Neutrophils as determinants of vascular stability in the injured spinal cord

Alpa Trivedi, Sang Mi Lee, Haoqian Zhang, Linda Noble

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

While a number of studies have examined the complex roles of leukocytes in the acute and chronically injured cord, few have specifically focused on neutrophils, where we have only recently begun to appreciate their involvement in both vascular pathogenesis and early wound healing. Here we address the mechanisms underlying neutrophil-mediated endothelial destabilization, their synergism with monocytes in modulating permeability, and their putative role as initiators of angiogenesis in the acutely injured spinal cord. Neutrophils contain a variety of bioactive molecules that are stored in granules. Studies have shown that certain of these molecules, and most notably proteases, contribute to endothelial destabilization as neutrophils degranulate during their transmigration across this front. Neutrophils have historically been regarded as detrimental to the acutely injured cord. However, there is growing evidence that this may be an oversimplified view as it fails to take into account their ability to release proteases that degrade the extracellular matrix, releasing latent growth factors that may in turn support early angiogenesis.

Original languageEnglish (US)
Title of host publicationVascular Mechanisms in CNS Trauma
PublisherSpringer New York
Pages285-302
Number of pages18
ISBN (Electronic)9781461486909
ISBN (Print)9781461486893
DOIs
StatePublished - Jan 1 2014

Fingerprint

Blood Vessels
Spinal Cord
Neutrophils
Peptide Hydrolases
Wound Healing
Extracellular Matrix
Monocytes
Permeability
Intercellular Signaling Peptides and Proteins
Leukocytes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Trivedi, A., Lee, S. M., Zhang, H., & Noble, L. (2014). Neutrophils as determinants of vascular stability in the injured spinal cord. In Vascular Mechanisms in CNS Trauma (pp. 285-302). Springer New York. https://doi.org/10.1007/978-1-4614-8690-9_16

Neutrophils as determinants of vascular stability in the injured spinal cord. / Trivedi, Alpa; Lee, Sang Mi; Zhang, Haoqian; Noble, Linda.

Vascular Mechanisms in CNS Trauma. Springer New York, 2014. p. 285-302.

Research output: Chapter in Book/Report/Conference proceedingChapter

Trivedi, A, Lee, SM, Zhang, H & Noble, L 2014, Neutrophils as determinants of vascular stability in the injured spinal cord. in Vascular Mechanisms in CNS Trauma. Springer New York, pp. 285-302. https://doi.org/10.1007/978-1-4614-8690-9_16
Trivedi A, Lee SM, Zhang H, Noble L. Neutrophils as determinants of vascular stability in the injured spinal cord. In Vascular Mechanisms in CNS Trauma. Springer New York. 2014. p. 285-302 https://doi.org/10.1007/978-1-4614-8690-9_16
Trivedi, Alpa ; Lee, Sang Mi ; Zhang, Haoqian ; Noble, Linda. / Neutrophils as determinants of vascular stability in the injured spinal cord. Vascular Mechanisms in CNS Trauma. Springer New York, 2014. pp. 285-302
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