In vivo imaging to initialize a biophysical model of tumor growth: Preliminary results

David A. Hormuth, Thomas Yankeelov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent advances in MRI and PET have increased the availability of noninvasive measurements of the molecular, cellular, and physiological characteristics of tumors. It may be possible to incorporate these measurables into realistic biophysical models that can then be used to predict tumor growth and therapy response on an individual basis. Here we incorporate quantitative imaging data acquired during the course of a tumor development in rat model of glioma. Early measurements are used to initialize and constrain a biophysical model to predict tumor status at later time points. The initial results show a promising ability to use early time point data to predict later time point tumor size, cellularity, and distribution.

Original languageEnglish (US)
Title of host publicationProceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference
Subtitle of host publicationCollaborative Biomedical Innovations, BSEC 2013
DOIs
StatePublished - Nov 21 2013
Event2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013 - Oak Ridge, TN, United States
Duration: May 21 2013May 23 2013

Publication series

NameProceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013

Other

Other2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013
CountryUnited States
CityOak Ridge, TN
Period5/21/135/23/13

Fingerprint

Tumors
Imaging techniques
Magnetic resonance imaging
Rats
Availability

Keywords

  • MRI
  • PET
  • biophysical modeling
  • cancer

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Hormuth, D. A., & Yankeelov, T. (2013). In vivo imaging to initialize a biophysical model of tumor growth: Preliminary results. In Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013 [6618487] (Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013). https://doi.org/10.1109/BSEC.2013.6618487

In vivo imaging to initialize a biophysical model of tumor growth : Preliminary results. / Hormuth, David A.; Yankeelov, Thomas.

Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013. 2013. 6618487 (Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hormuth, DA & Yankeelov, T 2013, In vivo imaging to initialize a biophysical model of tumor growth: Preliminary results. in Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013., 6618487, Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013, 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013, Oak Ridge, TN, United States, 5/21/13. https://doi.org/10.1109/BSEC.2013.6618487
Hormuth DA, Yankeelov T. In vivo imaging to initialize a biophysical model of tumor growth: Preliminary results. In Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013. 2013. 6618487. (Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013). https://doi.org/10.1109/BSEC.2013.6618487
Hormuth, David A. ; Yankeelov, Thomas. / In vivo imaging to initialize a biophysical model of tumor growth : Preliminary results. Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013. 2013. (Proceedings of the 2013 4th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2013).
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