Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: A systematic review

Darcy Güngör, Perrine Nadaud, Carol Dreibelbis, Concetta C. Lapergola, Yat Ping Wong, Nancy Terry, Steven Abrams, Leila Beker, Tova Jacobovits, Kirsi M. Järvinen, Laurie A. Nommsen-Rivers, Kimberly O. O'Brien, Emily Oken, Rafael Pérez-Escamilla, Ekhard E. Ziegler, Joanne M. Spahn

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations. Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD). Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January, 1980 to March, 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: We included 9 celiac disease and 17 IBD articles. Limited case-control evidence suggests never versus ever being fed human milk is associated with higher risk of celiac disease, but concerns about reverse causality precluded a conclusion about the relationship of shorter versus longer durations of any human milk feeding with celiac disease. Evidence examining never versus ever feeding human milk and IBD was inconclusive, and limited, but consistent, case-control evidence suggests that, among infants fed human milk, shorter versus longer durations of any human milk feeding are associated with higher risk of IBD. For both outcomes, evidence examining the duration of exclusive human milk feeding was scant and no articles examined the intensity of human milk fed to mixed-fed infants. Conclusion: Limited case-control evidence suggests that feeding human milk for short durations or not at all associates with higher risk of diagnosed IBD and celiac disease, respectively. The small number of studies and concern about reverse causality and recall bias prevent stronger conclusions.

Original languageEnglish (US)
Article numbernqy371
Pages (from-to)838S-851S
JournalAmerican Journal of Clinical Nutrition
Volume109
DOIs
StatePublished - Mar 1 2019

Fingerprint

Celiac Disease
Human Milk
Inflammatory Bowel Diseases
Milk
Causality
United States Dept. of Health and Human Services
United States Department of Agriculture
PubMed
Libraries
Parturition
Diet
Pregnancy

Keywords

  • Crohn disease
  • breast milk
  • breastfeeding
  • celiac disease
  • human milk
  • inflammatory bowel disease
  • systematic review
  • ulcerative colitis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Güngör, D., Nadaud, P., Dreibelbis, C., Lapergola, C. C., Wong, Y. P., Terry, N., ... Spahn, J. M. (2019). Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: A systematic review. American Journal of Clinical Nutrition, 109, 838S-851S. [nqy371]. https://doi.org/10.1093/ajcn/nqy371

Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring : A systematic review. / Güngör, Darcy; Nadaud, Perrine; Dreibelbis, Carol; Lapergola, Concetta C.; Wong, Yat Ping; Terry, Nancy; Abrams, Steven; Beker, Leila; Jacobovits, Tova; Järvinen, Kirsi M.; Nommsen-Rivers, Laurie A.; O'Brien, Kimberly O.; Oken, Emily; Pérez-Escamilla, Rafael; Ziegler, Ekhard E.; Spahn, Joanne M.

In: American Journal of Clinical Nutrition, Vol. 109, nqy371, 01.03.2019, p. 838S-851S.

Research output: Contribution to journalReview article

Güngör, D, Nadaud, P, Dreibelbis, C, Lapergola, CC, Wong, YP, Terry, N, Abrams, S, Beker, L, Jacobovits, T, Järvinen, KM, Nommsen-Rivers, LA, O'Brien, KO, Oken, E, Pérez-Escamilla, R, Ziegler, EE & Spahn, JM 2019, 'Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: A systematic review', American Journal of Clinical Nutrition, vol. 109, nqy371, pp. 838S-851S. https://doi.org/10.1093/ajcn/nqy371
Güngör, Darcy ; Nadaud, Perrine ; Dreibelbis, Carol ; Lapergola, Concetta C. ; Wong, Yat Ping ; Terry, Nancy ; Abrams, Steven ; Beker, Leila ; Jacobovits, Tova ; Järvinen, Kirsi M. ; Nommsen-Rivers, Laurie A. ; O'Brien, Kimberly O. ; Oken, Emily ; Pérez-Escamilla, Rafael ; Ziegler, Ekhard E. ; Spahn, Joanne M. / Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring : A systematic review. In: American Journal of Clinical Nutrition. 2019 ; Vol. 109. pp. 838S-851S.
@article{a2773c71707b4355a477f2648fb40d6b,
title = "Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: A systematic review",
abstract = "Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations. Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD). Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January, 1980 to March, 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: We included 9 celiac disease and 17 IBD articles. Limited case-control evidence suggests never versus ever being fed human milk is associated with higher risk of celiac disease, but concerns about reverse causality precluded a conclusion about the relationship of shorter versus longer durations of any human milk feeding with celiac disease. Evidence examining never versus ever feeding human milk and IBD was inconclusive, and limited, but consistent, case-control evidence suggests that, among infants fed human milk, shorter versus longer durations of any human milk feeding are associated with higher risk of IBD. For both outcomes, evidence examining the duration of exclusive human milk feeding was scant and no articles examined the intensity of human milk fed to mixed-fed infants. Conclusion: Limited case-control evidence suggests that feeding human milk for short durations or not at all associates with higher risk of diagnosed IBD and celiac disease, respectively. The small number of studies and concern about reverse causality and recall bias prevent stronger conclusions.",
keywords = "Crohn disease, breast milk, breastfeeding, celiac disease, human milk, inflammatory bowel disease, systematic review, ulcerative colitis",
author = "Darcy G{\"u}ng{\"o}r and Perrine Nadaud and Carol Dreibelbis and Lapergola, {Concetta C.} and Wong, {Yat Ping} and Nancy Terry and Steven Abrams and Leila Beker and Tova Jacobovits and J{\"a}rvinen, {Kirsi M.} and Nommsen-Rivers, {Laurie A.} and O'Brien, {Kimberly O.} and Emily Oken and Rafael P{\'e}rez-Escamilla and Ziegler, {Ekhard E.} and Spahn, {Joanne M.}",
year = "2019",
month = "3",
day = "1",
doi = "10.1093/ajcn/nqy371",
language = "English (US)",
volume = "109",
pages = "838S--851S",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",

}

TY - JOUR

T1 - Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring

T2 - A systematic review

AU - Güngör, Darcy

AU - Nadaud, Perrine

AU - Dreibelbis, Carol

AU - Lapergola, Concetta C.

AU - Wong, Yat Ping

AU - Terry, Nancy

AU - Abrams, Steven

AU - Beker, Leila

AU - Jacobovits, Tova

AU - Järvinen, Kirsi M.

AU - Nommsen-Rivers, Laurie A.

AU - O'Brien, Kimberly O.

AU - Oken, Emily

AU - Pérez-Escamilla, Rafael

AU - Ziegler, Ekhard E.

AU - Spahn, Joanne M.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations. Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD). Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January, 1980 to March, 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: We included 9 celiac disease and 17 IBD articles. Limited case-control evidence suggests never versus ever being fed human milk is associated with higher risk of celiac disease, but concerns about reverse causality precluded a conclusion about the relationship of shorter versus longer durations of any human milk feeding with celiac disease. Evidence examining never versus ever feeding human milk and IBD was inconclusive, and limited, but consistent, case-control evidence suggests that, among infants fed human milk, shorter versus longer durations of any human milk feeding are associated with higher risk of IBD. For both outcomes, evidence examining the duration of exclusive human milk feeding was scant and no articles examined the intensity of human milk fed to mixed-fed infants. Conclusion: Limited case-control evidence suggests that feeding human milk for short durations or not at all associates with higher risk of diagnosed IBD and celiac disease, respectively. The small number of studies and concern about reverse causality and recall bias prevent stronger conclusions.

AB - Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations. Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD). Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January, 1980 to March, 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results: We included 9 celiac disease and 17 IBD articles. Limited case-control evidence suggests never versus ever being fed human milk is associated with higher risk of celiac disease, but concerns about reverse causality precluded a conclusion about the relationship of shorter versus longer durations of any human milk feeding with celiac disease. Evidence examining never versus ever feeding human milk and IBD was inconclusive, and limited, but consistent, case-control evidence suggests that, among infants fed human milk, shorter versus longer durations of any human milk feeding are associated with higher risk of IBD. For both outcomes, evidence examining the duration of exclusive human milk feeding was scant and no articles examined the intensity of human milk fed to mixed-fed infants. Conclusion: Limited case-control evidence suggests that feeding human milk for short durations or not at all associates with higher risk of diagnosed IBD and celiac disease, respectively. The small number of studies and concern about reverse causality and recall bias prevent stronger conclusions.

KW - Crohn disease

KW - breast milk

KW - breastfeeding

KW - celiac disease

KW - human milk

KW - inflammatory bowel disease

KW - systematic review

KW - ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=85064852584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064852584&partnerID=8YFLogxK

U2 - 10.1093/ajcn/nqy371

DO - 10.1093/ajcn/nqy371

M3 - Review article

C2 - 30982875

AN - SCOPUS:85064852584

VL - 109

SP - 838S-851S

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

M1 - nqy371

ER -