T-cell prolymphocytic leukemia involving extramedullary sites

Jose R. Valbuena, Marco Herling, Joan Admirand, Anthony Padula, Dan Jones, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

T-cell prolymphocytic leukemia (T-PLL) can involve extramedullary sites, but the diagnosis is usually established by examination of blood and bone marrow. As a result, the histologic findings at extramedullary sites are poorly documented in the literature. We describe 19 extramedullary biopsy specimens from 14 patients with T-PLL. Skin (n = 10) was the most common site biopsied. T-PLL surrounded dermal blood vessels and appendages (n = 6), diffusely replaced dermis (n = 3), or formed a subcutaneous mass (n = 1). Other extramedullary sites included liver and lymph nodes (3 each) and spleen, lung, and cecum (1 each). In liver and lymph nodes, the neoplasm predominantly involved portal tracts and paracortex, respectively. Cytologically, the T-PLL cells were round (n = 16) or Sézary cell-like (n = 3). Nucleoli were observed in a subset of cells in 8 specimens and were prominent in 3 specimens. Immunostaining for T-cell leukemia-1 (TCL-1) was positive in specimens from 9 (64%) of 14 patients. We conclude that the prolymphocytoid features of T-PLL cells can be difficult to detect in routinely stained sections of extramedullary biopsy specimens. TCL-1 expression can aid in diagnosis at extramedullary sites.

Original languageEnglish (US)
Pages (from-to)456-464
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume123
Issue number3
DOIs
StatePublished - Jan 1 2005

Fingerprint

T-Cell Prolymphocytic Leukemia
T-Cell Leukemia
Lymph Nodes
Bone Marrow Examination
Biopsy
Skin
Cecum
Liver
Dermis
Blood Vessels
Spleen
Lung
Neoplasms

Keywords

  • Extramedullary sites
  • T-cell prolymphocytic leukemia
  • TCL-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

T-cell prolymphocytic leukemia involving extramedullary sites. / Valbuena, Jose R.; Herling, Marco; Admirand, Joan; Padula, Anthony; Jones, Dan; Medeiros, L. Jeffrey.

In: American Journal of Clinical Pathology, Vol. 123, No. 3, 01.01.2005, p. 456-464.

Research output: Contribution to journalArticle

Valbuena, JR, Herling, M, Admirand, J, Padula, A, Jones, D & Medeiros, LJ 2005, 'T-cell prolymphocytic leukemia involving extramedullary sites', American Journal of Clinical Pathology, vol. 123, no. 3, pp. 456-464. https://doi.org/10.1309/93P42RNG5XBG3KBE
Valbuena, Jose R. ; Herling, Marco ; Admirand, Joan ; Padula, Anthony ; Jones, Dan ; Medeiros, L. Jeffrey. / T-cell prolymphocytic leukemia involving extramedullary sites. In: American Journal of Clinical Pathology. 2005 ; Vol. 123, No. 3. pp. 456-464.
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