Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review

Darcy Güngör, Perrine Nadaud, Concetta C. Lapergola, Carol Dreibelbis, Yat Ping Wong, Nancy Terry, Steve A. Abrams, Leila Beker, Tova Jacobovits, Kirsi M. Järvinen, Laurie A. Nommsen-Rivers, Kimberly O. O'Brien, Emily Oken, Rafael Pérez-Escamilla, Ekhard E. Ziegler, Joanne M. Spahn

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: During the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations. Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with type 1 and type 2 diabetes in offspring. Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980-March 2016, dual-screened the results according to predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: The 4 systematic reviews included 21, 37, 18, and 1 articles, respectively. Observational evidence suggests that never versus ever feeding human milk (limited evidence) and shorter versus longer durations of any (moderate evidence) and exclusive (limited evidence) human milk feeding are associated with higher type 1 diabetes risk. Insufficient evidence examined type 2 diabetes. Limited evidence suggests that the durations of any and exclusive human milk feeding are not associated with intermediate outcomes (e.g., fasting glucose, insulin resistance) during childhood. Conclusions: Limited to moderate evidence suggests that feeding less or no human milk is associated with higher risk of type 1 diabetes in offspring. Limited evidence suggests no associations between the durations of any and exclusive human milk feeding and intermediate diabetes outcomes in children. Additional research is needed on infant milk-feeding practices and type 2 diabetes and intermediate outcomes in US populations, which may have distinct metabolic risk.

Original languageEnglish (US)
Article numbernqy311
Pages (from-to)817S-837S
JournalAmerican Journal of Clinical Nutrition
Volume109
DOIs
StatePublished - Mar 1 2019

Fingerprint

Human Milk
Milk
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
United States Dept. of Health and Human Services
PubMed
Population
Insulin Resistance
Fasting
Parturition
Diet
Glucose
Pregnancy
Health
Research

Keywords

  • breast milk
  • breastfeeding
  • diabetes
  • fasting glucose
  • human milk
  • insulin resistance
  • systematic review

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Güngör, D., Nadaud, P., Lapergola, C. C., Dreibelbis, C., Wong, Y. P., Terry, N., ... Spahn, J. M. (2019). Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review. American Journal of Clinical Nutrition, 109, 817S-837S. [nqy311]. https://doi.org/10.1093/ajcn/nqy311

Infant milk-feeding practices and diabetes outcomes in offspring : A systematic review. / Güngör, Darcy; Nadaud, Perrine; Lapergola, Concetta C.; Dreibelbis, Carol; Wong, Yat Ping; Terry, Nancy; Abrams, Steve A.; Beker, Leila; Jacobovits, Tova; Järvinen, Kirsi M.; Nommsen-Rivers, Laurie A.; O'Brien, Kimberly O.; Oken, Emily; Pérez-Escamilla, Rafael; Ziegler, Ekhard E.; Spahn, Joanne M.

In: American Journal of Clinical Nutrition, Vol. 109, nqy311, 01.03.2019, p. 817S-837S.

Research output: Contribution to journalReview article

Güngör, D, Nadaud, P, Lapergola, CC, Dreibelbis, C, Wong, YP, Terry, N, Abrams, SA, Beker, L, Jacobovits, T, Järvinen, KM, Nommsen-Rivers, LA, O'Brien, KO, Oken, E, Pérez-Escamilla, R, Ziegler, EE & Spahn, JM 2019, 'Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review', American Journal of Clinical Nutrition, vol. 109, nqy311, pp. 817S-837S. https://doi.org/10.1093/ajcn/nqy311
Güngör D, Nadaud P, Lapergola CC, Dreibelbis C, Wong YP, Terry N et al. Infant milk-feeding practices and diabetes outcomes in offspring: A systematic review. American Journal of Clinical Nutrition. 2019 Mar 1;109:817S-837S. nqy311. https://doi.org/10.1093/ajcn/nqy311
Güngör, Darcy ; Nadaud, Perrine ; Lapergola, Concetta C. ; Dreibelbis, Carol ; Wong, Yat Ping ; Terry, Nancy ; Abrams, Steve A. ; Beker, Leila ; Jacobovits, Tova ; Järvinen, Kirsi M. ; Nommsen-Rivers, Laurie A. ; O'Brien, Kimberly O. ; Oken, Emily ; Pérez-Escamilla, Rafael ; Ziegler, Ekhard E. ; Spahn, Joanne M. / Infant milk-feeding practices and diabetes outcomes in offspring : A systematic review. In: American Journal of Clinical Nutrition. 2019 ; Vol. 109. pp. 817S-837S.
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AU - Abrams, Steve A.

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AU - O'Brien, Kimberly O.

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N2 - Background: During the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations. Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with type 1 and type 2 diabetes in offspring. Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980-March 2016, dual-screened the results according to predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: The 4 systematic reviews included 21, 37, 18, and 1 articles, respectively. Observational evidence suggests that never versus ever feeding human milk (limited evidence) and shorter versus longer durations of any (moderate evidence) and exclusive (limited evidence) human milk feeding are associated with higher type 1 diabetes risk. Insufficient evidence examined type 2 diabetes. Limited evidence suggests that the durations of any and exclusive human milk feeding are not associated with intermediate outcomes (e.g., fasting glucose, insulin resistance) during childhood. Conclusions: Limited to moderate evidence suggests that feeding less or no human milk is associated with higher risk of type 1 diabetes in offspring. Limited evidence suggests no associations between the durations of any and exclusive human milk feeding and intermediate diabetes outcomes in children. Additional research is needed on infant milk-feeding practices and type 2 diabetes and intermediate outcomes in US populations, which may have distinct metabolic risk.

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