Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model

Katelyn M. Flint, Jared A. Weis, Thomas E. Yankeelov, Michael I. Miga

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Changes in tissue mechanical properties, measured non-invasively by elastography methods, have been shown to be an important diagnostic tool, particularly for cancer. Tissue elasticity information, tracked over the course of therapy, may be an important prognostic indicator of tumor response to treatment. While many elastography techniques exist, this work reports on the use of a novel form of elastography that uses image texture to reconstruct elastic property distributions in tissue (i.e., a modality independent elastography (MIE) method) within the context of a pre-clinical breast cancer system.1,2 The elasticity results have previously shown good correlation with independent mechanical testing.1 Furthermore, MIE has been successfully utilized to localize and characterize lesions in both phantom experiments and simulation experiments with clinical data.2,3However, the reproducibility of this method has not been characterized in previous work. The goal of this study is to evaluate voxel-level reproducibility of MIE in a pre-clinical model of breast cancer. Bland-Altman analysis of co-registered repeat MIE scans in this preliminary study showed a reproducibility index of 24.7% (scaled to a percent of maximum stiffness) at the voxel level. As opposed to many reports in the magnetic resonance elastography (MRE) literature that speak to reproducibility measures of the bulk organ, these results establish MIE reproducibility at the voxel level; i.e., the reproducibility of locally-defined mechanical property measurements throughout the tumor volume.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Robert C. Molthen
PublisherSPIE
ISBN (Electronic)9781628415070
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9417
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

Fingerprint

Elasticity Imaging Techniques
elastic properties
cancer
Tissue
breast
Tumors
Elasticity
tumors
mechanical properties
Image texture
Mechanical properties
Magnetic resonance
organs
lesions
magnetic resonance
therapy
stiffness
textures
Experiments
Stiffness

Keywords

  • Breast cancer
  • Computational modeling
  • Elastography
  • MRI
  • Mechanical properties
  • Pre-clinical
  • Reproducibility

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Flint, K. M., Weis, J. A., Yankeelov, T. E., & Miga, M. I. (2015). Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model. In B. Gimi, & R. C. Molthen (Eds.), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging [941704] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417). SPIE. https://doi.org/10.1117/12.2082230

Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model. / Flint, Katelyn M.; Weis, Jared A.; Yankeelov, Thomas E.; Miga, Michael I.

Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Robert C. Molthen. SPIE, 2015. 941704 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Flint, KM, Weis, JA, Yankeelov, TE & Miga, MI 2015, Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model. in B Gimi & RC Molthen (eds), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging., 941704, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9417, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/24/15. https://doi.org/10.1117/12.2082230
Flint KM, Weis JA, Yankeelov TE, Miga MI. Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model. In Gimi B, Molthen RC, editors, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2015. 941704. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2082230
Flint, Katelyn M. ; Weis, Jared A. ; Yankeelov, Thomas E. ; Miga, Michael I. / Voxel-level reproducibility assessment of modality independent elastography in a pre-clinical murine model. Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Robert C. Molthen. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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