Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging: Preliminary in vitro and in vivo results

Marshall Mahoney, Anna Sorace, Bryant Harbin, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Noninvasive assessment of renal perfusion would help improve treatment and outcome for patients with acute kidney injury. Although there are current methods with the capability of imaging and quantifying renal vascularity perfusion parameters, the nephrotoxic nature of their contrast agents prevents their use on compromised kidneys. Ultrasound (US) contrast agents are both non-toxic and capable of enhancing visualization of vasculature by up to 25 dB. Described in this study are preliminary results for quantifying perfusion parameters in a flow phantom and rat kidney model with volumetric contrast-enhanced US (VCEUS) imaging. Results showed significant correlations between time-to-peak intensity and concentration flow rate in a phantom model (P < 0.05). Renal perfusion experiments in healthy rats validate VCEUS as a valuable tool for obtaining consistent time-intensity curves and parametric perfusion information. Further study is expected to reveal the advantageous nature of VCEUS for compromised and ischemic kidneys compared to alternative imaging modalities.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages2157-2160
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Fingerprint

replenishment
destruction
kidneys
rats
flow velocity
curves

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Mahoney, M., Sorace, A., Harbin, B., & Hoyt, K. (2012). Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging: Preliminary in vitro and in vivo results. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 2157-2160). [6562200] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0538

Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging : Preliminary in vitro and in vivo results. / Mahoney, Marshall; Sorace, Anna; Harbin, Bryant; Hoyt, Kenneth.

2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 2157-2160 6562200 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mahoney, M, Sorace, A, Harbin, B & Hoyt, K 2012, Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging: Preliminary in vitro and in vivo results. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562200, IEEE International Ultrasonics Symposium, IUS, pp. 2157-2160, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0538
Mahoney M, Sorace A, Harbin B, Hoyt K. Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging: Preliminary in vitro and in vivo results. In 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 2157-2160. 6562200. (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0538
Mahoney, Marshall ; Sorace, Anna ; Harbin, Bryant ; Hoyt, Kenneth. / Real-time volumetric contrast-enhanced ultrasound and microbubble destruction-replenishment imaging : Preliminary in vitro and in vivo results. 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. pp. 2157-2160 (IEEE International Ultrasonics Symposium, IUS).
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