Noninvasive skin cancer diagnosis using multimodal optical spectroscopy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Skin cancer is the most common form of cancer in the United States and is a recognized public health issue. Diagnosis of skin cancer involves biopsy of the suspicious lesion followed by histopathology. Biopsies, which involve excision of the lesion, are invasive, at times unnecessary, and are costly procedures (∼$2.8B/year in the US). An unmet critical need exists to develop a non-invasive and inexpensive screening method that can eliminate the need for unnecessary biopsies. To address this need, our group has reported on the continued development of a multimodal spectroscopy (MMS) system towards the goal of a spectral biopsy of skin. Our approach combines Raman spectroscopy, fluorescence spectroscopy, and diffuse reflectance spectroscopy to collect comprehensive optical property information from suspicious skin lesions. We describe our present efforts to develop an updated MMS system composed of OEM components that will be smaller, less expensive, and more clinic-friendly than the previous system. Key system design choices include the selection of miniature spectrometers, a fiber-coupled broadband light source, a fiber coupled diode laser, and a revised optical probe. Selection of these components results in a ∼50% reduction in system footprint, resulting in a more clinic-friendly system. We also present preliminary characterization data from the updated MMS system, showing similar performance with our revised optical probe design. Finally, we present in vivo skin measurements taken with the updated MMS system. Future work includes the initiation of a clinical study (n = 250) of the MMS system to characterize its performance in identifying skin cancers.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics XII
EditorsAndreas Mandelis, Bernard Choi, Brian J. F. Wong, Justus F. Ilgner, Laura Marcu, Melissa C. Skala, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Guillermo J. Tearney, Kenton W. Gregory, Paul J. Campagnola
PublisherSPIE
ISBN (Electronic)9781628419245
DOIs
StatePublished - Jan 1 2016
EventPhotonic Therapeutics and Diagnostics XII - San Francisco, United States
Duration: Feb 13 2016Feb 14 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9689
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics XII
CountryUnited States
CitySan Francisco
Period2/13/162/14/16

Fingerprint

Skin Neoplasms
Spectrum Analysis
Skin
Biopsy
cancer
Spectroscopy
spectroscopy
Optical fiber coupling
lesions
Unnecessary Procedures
Semiconductor Lasers
Raman Spectrum Analysis
Fluorescence Spectrometry
public health
Fluorescence spectroscopy
Public health
fibers
probes
footprints
Light sources

Keywords

  • Diffuse reflectance
  • Fluorescence
  • Multimodal
  • Raman
  • Skin cancer
  • Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Moy, A. J., Feng, X., Markey, M. K., Reichenberg, J. S., & Tunnell, J. W. (2016). Noninvasive skin cancer diagnosis using multimodal optical spectroscopy. In A. Mandelis, B. Choi, B. J. F. Wong, J. F. Ilgner, L. Marcu, M. C. Skala, N. Kollias, H. Zeng, H. W. Kang, G. J. Tearney, K. W. Gregory, ... P. J. Campagnola (Eds.), Photonic Therapeutics and Diagnostics XII [968905] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9689). SPIE. https://doi.org/10.1117/12.2211172

Noninvasive skin cancer diagnosis using multimodal optical spectroscopy. / Moy, Austin J.; Feng, Xu; Markey, Mia K.; Reichenberg, Jason S.; Tunnell, James W.

Photonic Therapeutics and Diagnostics XII. ed. / Andreas Mandelis; Bernard Choi; Brian J. F. Wong; Justus F. Ilgner; Laura Marcu; Melissa C. Skala; Nikiforos Kollias; Haishan Zeng; Hyun Wook Kang; Guillermo J. Tearney; Kenton W. Gregory; Paul J. Campagnola. SPIE, 2016. 968905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9689).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Moy, AJ, Feng, X, Markey, MK, Reichenberg, JS & Tunnell, JW 2016, Noninvasive skin cancer diagnosis using multimodal optical spectroscopy. in A Mandelis, B Choi, BJF Wong, JF Ilgner, L Marcu, MC Skala, N Kollias, H Zeng, HW Kang, GJ Tearney, KW Gregory & PJ Campagnola (eds), Photonic Therapeutics and Diagnostics XII., 968905, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9689, SPIE, Photonic Therapeutics and Diagnostics XII, San Francisco, United States, 2/13/16. https://doi.org/10.1117/12.2211172
Moy AJ, Feng X, Markey MK, Reichenberg JS, Tunnell JW. Noninvasive skin cancer diagnosis using multimodal optical spectroscopy. In Mandelis A, Choi B, Wong BJF, Ilgner JF, Marcu L, Skala MC, Kollias N, Zeng H, Kang HW, Tearney GJ, Gregory KW, Campagnola PJ, editors, Photonic Therapeutics and Diagnostics XII. SPIE. 2016. 968905. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2211172
Moy, Austin J. ; Feng, Xu ; Markey, Mia K. ; Reichenberg, Jason S. ; Tunnell, James W. / Noninvasive skin cancer diagnosis using multimodal optical spectroscopy. Photonic Therapeutics and Diagnostics XII. editor / Andreas Mandelis ; Bernard Choi ; Brian J. F. Wong ; Justus F. Ilgner ; Laura Marcu ; Melissa C. Skala ; Nikiforos Kollias ; Haishan Zeng ; Hyun Wook Kang ; Guillermo J. Tearney ; Kenton W. Gregory ; Paul J. Campagnola. SPIE, 2016. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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