objective of this study is to determine whether DBT exhibits the diagnostic advantage for breast suspicious calcifications from various populations compared with FFDM. Three hundred and five patients were enrolled (of which seven patients with bilateral lesions) and 312 breasts images were retrospectively analyzed by three radiologists independently. The postoperative pathology of breast calcifications was the gold standard. Breast cancer was diagnosed utilizing DBT and FFDM with sensitivities of 92.9{\%} and 88.8{\%}, specificities of 87.9{\%} and 75.2{\%}, positive predictive values of 77.8{\%} and 62.1{\%}, negative predictive values of 96.4{\%} and 93.6{\%}, respectively. DBT exhibited significantly higher diagnostic accuracy for benign calcifications compared with FFDM (87.9{\%} vs 75.2{\%}), and no advantage in the diagnosis of malignant calcifications. DBT diagnostic accuracy was notably higher than FFDM in premenopausal (88.4{\%} vs 78.8{\%}), postmenopausal (90.2{\%} vs 77.2{\%}), and dense breast cases (89.4{\%} vs 81.9{\%}). There was no significant difference in non-dense breast cases. In our study, DBT exhibited a superior advantage in dense breasts and benign calcifications cases compared to FFDM, while no advantage was observed in non-dense breasts or malignant calcifications cases. Thus, in the breast cancer screening for young women with dense breasts, DBT may be recommended for accurate diagnosis. Our findings may assist the clinicians in applying the optimal techniques for different patients and provide a theoretical basis for the update of breast cancer screening guideline.",
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