Multi-modal inter-subject registration of mouse brain images

Xia Li, Thomas E. Yankeelov, Glenn Rosen, John C. Gore, Benoit M. Dawant

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The importance of small animal imaging in fundamental and clinical research is growing rapidly. These studies typically involve micro PET, micro MR, and micro CT images as well as optical or fluorescence images. Histological images are also often used to complement and/or validate the in vivo data. As is the case for human studies, automatic registration of these imaging modalities is a critical component of the overall analysis process, but, the small size of the animals and thus the limited spatial resolution of the in vivo images present specific challenges. In this paper, we propose a series of methods and techniques that permit the inter-subject registration of micro MR and histological images. We then compare results obtained by registering directly MR volumes to each other using a non-rigid registration algorithm we have developed at our institution with results obtained by registering first the MR volumes to their corresponding histological volume, which we reconstruct from 2D cross-sections, and then registering histological volumes to each other. We show that the second approach is preferable.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2006
Subtitle of host publicationImage Processing
DOIs
StatePublished - Jun 22 2006
EventMedical Imaging 2006: Image Processing - San Diego, CA, United States
Duration: Feb 13 2006Feb 16 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6144 I
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2006: Image Processing
CountryUnited States
CitySan Diego, CA
Period2/13/062/16/06

Fingerprint

Brain
Animals
Imaging techniques
Fluorescence

Keywords

  • Atlas
  • Image segmentation
  • Reconstruction
  • Registration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Li, X., Yankeelov, T. E., Rosen, G., Gore, J. C., & Dawant, B. M. (2006). Multi-modal inter-subject registration of mouse brain images. In Medical Imaging 2006: Image Processing [61440T] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6144 I). https://doi.org/10.1117/12.652407

Multi-modal inter-subject registration of mouse brain images. / Li, Xia; Yankeelov, Thomas E.; Rosen, Glenn; Gore, John C.; Dawant, Benoit M.

Medical Imaging 2006: Image Processing. 2006. 61440T (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6144 I).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, X, Yankeelov, TE, Rosen, G, Gore, JC & Dawant, BM 2006, Multi-modal inter-subject registration of mouse brain images. in Medical Imaging 2006: Image Processing., 61440T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6144 I, Medical Imaging 2006: Image Processing, San Diego, CA, United States, 2/13/06. https://doi.org/10.1117/12.652407
Li X, Yankeelov TE, Rosen G, Gore JC, Dawant BM. Multi-modal inter-subject registration of mouse brain images. In Medical Imaging 2006: Image Processing. 2006. 61440T. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.652407
Li, Xia ; Yankeelov, Thomas E. ; Rosen, Glenn ; Gore, John C. ; Dawant, Benoit M. / Multi-modal inter-subject registration of mouse brain images. Medical Imaging 2006: Image Processing. 2006. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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