Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography

Dong Kyu Kim, Jared A. Weis, Thomas Yankeelov, Michael I. Miga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

There is currently no reliable method for early characterization of breast cancer response to neoadjuvant chemotherapy (NAC) [1,2]. Given that disruption of normal structural architecture occurs in cancer-bearing tissue, we hypothesize that further structural changes occur in response to NAC. Consequently, we are investigating the use of modalityindependent elastography (MIE) [3-8] as a method for monitoring mechanical integrity to predict long term outcomes in NAC. Recently, we have utilized a Demons non-rigid image registration method that allows 3D elasticity reconstruction in abnormal tissue geometries, making it particularly amenable to the evaluation of breast cancer mechanical properties. While past work has reflected relative elasticity contrast ratios [3], this study improves upon that work by utilizing a known stiffness reference material within the reconstruction framework such that a stiffness map becomes an absolute measure. To test, a polyvinyl alcohol (PVA) cryogel phantom and a silicone rubber mock mouse tumor phantom were constructed with varying mechanical stiffness. Results showed that an absolute measure of stiffness could be obtained based on a reference value. This reference technique demonstrates the ability to generate accurate measurements of absolute stiffness to characterize response to NAC. These results support that referenced MIE' has the potential to reliably differentiate absolute tumor stiffness with significant contrast from that of surrounding tissue. The use of referenced MIE to obtain absolute quantification of biomarkers is also translatable across length scales such that the characterization method is mechanics-consistent at the small animal and human application.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
ISBN (Print)9780819498311
DOIs
StatePublished - Jan 1 2014
EventMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9038
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

Fingerprint

Elasticity Imaging Techniques
Tumors
stiffness
Chemotherapy
tumors
Stiffness
mechanical properties
chemotherapy
Drug Therapy
Mechanical properties
Elasticity
Neoplasms
Cryogels
cancer
Tissue
Breast Neoplasms
Polyvinyl Alcohol
breast
Silicone Elastomers
Bearings (structural)

Keywords

  • Breast cancer
  • Elastography
  • Mechanical model
  • Mechanical properties
  • Parameter reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Kim, D. K., Weis, J. A., Yankeelov, T., & Miga, M. I. (2014). Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography. In Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging [90381F] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9038). SPIE. https://doi.org/10.1117/12.2044195

Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography. / Kim, Dong Kyu; Weis, Jared A.; Yankeelov, Thomas; Miga, Michael I.

Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE, 2014. 90381F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9038).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, DK, Weis, JA, Yankeelov, T & Miga, MI 2014, Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography. in Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging., 90381F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9038, SPIE, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/16/14. https://doi.org/10.1117/12.2044195
Kim DK, Weis JA, Yankeelov T, Miga MI. Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography. In Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2014. 90381F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2044195
Kim, Dong Kyu ; Weis, Jared A. ; Yankeelov, Thomas ; Miga, Michael I. / Utilizing a reference material for assessing absolute tumor mechanical properties in modality independent elastography. Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE, 2014. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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