Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

Diane C. Saunders, Marcela Brissova, Neil Phillips, Shristi Shrestha, John T. Walker, Radhika Aramandla, Greg Poffenberger, David K. Flaherty, Kevin P. Weller, Julie Pelletier, Tracy Cooper, Matt T. Goff, John Virostko, Alena Shostak, E. Danielle Dean, Dale L. Greiner, Leonard D. Shultz, Nripesh Prasad, Shawn E. Levy, Robert H. CarnahanChunhua Dai, Jean Sévigny, Alvin C. Powers

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Identification of human pancreatic β cell-specific markers is important in advancing our knowledge of human β cell development and physiology. Saunders et al. identify NTPDase3 as a highly enriched biomarker expressed on adult human β cells and show that an NTPDase3 antibody can be used for in vivo live β cell sorting and imaging.

Original languageEnglish (US)
Pages (from-to)745-754.e4
JournalCell Metabolism
Volume29
Issue number3
DOIs
StatePublished - Mar 5 2019

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Antibodies
Cell Physiological Phenomena
Forensic Anthropology
Human Development
Biomarkers
In Vitro Techniques
triphosphoric acid

Keywords

  • development
  • diabetes
  • glucagon
  • imaging
  • insulin
  • islet
  • pancreas

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Saunders, D. C., Brissova, M., Phillips, N., Shrestha, S., Walker, J. T., Aramandla, R., ... Powers, A. C. (2019). Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis. Cell Metabolism, 29(3), 745-754.e4. https://doi.org/10.1016/j.cmet.2018.10.007

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis. / Saunders, Diane C.; Brissova, Marcela; Phillips, Neil; Shrestha, Shristi; Walker, John T.; Aramandla, Radhika; Poffenberger, Greg; Flaherty, David K.; Weller, Kevin P.; Pelletier, Julie; Cooper, Tracy; Goff, Matt T.; Virostko, John; Shostak, Alena; Dean, E. Danielle; Greiner, Dale L.; Shultz, Leonard D.; Prasad, Nripesh; Levy, Shawn E.; Carnahan, Robert H.; Dai, Chunhua; Sévigny, Jean; Powers, Alvin C.

In: Cell Metabolism, Vol. 29, No. 3, 05.03.2019, p. 745-754.e4.

Research output: Contribution to journalArticle

Saunders, DC, Brissova, M, Phillips, N, Shrestha, S, Walker, JT, Aramandla, R, Poffenberger, G, Flaherty, DK, Weller, KP, Pelletier, J, Cooper, T, Goff, MT, Virostko, J, Shostak, A, Dean, ED, Greiner, DL, Shultz, LD, Prasad, N, Levy, SE, Carnahan, RH, Dai, C, Sévigny, J & Powers, AC 2019, 'Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis', Cell Metabolism, vol. 29, no. 3, pp. 745-754.e4. https://doi.org/10.1016/j.cmet.2018.10.007
Saunders, Diane C. ; Brissova, Marcela ; Phillips, Neil ; Shrestha, Shristi ; Walker, John T. ; Aramandla, Radhika ; Poffenberger, Greg ; Flaherty, David K. ; Weller, Kevin P. ; Pelletier, Julie ; Cooper, Tracy ; Goff, Matt T. ; Virostko, John ; Shostak, Alena ; Dean, E. Danielle ; Greiner, Dale L. ; Shultz, Leonard D. ; Prasad, Nripesh ; Levy, Shawn E. ; Carnahan, Robert H. ; Dai, Chunhua ; Sévigny, Jean ; Powers, Alvin C. / Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis. In: Cell Metabolism. 2019 ; Vol. 29, No. 3. pp. 745-754.e4.
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