Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode

Fabiano G. Nery, Wade A. Weber, Thomas J. Blom, Jeffrey Welge, Luis R. Patino, Jeffrey R. Strawn, Wen Jang Chu, Caleb M. Adler, Richard A. Komoroski, Stephen Strakowski, Melissa P. DelBello

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.

Original languageEnglish (US)
Pages (from-to)330-341
Number of pages12
JournalBipolar Disorders
Volume21
Issue number4
DOIs
StatePublished - Jun 1 2019

Fingerprint

Prefrontal Cortex
Bipolar Disorder
Protons
Spectrum Analysis
Gyrus Cinguli
Psychotic Affective Disorders
Phosphocreatine
Creatine
Inositol
Survival Analysis
Choline
Glutamic Acid
Parents
Control Groups
Brain

Keywords

  • at-risk
  • bipolar disorder
  • magnetic resonance spectroscopy
  • phosphocreatine and creatine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Nery, F. G., Weber, W. A., Blom, T. J., Welge, J., Patino, L. R., Strawn, J. R., ... DelBello, M. P. (2019). Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode. Bipolar Disorders, 21(4), 330-341. https://doi.org/10.1111/bdi.12770

Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode. / Nery, Fabiano G.; Weber, Wade A.; Blom, Thomas J.; Welge, Jeffrey; Patino, Luis R.; Strawn, Jeffrey R.; Chu, Wen Jang; Adler, Caleb M.; Komoroski, Richard A.; Strakowski, Stephen; DelBello, Melissa P.

In: Bipolar Disorders, Vol. 21, No. 4, 01.06.2019, p. 330-341.

Research output: Contribution to journalArticle

Nery, FG, Weber, WA, Blom, TJ, Welge, J, Patino, LR, Strawn, JR, Chu, WJ, Adler, CM, Komoroski, RA, Strakowski, S & DelBello, MP 2019, 'Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode', Bipolar Disorders, vol. 21, no. 4, pp. 330-341. https://doi.org/10.1111/bdi.12770
Nery, Fabiano G. ; Weber, Wade A. ; Blom, Thomas J. ; Welge, Jeffrey ; Patino, Luis R. ; Strawn, Jeffrey R. ; Chu, Wen Jang ; Adler, Caleb M. ; Komoroski, Richard A. ; Strakowski, Stephen ; DelBello, Melissa P. / Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode. In: Bipolar Disorders. 2019 ; Vol. 21, No. 4. pp. 330-341.
@article{372eb8b84ee04a33973757b4d2dadf11,
title = "Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode",
abstract = "Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95{\%} CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.",
keywords = "at-risk, bipolar disorder, magnetic resonance spectroscopy, phosphocreatine and creatine",
author = "Nery, {Fabiano G.} and Weber, {Wade A.} and Blom, {Thomas J.} and Jeffrey Welge and Patino, {Luis R.} and Strawn, {Jeffrey R.} and Chu, {Wen Jang} and Adler, {Caleb M.} and Komoroski, {Richard A.} and Stephen Strakowski and DelBello, {Melissa P.}",
year = "2019",
month = "6",
day = "1",
doi = "10.1111/bdi.12770",
language = "English (US)",
volume = "21",
pages = "330--341",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "4",

}

TY - JOUR

T1 - Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode

AU - Nery, Fabiano G.

AU - Weber, Wade A.

AU - Blom, Thomas J.

AU - Welge, Jeffrey

AU - Patino, Luis R.

AU - Strawn, Jeffrey R.

AU - Chu, Wen Jang

AU - Adler, Caleb M.

AU - Komoroski, Richard A.

AU - Strakowski, Stephen

AU - DelBello, Melissa P.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.

AB - Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.

KW - at-risk

KW - bipolar disorder

KW - magnetic resonance spectroscopy

KW - phosphocreatine and creatine

UR - http://www.scopus.com/inward/record.url?scp=85063463478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063463478&partnerID=8YFLogxK

U2 - 10.1111/bdi.12770

DO - 10.1111/bdi.12770

M3 - Article

VL - 21

SP - 330

EP - 341

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 4

ER -