Targeted manipulation of apoptosis in cancer treatment

Justin A. Call, S Gail Eckhardt, D. Ross Camidge

Research output: Contribution to journalReview article

125 Citations (Scopus)

Abstract

Apoptosis is a fundamental process in the development and maintenance of multicellular organisms and its regulation is commonly disrupted in human cancers. In vitro and in vivo, effective treatment of cancer with radiotherapy or anticancer drugs (or both) is frequently associated with increased markers of apoptosis. However, clinical resistance to treatment is common in many tumours, particularly with increasing lines of therapy. Diminished ability to undergo apoptosis might cause extensive therapeutic cross-resistance in cancer cells. With increased understanding of the regulatory and effector molecules of apoptosis new drugs have been developed that might manipulate the apoptotic balance in cancer cells in favour of cell death. This Review summarises the rationale for direct manipulation of various elements of apoptosis and describes agents that are currently under investigation in early-phase clinical trials in many different cancer types.

Original languageEnglish (US)
Pages (from-to)1002-1011
Number of pages10
JournalThe Lancet Oncology
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2008

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Apoptosis
Neoplasms
Therapeutics
Pharmaceutical Preparations
Cell Death
Radiotherapy
Maintenance
Clinical Trials

ASJC Scopus subject areas

  • Oncology

Cite this

Targeted manipulation of apoptosis in cancer treatment. / Call, Justin A.; Eckhardt, S Gail; Camidge, D. Ross.

In: The Lancet Oncology, Vol. 9, No. 10, 01.10.2008, p. 1002-1011.

Research output: Contribution to journalReview article

Call, Justin A. ; Eckhardt, S Gail ; Camidge, D. Ross. / Targeted manipulation of apoptosis in cancer treatment. In: The Lancet Oncology. 2008 ; Vol. 9, No. 10. pp. 1002-1011.
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