Hodgkin lymphoma involving Waldeyer ring

A clinicopathologic study of 22 cases

Maria Del Pilar Quiñones-Avila, Abel A. Gonzalez-Longoria, Joan Admirand, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

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Abstract

We report 22 cases of Hodgkin lymphoma involving Waldeyer ring seen at our institution during a 31-year interval. There were 16 males (73%) and 6 females (27%) with a median age of 48 years (range, 5-81 years), and 15 (68%) patients had airway obstruction or tonsillar enlargement. For 19 patients, the clinical stage was as follows: I, 7 (32%); II, 11 (50%); and III, 1 (5%). The 3 patients (14%) whose disease was unstaged had concurrent or a history of non-Hodgkin lymphoma. Histologically, the neoplasms were classified as follows: lymphocyte-rich classical, 8 (36%); nodular sclerosis, 7 (32%); mixed cellularity, 4 (18%); unclassified, 2 (9%); and lymphocyte depletion, 1 (5%). Of 7 stage I cases, 4 (57%) were the lymphocyte-rich classical type. Reed-Sternberg and Hodgkin cells were positive for CD15 and CD30 in 20 cases assessed. Epstein-Barr virus latent membrane protein type 1 was positive in 12 (67%) of 18 cases assessed. We conclude that Hodgkin lymphoma rarely involves Waldeyer ring, with the lymphocyte-rich classical type being common at this location.

Original languageEnglish (US)
Pages (from-to)651-656
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume123
Issue number5
DOIs
StatePublished - Jan 1 2005

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Hodgkin Disease
Lymphocytes
Lymphocyte Depletion
Reed-Sternberg Cells
Sclerosis
Airway Obstruction
Non-Hodgkin's Lymphoma
Neoplasms

Keywords

  • Epstein-Barr virus
  • Hodgkin lymphoma
  • Waldeyer ring

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hodgkin lymphoma involving Waldeyer ring : A clinicopathologic study of 22 cases. / Quiñones-Avila, Maria Del Pilar; Gonzalez-Longoria, Abel A.; Admirand, Joan; Medeiros, L. Jeffrey.

In: American Journal of Clinical Pathology, Vol. 123, No. 5, 01.01.2005, p. 651-656.

Research output: Contribution to journalArticle

Quiñones-Avila, Maria Del Pilar ; Gonzalez-Longoria, Abel A. ; Admirand, Joan ; Medeiros, L. Jeffrey. / Hodgkin lymphoma involving Waldeyer ring : A clinicopathologic study of 22 cases. In: American Journal of Clinical Pathology. 2005 ; Vol. 123, No. 5. pp. 651-656.
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