Abstract
Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 330-341 |
| Number of pages | 12 |
| Journal | Bipolar Disorders |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 1 2019 |
Fingerprint
Keywords
- at-risk
- bipolar disorder
- magnetic resonance spectroscopy
- phosphocreatine and creatine
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode. / Nery, Fabiano G.; Weber, Wade A.; Blom, Thomas J.; Welge, Jeffrey; Patino, Luis R.; Strawn, Jeffrey R.; Chu, Wen Jang; Adler, Caleb M.; Komoroski, Richard A.; Strakowski, Stephen; DelBello, Melissa P.
In: Bipolar Disorders, Vol. 21, No. 4, 01.06.2019, p. 330-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode
AU - Nery, Fabiano G.
AU - Weber, Wade A.
AU - Blom, Thomas J.
AU - Welge, Jeffrey
AU - Patino, Luis R.
AU - Strawn, Jeffrey R.
AU - Chu, Wen Jang
AU - Adler, Caleb M.
AU - Komoroski, Richard A.
AU - Strakowski, Stephen
AU - DelBello, Melissa P.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.
AB - Objectives: To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods: Children and adolescents offspring of parents with bipolar I disorder (at-risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At-risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N-acetyl-aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline-containing compounds, myo-inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results: There were no baseline differences in metabolite levels for any of the brain regions between at-risk and HC youth. Nineteen at-risk subjects developed a first mood episode during follow-up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow-up in the at-risk group (HR: 0.47, 95% CI: 0.27-0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at-risk subjects. Conclusions: We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at-risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.
KW - at-risk
KW - bipolar disorder
KW - magnetic resonance spectroscopy
KW - phosphocreatine and creatine
UR - http://www.scopus.com/inward/record.url?scp=85063463478&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063463478&partnerID=8YFLogxK
U2 - 10.1111/bdi.12770
DO - 10.1111/bdi.12770
M3 - Article
C2 - 30864200
AN - SCOPUS:85063463478
VL - 21
SP - 330
EP - 341
JO - Bipolar Disorders
JF - Bipolar Disorders
SN - 1398-5647
IS - 4
ER -