Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer

Jared A. Weis, Dong K. Kim, Thomas E. Yankeelov, Michael I. Miga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Clinical observations have long suggested that cancer progression is accompanied by extracellular matrix remodeling and concomitant increases in mechanical stiffness. Due to the strong association of mechanics and tumor progression, there has been considerable interest in incorporating methodologies to diagnose cancer through the use of mechanical stiffness imaging biomarkers, resulting in commercially available US and MR elastography products. Extension of this approach towards monitoring longitudinal changes in mechanical properties along a course of cancer therapy may provide means for assessing early response to therapy; therefore a systematic study of the elasticity biomarker in characterizing cancer for therapeutic monitoring is needed. The elastography method we employ, modality independent elastography (MIE), can be described as a model-based inverse image-analysis method that reconstructs elasticity images using two acquired image volumes in a pre/post state of compression. In this work, we present preliminary data towards validation and reproducibility assessment of our elasticity biomarker in a pre-clinical model of breast cancer. The goal of this study is to determine the accuracy and reproducibility of MIE and therefore the magnitude of changes required to determine statistical differences during therapy. Our preliminary results suggest that the MIE method can accurately and robustly assess mechanical properties in a pre-clinical system and provide considerable enthusiasm for the extension of this technique towards monitoring therapy-induced changes to breast cancer tissue architecture.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
ISBN (Print)9780819498311
DOIs
StatePublished - Jan 1 2014
EventMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9038
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

Fingerprint

Elasticity Imaging Techniques
Biomarkers
breast
Elasticity
cancer
Breast Neoplasms
Monitoring
biomarkers
therapy
Stiffness
Neoplasms
Mechanical properties
elastic properties
progressions
Image analysis
Tumors
stiffness
Mechanics
Therapeutics
Association reactions

Keywords

  • Breast cancer
  • Elastography
  • Mechanical model
  • Mechanical properties
  • Parameter reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Weis, J. A., Kim, D. K., Yankeelov, T. E., & Miga, M. I. (2014). Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer. In Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging [90381I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9038). SPIE. https://doi.org/10.1117/12.2042796

Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer. / Weis, Jared A.; Kim, Dong K.; Yankeelov, Thomas E.; Miga, Michael I.

Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE, 2014. 90381I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9038).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Weis, JA, Kim, DK, Yankeelov, TE & Miga, MI 2014, Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer. in Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging., 90381I, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9038, SPIE, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/16/14. https://doi.org/10.1117/12.2042796
Weis JA, Kim DK, Yankeelov TE, Miga MI. Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer. In Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2014. 90381I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2042796
Weis, Jared A. ; Kim, Dong K. ; Yankeelov, Thomas E. ; Miga, Michael I. / Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer. Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE, 2014. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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