Infant milk-feeding practices and childhood leukemia

a systematic review

Darcy Güngör, Perrine Nadaud, Carol Dreibelbis, Concetta C. LaPergola, Yat Ping Wong, Nancy Terry, Steven Abrams, Leila Beker, Tova Jacobovits, Kirsi M. Järvinen, Laurie A. Nommsen-Rivers, Kimberly O. O'Brien, Emily Oken, Rafael Pérez-Escamilla, Ekhard E. Ziegler, Joanne M. Spahn

Research output: Contribution to journalArticle

Abstract

BACKGROUND: During the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations. OBJECTIVES: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with acute childhood leukemia, generally, and acute lymphoblastic leukemia, specifically. METHODS: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980 to March 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. RESULTS: We included 24 articles from case-control or retrospective studies. Limited evidence suggests that never feeding human milk versus 1) ever feeding human milk and 2) feeding human milk for durations ≥6 mo are associated with a slightly higher risk of acute childhood leukemia, whereas evidence comparing never feeding human milk with feeding human milk for durations <6 mo is mixed. Limited evidence suggests that, among infants fed human milk, a shorter versus longer duration of human milk feeding is associated with a slightly higher risk of acute childhood leukemia. None of the included articles examined exclusive human milk feeding or the intensity of human milk fed to mixed-fed infants. CONCLUSIONS: Feeding human milk for short durations or not at all may be associated with slightly higher acute childhood leukemia risk. The evidence could be strengthened with access to broadly generalizable prospective samples; therefore, we recommend linking surveillance systems that collect infant feeding and childhood cancer data.

Original languageEnglish (US)
Pages (from-to)757S-771S
JournalThe American journal of clinical nutrition
Volume109
Issue number7
DOIs
StatePublished - Mar 1 2019

Fingerprint

Human Milk
Leukemia
Milk
United States Dept. of Health and Human Services
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PubMed
Case-Control Studies
Retrospective Studies

Keywords

  • breast milk
  • breastfeeding
  • child
  • human milk
  • infant
  • leukemia
  • systematic review
  • toddler

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Güngör, D., Nadaud, P., Dreibelbis, C., LaPergola, C. C., Wong, Y. P., Terry, N., ... Spahn, J. M. (2019). Infant milk-feeding practices and childhood leukemia: a systematic review. The American journal of clinical nutrition, 109(7), 757S-771S. https://doi.org/10.1093/ajcn/nqy306

Infant milk-feeding practices and childhood leukemia : a systematic review. / Güngör, Darcy; Nadaud, Perrine; Dreibelbis, Carol; LaPergola, Concetta C.; Wong, Yat Ping; Terry, Nancy; Abrams, Steven; Beker, Leila; Jacobovits, Tova; Järvinen, Kirsi M.; Nommsen-Rivers, Laurie A.; O'Brien, Kimberly O.; Oken, Emily; Pérez-Escamilla, Rafael; Ziegler, Ekhard E.; Spahn, Joanne M.

In: The American journal of clinical nutrition, Vol. 109, No. 7, 01.03.2019, p. 757S-771S.

Research output: Contribution to journalArticle

Güngör, D, Nadaud, P, Dreibelbis, C, LaPergola, CC, Wong, YP, Terry, N, Abrams, S, Beker, L, Jacobovits, T, Järvinen, KM, Nommsen-Rivers, LA, O'Brien, KO, Oken, E, Pérez-Escamilla, R, Ziegler, EE & Spahn, JM 2019, 'Infant milk-feeding practices and childhood leukemia: a systematic review', The American journal of clinical nutrition, vol. 109, no. 7, pp. 757S-771S. https://doi.org/10.1093/ajcn/nqy306
Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N et al. Infant milk-feeding practices and childhood leukemia: a systematic review. The American journal of clinical nutrition. 2019 Mar 1;109(7):757S-771S. https://doi.org/10.1093/ajcn/nqy306
Güngör, Darcy ; Nadaud, Perrine ; Dreibelbis, Carol ; LaPergola, Concetta C. ; Wong, Yat Ping ; Terry, Nancy ; Abrams, Steven ; Beker, Leila ; Jacobovits, Tova ; Järvinen, Kirsi M. ; Nommsen-Rivers, Laurie A. ; O'Brien, Kimberly O. ; Oken, Emily ; Pérez-Escamilla, Rafael ; Ziegler, Ekhard E. ; Spahn, Joanne M. / Infant milk-feeding practices and childhood leukemia : a systematic review. In: The American journal of clinical nutrition. 2019 ; Vol. 109, No. 7. pp. 757S-771S.
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