New approaches towards the discovery and evaluation of bioactive peptides from natural resources

Nam Joo Kang, Hyeon Su Jin, Sung Eun Lee, Hyun Jung Kim, Hong Koh, Dong Woo Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition.

Original languageEnglish (US)
Pages (from-to)72-103
Number of pages32
JournalCritical Reviews in Environmental Science and Technology
Volume50
Issue number1
DOIs
StatePublished - Jan 2 2020

Fingerprint

Natural resources
peptide
Peptides
natural resource
Proteins
protein
genome
Genes
Proteolysis
informatics
health and nutrition
pharmaceutical industry
Biocatalysts
production cost
Nutrition
evaluation
Metabolism
Drug products
bioavailability
targeting

Keywords

  • Bioactive peptides
  • hydrolysis
  • informatics
  • protease
  • therapeutics

ASJC Scopus subject areas

  • Environmental Engineering
  • Water Science and Technology
  • Waste Management and Disposal
  • Pollution

Cite this

New approaches towards the discovery and evaluation of bioactive peptides from natural resources. / Kang, Nam Joo; Jin, Hyeon Su; Lee, Sung Eun; Kim, Hyun Jung; Koh, Hong; Lee, Dong Woo.

In: Critical Reviews in Environmental Science and Technology, Vol. 50, No. 1, 02.01.2020, p. 72-103.

Research output: Contribution to journalArticle

Kang, Nam Joo ; Jin, Hyeon Su ; Lee, Sung Eun ; Kim, Hyun Jung ; Koh, Hong ; Lee, Dong Woo. / New approaches towards the discovery and evaluation of bioactive peptides from natural resources. In: Critical Reviews in Environmental Science and Technology. 2020 ; Vol. 50, No. 1. pp. 72-103.
@article{3b1085cc0f8d45aca45a4f4d02687c20,
title = "New approaches towards the discovery and evaluation of bioactive peptides from natural resources",
abstract = "Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition.",
keywords = "Bioactive peptides, hydrolysis, informatics, protease, therapeutics",
author = "Kang, {Nam Joo} and Jin, {Hyeon Su} and Lee, {Sung Eun} and Kim, {Hyun Jung} and Hong Koh and Lee, {Dong Woo}",
year = "2020",
month = "1",
day = "2",
doi = "10.1080/10643389.2019.1619376",
language = "English (US)",
volume = "50",
pages = "72--103",
journal = "Critical Reviews in Environmental Science and Technology",
issn = "1064-3389",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

TY - JOUR

T1 - New approaches towards the discovery and evaluation of bioactive peptides from natural resources

AU - Kang, Nam Joo

AU - Jin, Hyeon Su

AU - Lee, Sung Eun

AU - Kim, Hyun Jung

AU - Koh, Hong

AU - Lee, Dong Woo

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition.

AB - Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition.

KW - Bioactive peptides

KW - hydrolysis

KW - informatics

KW - protease

KW - therapeutics

UR - http://www.scopus.com/inward/record.url?scp=85067045630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067045630&partnerID=8YFLogxK

U2 - 10.1080/10643389.2019.1619376

DO - 10.1080/10643389.2019.1619376

M3 - Article

AN - SCOPUS:85067045630

VL - 50

SP - 72

EP - 103

JO - Critical Reviews in Environmental Science and Technology

JF - Critical Reviews in Environmental Science and Technology

SN - 1064-3389

IS - 1

ER -