Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing

Marissa E. Wechsler, Regan E. Stephenson, Andrew C. Murphy, Heidi F. Oldenkamp, Ankur Singh, Nicholas Peppas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Engineered microscale hydrogels have emerged as promising therapeutic approaches for the treatment of various diseases. These microgels find wide application in the biomedical field because of the ease of injectability, controlled release of therapeutics, flexible means of synthesis, associated tunability, and can be engineered as stimuli-responsive. While bulk hydrogels of several length-scale dimensions have been used for over two decades in drug delivery applications, their use as microscale carriers of drug and cell-based therapies is relatively new. Herein, we critically summarize the fundamentals of hydrogels based on their equilibrium and dynamics of their molecular structure, as well as solute diffusion as it relates to drug delivery. In addition, examples of common microgel synthesis techniques are provided. The ability to tune microscale hydrogels to obtain controlled release of therapeutics is discussed, along with microgel considerations for cell encapsulation as it relates to the development of cell-based therapies. We conclude with an outlook on the use of microgels for cell sequencing, and the convergence of the use of microscale hydrogels for drug delivery, cell therapy, and cell sequencing based systems.

Original languageEnglish (US)
Article number31
JournalBiomedical Microdevices
Volume21
Issue number2
DOIs
StatePublished - Jun 1 2019

Fingerprint

Hydrogels
Cell- and Tissue-Based Therapy
Drug delivery
Pharmaceutical Preparations
Drug Carriers
Therapeutics
Molecular Structure
Encapsulation
Molecular structure

Keywords

  • Cell therapy
  • Drug delivery
  • Hydrogels
  • Sequencing

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

Cite this

Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing. / Wechsler, Marissa E.; Stephenson, Regan E.; Murphy, Andrew C.; Oldenkamp, Heidi F.; Singh, Ankur; Peppas, Nicholas.

In: Biomedical Microdevices, Vol. 21, No. 2, 31, 01.06.2019.

Research output: Contribution to journalArticle

Wechsler, Marissa E. ; Stephenson, Regan E. ; Murphy, Andrew C. ; Oldenkamp, Heidi F. ; Singh, Ankur ; Peppas, Nicholas. / Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing. In: Biomedical Microdevices. 2019 ; Vol. 21, No. 2.
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