Spectral biopsy for skin cancer diagnosis: Initial clinical results

Austin J. Moy, Xu Feng, Hieu T.M. Nguyen, Yao Zhang, Katherine R. Sebastian, Jason S. Reichenberg, James W. Tunnell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Skin cancer is the most common form of cancer in the United States and is a recognized public health issue. Diagnosis of skin cancer involves biopsy of the suspicious lesion followed by histopathology. Biopsies, which involve excision of the lesion, are invasive, at times unnecessary, and are costly procedures (∼$2.8B/year in the US). An unmet critical need exists to develop a non-invasive and inexpensive screening method that can eliminate the need for unnecessary biopsies. To address this need, our group has reported on the continued development of a noninvasive method that utilizes multimodal spectroscopy towards the goal of a "spectral biopsy" of skin. Our approach combines Raman spectroscopy, fluorescence spectroscopy, and diffuse reflectance spectroscopy to collect comprehensive optical property information from suspicious skin lesions. We previously described an updated spectral biopsy system that allows acquisition of all three forms of spectroscopy through a single fiber optic probe and is composed of off-the-shelf OEM components that are smaller, cheaper, and enable a more clinic-friendly system. We present initial patient data acquired with the spectral biopsy system, the first from an extensive clinical study (n = 250) to characterize its performance in identifying skin cancers (basal cell carcinoma, squamous cell carcinoma, and melanoma). We also present our first attempts at analyzing this initial set of clinical data using statistical-based models, and with models currently being developed to extract biophysical information from the collected spectra, all towards the goal of noninvasive skin cancer diagnosis.

Original languageEnglish (US)
Title of host publicationPhotonics in Dermatology and Plastic Surgery
EditorsHaishan Zeng, Bernard Choi
PublisherSPIE
ISBN (Electronic)9781510605152
DOIs
StatePublished - Jan 1 2017
EventPhotonics in Dermatology and Plastic Surgery - San Francisco, United States
Duration: Jan 28 2017Jan 29 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10037
ISSN (Print)1605-7422

Other

OtherPhotonics in Dermatology and Plastic Surgery
CountryUnited States
CitySan Francisco
Period1/28/171/29/17

Fingerprint

Biopsy
Skin Neoplasms
Skin
cancer
Spectrum Analysis
lesions
Spectroscopy
spectroscopy
Unnecessary Procedures
Raman Spectrum Analysis
Basal Cell Carcinoma
Fluorescence Spectrometry
public health
Fluorescence spectroscopy
Statistical Models
Public health
Fiber optics
Raman spectroscopy
Squamous Cell Carcinoma
shelves

Keywords

  • Raman
  • diffuse reflectance
  • fluorescence
  • multimodal
  • skin cancer
  • spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Moy, A. J., Feng, X., Nguyen, H. T. M., Zhang, Y., Sebastian, K. R., Reichenberg, J. S., & Tunnell, J. W. (2017). Spectral biopsy for skin cancer diagnosis: Initial clinical results. In H. Zeng, & B. Choi (Eds.), Photonics in Dermatology and Plastic Surgery [1003704] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10037). SPIE. https://doi.org/10.1117/12.2251293

Spectral biopsy for skin cancer diagnosis : Initial clinical results. / Moy, Austin J.; Feng, Xu; Nguyen, Hieu T.M.; Zhang, Yao; Sebastian, Katherine R.; Reichenberg, Jason S.; Tunnell, James W.

Photonics in Dermatology and Plastic Surgery. ed. / Haishan Zeng; Bernard Choi. SPIE, 2017. 1003704 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10037).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Moy, AJ, Feng, X, Nguyen, HTM, Zhang, Y, Sebastian, KR, Reichenberg, JS & Tunnell, JW 2017, Spectral biopsy for skin cancer diagnosis: Initial clinical results. in H Zeng & B Choi (eds), Photonics in Dermatology and Plastic Surgery., 1003704, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10037, SPIE, Photonics in Dermatology and Plastic Surgery, San Francisco, United States, 1/28/17. https://doi.org/10.1117/12.2251293
Moy AJ, Feng X, Nguyen HTM, Zhang Y, Sebastian KR, Reichenberg JS et al. Spectral biopsy for skin cancer diagnosis: Initial clinical results. In Zeng H, Choi B, editors, Photonics in Dermatology and Plastic Surgery. SPIE. 2017. 1003704. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2251293
Moy, Austin J. ; Feng, Xu ; Nguyen, Hieu T.M. ; Zhang, Yao ; Sebastian, Katherine R. ; Reichenberg, Jason S. ; Tunnell, James W. / Spectral biopsy for skin cancer diagnosis : Initial clinical results. Photonics in Dermatology and Plastic Surgery. editor / Haishan Zeng ; Bernard Choi. SPIE, 2017. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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