Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models

Carolyn E. Jones, Marie Helene Monfils

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Animal models of fear conditioning provide insight into ways to reduce the intensity of a fear memory and attenuate its associated response. Two popular methods to reduce fear in animals are extinction, in which the animal is repeatedly exposed to the fear-inducing stimulus in the absence of any negative outcome, and reconsolidation blockade/update, in which the fear memory is reactivated and targeted directly using pharmacological blockade or behavioral updating mechanisms. Combining the strengths of both extinction and reconsolidation may allow researchers to persistently reduce the fear response after conditioning in animals and develop a translational model for treatment of fear and anxiety-related disorders in humans.

Original languageEnglish (US)
Title of host publicationMemory Reconsolidation
PublisherElsevier Inc.
Pages165-184
Number of pages20
ISBN (Print)9780123868923
DOIs
StatePublished - Aug 27 2013

Fingerprint

Fear
Animal Models
Psychological Extinction
Anxiety Disorders
Research Personnel
Pharmacology

Keywords

  • Animal learning
  • Extinction
  • Fear conditioning
  • Reconsolidation

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Jones, C. E., & Monfils, M. H. (2013). Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models. In Memory Reconsolidation (pp. 165-184). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386892-3.00008-1

Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models. / Jones, Carolyn E.; Monfils, Marie Helene.

Memory Reconsolidation. Elsevier Inc., 2013. p. 165-184.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jones, CE & Monfils, MH 2013, Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models. in Memory Reconsolidation. Elsevier Inc., pp. 165-184. https://doi.org/10.1016/B978-0-12-386892-3.00008-1
Jones, Carolyn E. ; Monfils, Marie Helene. / Using Reconsolidation and Extinction to Weaken Fear Memories in Animal Models. Memory Reconsolidation. Elsevier Inc., 2013. pp. 165-184
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